ES8507140A1 - Procedimiento para la preparacion del citrato de la (-) vinburnina - Google Patents

Procedimiento para la preparacion del citrato de la (-) vinburnina

Info

Publication number
ES8507140A1
ES8507140A1 ES532394A ES532394A ES8507140A1 ES 8507140 A1 ES8507140 A1 ES 8507140A1 ES 532394 A ES532394 A ES 532394A ES 532394 A ES532394 A ES 532394A ES 8507140 A1 ES8507140 A1 ES 8507140A1
Authority
ES
Spain
Prior art keywords
vinburnine
citric
preparation
acid salt
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532394A
Other languages
English (en)
Other versions
ES532394A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covex SA
Original Assignee
Covex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Covex SA filed Critical Covex SA
Priority to ES532394A priority Critical patent/ES8507140A1/es
Priority to DE8484401983T priority patent/DE3476391D1/de
Priority to EP84401983A priority patent/EP0164478B1/fr
Publication of ES532394A0 publication Critical patent/ES532394A0/es
Publication of ES8507140A1 publication Critical patent/ES8507140A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE CITRATO DE (-) VINBURNINA.CONSISTE EN LA REACCION DE LA (-) VINBURNINA, DE FORMULA (I), O UNA DE SUS SALES, TAL COMO EL FOSFATO, CON EL ACIDO CITRICO, O EL CITRATO SODICO O POTASICO, EN UN MEDIO DE REACCION ALCOHOLICO O HIDROALCOHOLICO, A UNA TEMPERATURA PROXIMA A 20JC, DURANTE 5 MINUTOS; SEGUIDA DE LA SEPARACION DEL CITRATO DE LA (-) VINBURNINA, DE FORMULA (II); O BIEN DILUCION CON AGUA DE LA MEZCLA DE REACCION, PARA OBTENER UNA DISOLUCION ACUOSA QUE CONTIENE 30 MG DE PH COMPRENDIDO ENTRE 5 Y 5,5.ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS PARA MEJORAR LA CIRCULACION CEREBRAL.
ES532394A 1984-05-10 1984-05-10 Procedimiento para la preparacion del citrato de la (-) vinburnina Expired ES8507140A1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES532394A ES8507140A1 (es) 1984-05-10 1984-05-10 Procedimiento para la preparacion del citrato de la (-) vinburnina
DE8484401983T DE3476391D1 (en) 1984-05-10 1984-10-04 Citric-acid salt of (-)vinburnine and process for its preparation
EP84401983A EP0164478B1 (fr) 1984-05-10 1984-10-04 Citrate de la (-) vinburnine et son procédé de fabrication

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES532394A ES8507140A1 (es) 1984-05-10 1984-05-10 Procedimiento para la preparacion del citrato de la (-) vinburnina

Publications (2)

Publication Number Publication Date
ES532394A0 ES532394A0 (es) 1985-09-01
ES8507140A1 true ES8507140A1 (es) 1985-09-01

Family

ID=8487321

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532394A Expired ES8507140A1 (es) 1984-05-10 1984-05-10 Procedimiento para la preparacion del citrato de la (-) vinburnina

Country Status (3)

Country Link
EP (1) EP0164478B1 (es)
DE (1) DE3476391D1 (es)
ES (1) ES8507140A1 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2085630A1 (en) * 1970-04-07 1971-12-31 Le Men Georges Vincamone compsn - having vasodilator ganglioplegic and antihistamine activity
CA1117939A (en) * 1978-02-15 1982-02-09 Enrico C. Mora Derivatives of eburnamomine and related method of manufacturing

Also Published As

Publication number Publication date
ES532394A0 (es) 1985-09-01
DE3476391D1 (en) 1989-03-02
EP0164478A3 (en) 1986-03-26
EP0164478A2 (fr) 1985-12-18
EP0164478B1 (fr) 1989-01-25

Similar Documents

Publication Publication Date Title
OA09323A (en) "Imadazo /4, 5-b/ quinolinyloxyalkanoic acid amides with enhanced water solubility".
DE3567463D1 (en) 4-dimethylamino-1-hydroxybutane-1,1-diphosphonic acid, its water soluble salts, process for their preparation and its use
DE3372769D1 (en) 3-aminoquinuclidin derivatives, process for their preparation and their use as therapeutical agents
ZA857274B (en) Diarylacetylenes,their preparation and their use
DE3460577D1 (en) Sodium salt of ursodeoxycholic sulphate
OA08457A (en) Pestical composition for water treatment.
AR245176A1 (es) Compuestos azoicos hidrosolubles y procedimiento para su preparacion
EP0222098A3 (en) Water soluble triphenodioxazine compounds, process for their preparation and their use as dyestuffs
NO883582D0 (no) Katodisk elektrodeponerbart belegningspreparat.
DE3568180D1 (en) Water soluble triphenedioxazine compounds, process for their preparation and their use as dyestuffs
ZA828085B (en) Derivatives of cis,endo-2-azabicyclo-(3.3.0)-octane-3-carboxylic acid,a process for their preparation,agents containing these compounds and their use
GB2156345B (en) Alkylamine salts of 3,5-diacetylamino-2,4,6-triiodobenzoic acid as x-ray contrast agents
EP0117048A3 (en) Production of nylon 6,6 salt
DE3561743D1 (en) Water soluble pyridone-monoazo compounds, process for their preparation and their use as dyestuffs
GB2177091B (en) 5,6-epoxy-7-oxabicycloheptane substituted amino prostaglandin analogs useful in the treatment of thrombotic disease
DE3662003D1 (en) Water soluble disazo compounds, process for their preparation and their use as dyestuffs
EP0219080A3 (en) Water soluble disazo compounds, process for their preparation and their use as dyestuffs
EP0203506B1 (en) Process for the preparation of 4,4'-dinitrostilbene-disulfonic acid
ES8507140A1 (es) Procedimiento para la preparacion del citrato de la (-) vinburnina
EP0279277A3 (en) Water soluble monoazo-pyrazolone compounds, process for their preparation and their use as dyestuffs
EP0292904A3 (en) Water soluble naphtyl-azo-pyrazolon compounds, process for their preparation and their use as dyes
PH23506A (en) 1-aralkyl-substituted-1,2,4,-triazole-5-thiols as dopamine- -hydroxylase inhibitors
EP0206147A3 (en) Process for the preparation of 4,4'-dinitrodibenzyls
AR242797A1 (es) Procedimiento para la preparacion de derivados de acido 16,17-acetal substituido pregnano-21-oico.
PT83884B (en) Process for the preparation of 1 azolyl-3,3-dimethyl-tutan-2-on-and-ol derivatives

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000403