ES8507571A1 - Un procedimiento para preparar un 2-bromo-6 b, 9a-difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester - Google Patents

Un procedimiento para preparar un 2-bromo-6 b, 9a-difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester

Info

Publication number
ES8507571A1
ES8507571A1 ES538191A ES538191A ES8507571A1 ES 8507571 A1 ES8507571 A1 ES 8507571A1 ES 538191 A ES538191 A ES 538191A ES 538191 A ES538191 A ES 538191A ES 8507571 A1 ES8507571 A1 ES 8507571A1
Authority
ES
Spain
Prior art keywords
diona
diester
formula
trihidroxi
pregnadien
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538191A
Other languages
English (en)
Other versions
ES538191A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DIC Corp
Original Assignee
Dainippon Ink and Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP10536782A external-priority patent/JPS58222100A/ja
Priority claimed from JP22707682A external-priority patent/JPS58225100A/ja
Priority claimed from JP22707782A external-priority patent/JPS58225099A/ja
Application filed by Dainippon Ink and Chemicals Co Ltd filed Critical Dainippon Ink and Chemicals Co Ltd
Publication of ES538191A0 publication Critical patent/ES538191A0/es
Publication of ES8507571A1 publication Critical patent/ES8507571A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 2-BROMO-6BBB,9BAB-DIFLUORO-11BBB,17BAB,21-TRIHIDROXI-1,4-PREGNADIEN-3,20-DIONA-17,21-DIESTER, DE FORMULA (I), EN LA QUE OR1 Y OR2 PUEDEN SER UN RESTO ACILOXI O UN RESTO DE ESTER SULFURICO O FOSFORICO.CONSISTE EN LA REACCION DE REDUCCION DE UN 17BAB,21-DIHIDROXI-3,3-ETILENDIOXI-9BAB-FLUORO-5-PRGNEN-11,20-DIONA-17,21-DIESTER, DE FORMULA (II), EN LA QUE OR1 Y OR2 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I), POR TRATAMIENTO CON BOROHIDRURO DE SODIO EN UN DISOLVENTE POLAR A TEMPERATURA ENTRE 0JC Y 50JC; REACCION DEL PRODUCTO FORMADO CON UN PERACIDO, SEGUIDA DE TRATAMIENTO CON FLUORURO DE HIDROGENO, REACCION DE BROMACION, Y, FINALMENTE DESHIDROBROMACION Y DESHIDRATACION SIMULTANEAS.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIINFLAMATORIA Y ANTI-REUMATOIDE ARTRITICA.
ES538191A 1982-06-21 1984-11-30 Un procedimiento para preparar un 2-bromo-6 b, 9a-difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester Expired ES8507571A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10536782A JPS58222100A (ja) 1982-06-21 1982-06-21 ステロイド化合物の製造方法
JP22707682A JPS58225100A (ja) 1982-12-27 1982-12-27 ステロイド化合物およびその製造方法
JP22707782A JPS58225099A (ja) 1982-12-27 1982-12-27 ステロイド化合物およびその製造方法

Publications (2)

Publication Number Publication Date
ES538191A0 ES538191A0 (es) 1985-09-01
ES8507571A1 true ES8507571A1 (es) 1985-09-01

Family

ID=27310464

Family Applications (3)

Application Number Title Priority Date Filing Date
ES523430A Granted ES523430A0 (es) 1982-06-21 1983-06-20 Un procedimiento para preparar un 2-bromo-6b, 9x-difluoro-11n3, 17x, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21 diester
ES538192A Granted ES538192A0 (es) 1982-06-21 1984-11-30 Un procedimiento para preparar un 2-bromo-6b-9a - difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester
ES538191A Expired ES8507571A1 (es) 1982-06-21 1984-11-30 Un procedimiento para preparar un 2-bromo-6 b, 9a-difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES523430A Granted ES523430A0 (es) 1982-06-21 1983-06-20 Un procedimiento para preparar un 2-bromo-6b, 9x-difluoro-11n3, 17x, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21 diester
ES538192A Granted ES538192A0 (es) 1982-06-21 1984-11-30 Un procedimiento para preparar un 2-bromo-6b-9a - difluoro-11b, 17a, 21-trihidroxi-1, 4-pregnadien-3, 20-diona-17, 21-diester

Country Status (4)

Country Link
US (1) US4525303A (es)
EP (1) EP0097328B1 (es)
DE (1) DE3373189D1 (es)
ES (3) ES523430A0 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5319115A (en) * 1987-08-25 1994-06-07 Cocensys Inc. Method for making 3α-hydroxy, 3β-substituted-pregnanes
US4874855A (en) * 1987-11-04 1989-10-17 Dainippon Ink And Chemicals, Inc. Steroid compounds and process of preparing the same
FR2691968B1 (fr) * 1992-06-04 1994-07-29 Roussel Uclaf Nouveau procede de preparation d'un derive sterouide 11-ceto.
US5670676A (en) * 1995-03-16 1997-09-23 Schering Corporation Process for preparation of 9α -chloro-11β formyloxypregna-3.20-diones
US5602248A (en) * 1995-03-16 1997-02-11 Schering Corporation Process for preparation of 9α-chloro-11β-formyloxypregna-3,20-diones
HUE027463T2 (en) 2008-05-28 2016-09-28 Reveragen Biopharma Inc Non-hormonal steroid modulators of nf-kb for treatment of disease
CN103509075A (zh) * 2012-06-29 2014-01-15 中国药科大学 一种制备二氟泼尼酯的方法
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
CN108373492B (zh) * 2018-04-20 2021-12-21 江苏远大仙乐药业有限公司 一种醋酸可的松的制备方法
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2779775A (en) * 1954-09-30 1957-01-29 Merck & Co Inc Phosphate derivatives of 9alpha-fluorosteroids
US2951840A (en) * 1957-07-20 1960-09-06 Syntex Sa 6-fluoro pregnanes and intermediates therefor
US3022295A (en) * 1959-11-02 1962-02-20 Pfizer & Co C 16beta-difluorinated corticosteroids and intermediates
NL7502252A (nl) * 1974-02-27 1975-08-29 Pierrel Spa Werkwijze voor het bereiden van een geneesmid- del met anti-inflammatoire werking, gevormd ge- neesmiddel verkregen volgens deze werkwijze alsmede werkwijze voor het bereiden van in het geneesmiddel gebruikte nieuwe steroiden.
US4272446A (en) * 1974-02-27 1981-06-09 Pierrel S.P.A. Steroids and process for preparing the same
US4189440A (en) * 1974-03-08 1980-02-19 Gaetano Palladino 2-Bromo-6β-fluoro-3-keto-Δ1,4 -steroids of the pregnane series
US4221786A (en) * 1978-06-20 1980-09-09 Ciba-Geigy Corporation Novel halogenopregnadienes and process for the manufacture thereof
IT1193853B (it) * 1979-11-07 1988-08-31 Gaetano Palladino Procedimento per la preparazione di derivati di steroidi e prodotti ottenuti
US4340538A (en) * 1980-07-21 1982-07-20 The Upjohn Company Process for producing 6α-fluoro-Δ1,4 -3-keto steroids

Also Published As

Publication number Publication date
ES538191A0 (es) 1985-09-01
ES8507572A1 (es) 1985-09-01
EP0097328A2 (en) 1984-01-04
US4525303A (en) 1985-06-25
DE3373189D1 (en) 1987-10-01
ES538192A0 (es) 1985-09-01
EP0097328A3 (en) 1984-05-30
ES8504842A1 (es) 1985-04-16
ES523430A0 (es) 1985-04-16
EP0097328B1 (en) 1987-08-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203