ES8506325A1 - Un metodo de preparar 2'-desoxioxanosina - Google Patents

Un metodo de preparar 2'-desoxioxanosina

Info

Publication number
ES8506325A1
ES8506325A1 ES530508A ES530508A ES8506325A1 ES 8506325 A1 ES8506325 A1 ES 8506325A1 ES 530508 A ES530508 A ES 530508A ES 530508 A ES530508 A ES 530508A ES 8506325 A1 ES8506325 A1 ES 8506325A1
Authority
ES
Spain
Prior art keywords
formula
compound
activity against
desoxyoxanosine
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530508A
Other languages
English (en)
Other versions
ES530508A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES8506325A1 publication Critical patent/ES8506325A1/es
Publication of ES530508A0 publication Critical patent/ES530508A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE PREPARAR 2-DESOSIOXANOSINA.COMPRENDE REDUCIR CO HIDRURO DE ESTAN/O DISUSTITUIDO UN COMPUESTO DE FORMULA (II) DONDE R1 Y R2 SON GRUPOS SILILO Y PH REPRESENTA FENILO, PARA FORMAR UN COMPUESTO DE FORMULA (III) Y FINALMENTE ELIMINAR LOS GRUPOS PROTECTORES DE ESTE NUEVO COMPUESTO PARA OBTENER 2-DESOXIXANOSINA DE FORMULA (I).TIENE ACTIVIDAD ANTIBACTERIANA CONTRA BACTERIAS GRAM-NEGATIVAS Y MUESTRA ACTIVIDAD INHIBIDORA CONTRA EL DESARROLLO DE LAS CELULAS L-1210 DE LA LEUCEMIA.
ES530508A 1983-03-14 1984-03-12 Un metodo de preparar 2'-desoxioxanosina Granted ES530508A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58040802A JPS59167600A (ja) 1983-03-14 1983-03-14 ２′−デオキシオキザノシンおよびその製造法

Publications (2)

Publication Number Publication Date
ES8506325A1 true ES8506325A1 (es) 1985-07-01
ES530508A0 ES530508A0 (es) 1985-07-01

Family

ID=12590759

Family Applications (1)

Application Number Title Priority Date Filing Date
ES530508A Granted ES530508A0 (es) 1983-03-14 1984-03-12 Un metodo de preparar 2'-desoxioxanosina

Country Status (11)

Country Link
US (1) US4530998A (es)
EP (1) EP0120374B1 (es)
JP (1) JPS59167600A (es)
AT (1) ATE24519T1 (es)
CA (1) CA1209132A (es)
DE (1) DE3461806D1 (es)
DK (1) DK144284A (es)
ES (1) ES530508A0 (es)
GR (1) GR81773B (es)
HU (1) HUT35694A (es)
ZA (1) ZA841850B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5243042A (en) * 1990-08-02 1993-09-07 Hoffmann-La Roche Inc. 1-thiaguanosine and process for preparing oxanosine and 1-thiaguanosine
US6822089B1 (en) * 2000-03-29 2004-11-23 Isis Pharmaceuticals, Inc. Preparation of deoxynucleosides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3309359A (en) * 1965-10-22 1967-03-14 Hoffmann La Roche N-mono-acyl-5-fluorocytosine derivatives and process
US3562250A (en) * 1968-07-30 1971-02-09 Akad Wissenschaften Ddr 2',5'-dideoxy-5'-fluoro nucleosides and process for preparing same
US3919193A (en) * 1973-07-06 1975-11-11 Icn Pharmaceuticals 3-Deazaguanosine and derivatives thereof
JPS5788195A (en) * 1980-11-22 1982-06-01 Microbial Chem Res Found Antibiotic, oxanosine, and its preparation

Also Published As

Publication number Publication date
EP0120374B1 (en) 1986-12-30
EP0120374A1 (en) 1984-10-03
JPS59167600A (ja) 1984-09-21
JPH027598B2 (es) 1990-02-19
ES530508A0 (es) 1985-07-01
DK144284A (da) 1984-09-15
DK144284D0 (da) 1984-02-29
US4530998A (en) 1985-07-23
ATE24519T1 (de) 1987-01-15
HUT35694A (en) 1985-07-29
DE3461806D1 (en) 1987-02-05
ZA841850B (en) 1985-04-24
CA1209132A (en) 1986-08-05
GR81773B (es) 1984-12-12

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