ES8600246A1 - Un metodo de preparar derivados de 4-quinolona - Google Patents
Un metodo de preparar derivados de 4-quinolonaInfo
- Publication number
- ES8600246A1 ES8600246A1 ES530012A ES530012A ES8600246A1 ES 8600246 A1 ES8600246 A1 ES 8600246A1 ES 530012 A ES530012 A ES 530012A ES 530012 A ES530012 A ES 530012A ES 8600246 A1 ES8600246 A1 ES 8600246A1
- Authority
- ES
- Spain
- Prior art keywords
- chain length
- carbon chain
- lower alkyl
- hydrogen
- stands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HETSDWRDICBRSQ-UHFFFAOYSA-N 3h-quinolin-4-one Chemical class C1=CC=C2C(=O)CC=NC2=C1 HETSDWRDICBRSQ-UHFFFAOYSA-N 0.000 title abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 4-QUINOLONA, REPRESENTADOS POR LA FORMULA ESTRUCTURAL (I), EN LA QUE R1 Y R2 SIGNIFICAN HIDROGENO O ALQUILO INFERIOR DE 1A 8 ATOMOS DE CARBONO; Y Z SIGNIFICA FENILO CON O SIN SUSTITUYENTES, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN REDUCIR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R3 Y Z TIENEN LOS SIGNIFICADOS YA MENCIONADOS, HACIENDO BURBUJEAR PARA ELLO GAS DE ACIDO CLORHIDRICO SECO EN UNA MEZCLA DE DICHO COMPUESTO, DE TAL MODO QUE EL CITADO COMPUESTO SE SOMETE A UNA REACCION DE CIERRE DE ANILLO.DE APLICACION EN EL TRATAMIENTO DEL ASMA, DE LA FIEBRE DEL HENO, DE LA URTICARIA Y SIMILARES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57102592A JPS58219166A (ja) | 1982-06-14 | 1982-06-14 | ４−キノロン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8600246A1 true ES8600246A1 (es) | 1985-10-01 |
| ES530012A0 ES530012A0 (es) | 1985-10-01 |
Family
ID=14331501
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES523190A Granted ES523190A0 (es) | 1982-06-14 | 1983-06-13 | Un metodo de preparar derivados de 4-quinolona |
| ES530014A Expired ES8504721A1 (es) | 1982-06-14 | 1984-02-24 | Un metodo de preparar derivados de 4-quinolona |
| ES530013A Expired ES8601897A1 (es) | 1982-06-14 | 1984-02-24 | Un metodo de preparar derivados de 4-quinolona |
| ES530015A Granted ES530015A0 (es) | 1982-06-14 | 1984-02-24 | Un metodo de preparar derivados de 4-quinolona |
| ES530012A Granted ES530012A0 (es) | 1982-06-14 | 1984-02-24 | Un metodo de preparar derivados de 4-quinolona |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES523190A Granted ES523190A0 (es) | 1982-06-14 | 1983-06-13 | Un metodo de preparar derivados de 4-quinolona |
| ES530014A Expired ES8504721A1 (es) | 1982-06-14 | 1984-02-24 | Un metodo de preparar derivados de 4-quinolona |
| ES530013A Expired ES8601897A1 (es) | 1982-06-14 | 1984-02-24 | Un metodo de preparar derivados de 4-quinolona |
| ES530015A Granted ES530015A0 (es) | 1982-06-14 | 1984-02-24 | Un metodo de preparar derivados de 4-quinolona |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4711898A (es) |
| EP (1) | EP0104959B1 (es) |
| JP (1) | JPS58219166A (es) |
| KR (1) | KR900006118B1 (es) |
| CA (1) | CA1244436A (es) |
| DE (1) | DE3369316D1 (es) |
| ES (5) | ES523190A0 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4910327A (en) * | 1982-05-25 | 1990-03-20 | American Cyanamid Company | Alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid: dialkyl 3-(substituted)phenylaminobut-2-ene-dioates and methods for the preparation thereof |
| US5138088A (en) * | 1988-06-17 | 1992-08-11 | Korea Advanced Institute Of Science And Technology | Nitrobenzoyl-3-cyclopropylaminoacrylates and a process for the preparation thereof |
| KR910003634B1 (ko) * | 1988-06-17 | 1991-06-07 | 한국과학기술원 | 니트로벤조일-3-시클로프로필아미노아크릴레이트 및 그 제조방법 |
| FR2684671B1 (fr) * | 1991-11-20 | 1995-05-19 | Roussel Uclaf | Nouveaux derives de la quinoleine, leur procede de preparation et intermediaires et leur application a titre de medicaments. |
