ES8506272A1 - Procedimiento para preparar derivados de prolina - Google Patents

Procedimiento para preparar derivados de prolina

Info

Publication number
ES8506272A1
ES8506272A1 ES525685A ES525685A ES8506272A1 ES 8506272 A1 ES8506272 A1 ES 8506272A1 ES 525685 A ES525685 A ES 525685A ES 525685 A ES525685 A ES 525685A ES 8506272 A1 ES8506272 A1 ES 8506272A1
Authority
ES
Spain
Prior art keywords
formula
procedure
proline derivatives
alkylene
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525685A
Other languages
English (en)
Other versions
ES525685A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES8506272A1 publication Critical patent/ES8506272A1/es
Publication of ES525685A0 publication Critical patent/ES525685A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE PROLINA.COMPRENDE REACCIONAR UN COMPUESTO DE FORMULA R-A-X-A-Z CON UN COMPUESTO DE FORMULA (RCO)2CH-NR-CHR-NR-CRR-Q-R, EN PRESENCIA DE UNA BASE, SEGUIDO POR HIDROLISIS Y DESCARBOXILACION DE UNO DE LOS GRUPOS -CO PARA OBTENER DERIVADOS DE PROLINA DE FORMULA (I), DONDE R ES ARILO O UN RADICAL HETEROCICLICO Y OTROS, A ES UN ENLACE DIRECTO, ALQUILENO DE C 1 A 15 Y OTROS; X TIENE LA FORMULA (II); A ES ALQUILENO, ALQUENILENO Y OTROS; R ES H; R ES H; R ES H O ALQUILO; R ES H Y OTROS; R ES H, ARILO Y OTROS; R ES H O ALQUILO O TIENE LA FORMULA Q-R Y OTROS; Q Y Q PUEDEN SER IGUALES O DIFERENTES; Y R Y R PUEDEN SER IGUALES O DIFERENTES, REPRESENTANDO HIDROXI, AMINO, HIDROXIAMINO Y OTROS.
ES525685A 1982-01-22 1983-09-16 Procedimiento para preparar derivados de prolina Granted ES525685A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8201832 1982-01-22

Publications (2)

Publication Number Publication Date
ES8506272A1 true ES8506272A1 (es) 1985-07-01
ES525685A0 ES525685A0 (es) 1985-07-01

Family

ID=10527812

Family Applications (2)

Application Number Title Priority Date Filing Date
ES525685A Granted ES525685A0 (es) 1982-01-22 1983-09-16 Procedimiento para preparar derivados de prolina
ES525684A Expired ES8506271A1 (es) 1982-01-22 1983-09-16 Procedimiento para preparar derivados de prolina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES525684A Expired ES8506271A1 (es) 1982-01-22 1983-09-16 Procedimiento para preparar derivados de prolina

Country Status (17)

Country Link
US (1) US4528282A (es)
EP (1) EP0084941B1 (es)
JP (1) JPS58134075A (es)
AT (1) ATE25850T1 (es)
AU (1) AU563149B2 (es)
DE (1) DE3370159D1 (es)
DK (1) DK23883A (es)
ES (2) ES525685A0 (es)
FI (1) FI830186L (es)
GR (1) GR77061B (es)
HU (1) HU189637B (es)
IE (1) IE54551B1 (es)
IL (1) IL67705A0 (es)
NO (1) NO830203L (es)
NZ (1) NZ203063A (es)
PT (1) PT76130A (es)
ZA (1) ZA83273B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986000896A1 (en) * 1984-07-30 1986-02-13 Schering Corporation NOVEL PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA ADb BDPYRROLE-2-CARBOXYLATE
FR2573765B1 (fr) * 1984-11-23 1988-06-10 Solvay Procede pour la synthese de peptides
HU192914B (en) * 1985-02-11 1987-07-28 Richter Gedeon Vegyeszet Process for producing new 3-/substituted amino/-5-phenyl-2/3h/-furanone derivatives and pharmaceutically acceptable salts
ES2051702T3 (es) * 1986-04-01 1994-07-01 Wako Pure Chem Ind Ltd Derivados peptidicos y metodo para medir la actividad de sustancias fisiologicamente activas usandolos como sustratos.
AT395012B (de) * 1986-06-27 1992-08-25 Richter Gedeon Vegyeszet Verfahren zur herstellung von n-(1(s)|thoxycarbonyl-3-phenyl-propyl)-(s)-alanyl-(s)prolin und von dessen saeureadditionssalzen
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
ATE282602T1 (de) * 1996-08-16 2004-12-15 Warner Lambert Co Buttersäure matrix-metalloproteinase-inhibitoren
TR200101663T2 (tr) 1998-12-10 2001-11-21 F.Hoffmann-La Roche Ag Pro-kollajen c-proteinaz inhibitörleri
WO2004067509A1 (ja) * 2003-01-31 2004-08-12 Sanwa Kagaku Kenkyusho Co., Ltd. ジペプチジルペプチダーゼivを阻害する化合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4350633A (en) * 1980-07-01 1982-09-21 American Home Products Corporation N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
EP0048159A3 (en) * 1980-09-17 1982-05-12 University Of Miami Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
FR2492381A1 (fr) * 1980-10-21 1982-04-23 Science Union & Cie Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4296110A (en) * 1980-10-28 1981-10-20 E. I. Du Pont De Nemours And Company Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
US4390700A (en) * 1980-11-10 1983-06-28 Ciba-Geigy Corporation 1-Carboxyazaalkanoyl-tetrahydroquinoline-2-carboxylic acids
US4425355A (en) * 1981-02-17 1984-01-10 Warner-Lambert Company Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids
US4402969A (en) * 1981-03-23 1983-09-06 Merck & Co., Inc. Antihypertensive proline derivatives
US4374246A (en) * 1981-06-18 1983-02-15 Norwich Eaton Pharmaceuticals, Inc. 1-N-[(1-Carboxy-3-phenylpropyl)glycyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4370494A (en) * 1982-01-15 1983-01-25 Norwich Eaton Pharmaceuticals, Inc. Converting enzyme inhibitors

Also Published As

Publication number Publication date
ES525684A0 (es) 1985-07-01
FI830186A7 (fi) 1983-07-23
FI830186L (fi) 1983-07-23
IE54551B1 (en) 1989-11-22
IL67705A0 (en) 1983-05-15
GR77061B (es) 1984-09-05
EP0084941B1 (en) 1987-03-11
DE3370159D1 (en) 1987-04-16
AU1034183A (en) 1983-07-28
DK23883D0 (da) 1983-01-21
DK23883A (da) 1983-07-23
NZ203063A (en) 1985-12-13
ES8506271A1 (es) 1985-07-01
ATE25850T1 (de) 1987-03-15
PT76130A (en) 1983-02-01
HU189637B (en) 1986-07-28
EP0084941A1 (en) 1983-08-03
US4528282A (en) 1985-07-09
AU563149B2 (en) 1987-07-02
NO830203L (no) 1983-07-25
JPS58134075A (ja) 1983-08-10
FI830186A0 (fi) 1983-01-20
ES525685A0 (es) 1985-07-01
IE830056L (en) 1983-07-22
ZA83273B (en) 1983-10-26

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