| IL100555A (en) * | 1991-02-07 | 2000-08-31 | Hoechst Marion Roussel Inc | N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them |
| FR2672597B1 (fr) * | 1991-02-07 | 1995-05-19 | Roussel Uclaf | Nouveaux derives n-substitues de la quinoleine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| FR2680511B1 (fr) * | 1991-08-20 | 1995-05-19 | Roussel Uclaf | Derives n-substitues de la quinoleine, leur procede de preparation, intermediaires obtenus, leur application comme medicaments et les compositions les renfermant. |
| ATE277017T1 (de) * | 1999-08-30 | 2004-10-15 | Maruishi Pharma | 1,2-disubstituierte 1,4-dihydro-4-oxochinolin- verbindungen |
| US20050224398A1 (en) * | 2001-10-19 | 2005-10-13 | Largent David W | Vibratory separators and sealing screens |
| US11638705B2 (en) | 2019-04-19 | 2023-05-02 | Academia Sinica | 4(1H)-quinolone derivatives and uses thereof |
| US11938127B2 (en) | 2021-09-28 | 2024-03-26 | Wayne State University | Methods and compositions relating to steroid hormone receptor-dependent proliferative disorders |
| DK4426434T3 (da) | 2021-11-02 | 2025-11-10 | Flare Therapeutics Inc | Pparg inverse agonists and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2785165A (en) * | 1953-12-22 | 1957-03-12 | Abbott Lab | Preparation of 4-aminoquinoline |
| FR1202105A (fr) * | 1956-06-14 | 1960-01-07 | Basf Ag | Procédé pour la production de quinolones-4 comportant un groupe hydoxyle sur le noyau benzénique |
| CH560193A5 (es) * | 1968-06-14 | 1975-03-27 | Ciba Geigy Ag | |
| HU167910B (es) * | 1972-11-22 | 1976-01-28 | ||
| CA1034124A (en) * | 1973-05-11 | 1978-07-04 | Ciba-Geigy Ag | Process for the manufacture of new quinolines |
| US4049715A (en) * | 1973-10-01 | 1977-09-20 | Sterling Drug Inc. | 3-[2-(4-Anisidino)phenyl]-1-phenyl-1-propiophenones and propanols |
| DE2910195A1 (de) * | 1979-03-15 | 1980-09-25 | Hoechst Ag | 2-(4-aminopiperidino)-3,4-dihydrochinoline und verfahren zu ihrer herstellung |
| ATE27451T1 (de) * | 1981-03-24 | 1987-06-15 | Ciba Geigy Ag | Acyl-chinolinonderivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische praeparate und ihre verwendung. |
-
1982
- 1982-06-14 JP JP57102592A patent/JPS58219166A/ja active Granted
-
1983
- 1983-06-10 EP EP83401199A patent/EP0104959B1/en not_active Expired
- 1983-06-10 DE DE8383401199T patent/DE3369316D1/de not_active Expired
- 1983-06-13 CA CA000430221A patent/CA1244436A/en not_active Expired
- 1983-06-13 ES ES523190A patent/ES523190A0/es active Granted
- 1983-06-14 KR KR1019830002644A patent/KR900006118B1/ko not_active Expired
-
1984
- 1984-02-24 ES ES530014A patent/ES8504721A1/es not_active Expired
- 1984-02-24 ES ES530013A patent/ES8601897A1/es not_active Expired
- 1984-02-24 ES ES530015A patent/ES530015A0/es active Granted
- 1984-02-24 ES ES530012A patent/ES530012A0/es active Granted
-
1985
- 1985-09-27 US US06/781,142 patent/US4711898A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA1244436A (en) | 1988-11-08 |
| ES530014A0 (es) | 1985-05-01 |
| JPH0310621B2 (es) | 1991-02-14 |
| KR900006118B1 (ko) | 1990-08-22 |
| JPS58219166A (ja) | 1983-12-20 |
| DE3369316D1 (en) | 1987-02-26 |
| US4711898A (en) | 1987-12-08 |
| EP0104959A1 (en) | 1984-04-04 |
| ES530013A0 (es) | 1985-11-16 |
| KR840005100A (ko) | 1984-11-03 |
| ES8504722A1 (es) | 1985-05-01 |
| ES8503333A1 (es) | 1985-02-16 |
| ES530015A0 (es) | 1985-05-01 |
| ES523190A0 (es) | 1985-02-16 |
| ES8504721A1 (es) | 1985-05-01 |
| ES8601897A1 (es) | 1985-11-16 |
| ES530012A0 (es) | 1985-10-01 |
| EP0104959B1 (en) | 1987-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |