ES8600272A1 - Un procedimiento para la preparacion de nuevos derivados de 2-sulfamoilbenzo (b) tiofeno. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de 2-sulfamoilbenzo (b) tiofeno.

Info

Publication number
ES8600272A1
ES8600272A1 ES533390A ES533390A ES8600272A1 ES 8600272 A1 ES8600272 A1 ES 8600272A1 ES 533390 A ES533390 A ES 533390A ES 533390 A ES533390 A ES 533390A ES 8600272 A1 ES8600272 A1 ES 8600272A1
Authority
ES
Spain
Prior art keywords
preparation
procedure
sulfamoilbenzo
new
thiophene derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES533390A
Other languages
English (en)
Other versions
ES533390A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES533390A0 publication Critical patent/ES533390A0/es
Publication of ES8600272A1 publication Critical patent/ES8600272A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C07F9/655354—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 2-SULFAMOILBENZO (B) TIOFENO, DE FORMULA ESTRUCTURAL (I), EN LA QUE R ES -OH O -OCOCH3.CONSISTE EN DESESTERIFICAR UN COMPUESTO DE FORMULA ESTRUCTURAL (II), EN LA QUE R10 ES ALQUILO C1-4, PARA OBTENER EL COMPUESTO EN EL QUE R ES -OH, SEGUIDO OPCIONALMENTE DE ACETILACION.DE APLICACION EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS PARA USO SISTEMICO Y OFTALMICO, ESPECIALMENTE PARA EL TRATAMIENTO DE LA PRESION INTRAOCULAR ELEVADA, ACOMPAN/ADA DE DAN/OS PATOLOGICOS, TAL COMO OCURRE EN LA ENFERMEDAD CONOCIDA COMO GLAUCOMA.
ES533390A 1983-06-20 1984-06-13 Un procedimiento para la preparacion de nuevos derivados de 2-sulfamoilbenzo (b) tiofeno. Expired ES8600272A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50609283A 1983-06-20 1983-06-20
US54719183A 1983-10-31 1983-10-31

Publications (2)

Publication Number Publication Date
ES533390A0 ES533390A0 (es) 1985-10-01
ES8600272A1 true ES8600272A1 (es) 1985-10-01

Family

ID=27055356

Family Applications (1)

Application Number Title Priority Date Filing Date
ES533390A Expired ES8600272A1 (es) 1983-06-20 1984-06-13 Un procedimiento para la preparacion de nuevos derivados de 2-sulfamoilbenzo (b) tiofeno.

Country Status (15)

Country Link
EP (1) EP0129478B1 (es)
KR (1) KR890000386B1 (es)
AU (1) AU558665B2 (es)
CA (1) CA1253151A (es)
DE (1) DE3481057D1 (es)
DK (1) DK298584A (es)
ES (1) ES8600272A1 (es)
FI (1) FI80032C (es)
GR (1) GR82372B (es)
HU (1) HUT37420A (es)
IE (1) IE57601B1 (es)
IL (1) IL72070A (es)
NO (1) NO842467L (es)
NZ (1) NZ208444A (es)
PT (1) PT78762A (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820848A (en) * 1984-12-12 1989-04-11 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents
DE3568431D1 (en) * 1984-12-12 1989-04-06 Merck & Co Inc Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them
US4731368A (en) * 1986-12-08 1988-03-15 Merck & Co., Inc. Thienopyridine sulfonamides and their ophthalmological formulation
EP0271273A3 (en) * 1986-12-08 1989-07-12 Merck & Co. Inc. Thieno-and furopyridine sulfonamides
US4808595A (en) * 1986-12-24 1989-02-28 Merck & Co., Inc. Furopyridine sulfonamides and their opthalmological compositions
CA1320487C (en) * 1987-08-03 1993-07-20 George D. Hartman Substituted thieno[2,3-.beta.]thiophene-2-sulfonamides as antiglaucoma agents
US4894390A (en) * 1987-08-03 1990-01-16 Merck & Co., Inc. Substituted thieno[2,3-b]thiophene-2-sulfonamides as antiglaucoma agents
US4751231A (en) * 1987-09-16 1988-06-14 Merck & Co., Inc. Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
US4929549A (en) * 1989-02-08 1990-05-29 Merck & Co., Inc. 5-carbamoylthieno[2,3-b]thiophene-2-sulfon-amides as topically active carbonic anhydrase inhibitors
WO1999051593A1 (en) * 1998-04-02 1999-10-14 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl-1h-imidazoles with alpha-2-adrenergic activity
US6313309B1 (en) * 1999-04-05 2001-11-06 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl—1H—imidazoles which are usefulα22-adrenoceptoR agonists/ antagonists
RU2397169C2 (ru) * 2005-03-28 2010-08-20 Тояма Кемикал Ко., Лтд. Способ получения 1-(3-(2-(1-бензотиофен-5-ил)этокси) пропил)азетидин-3-ола или его солей
ZA200708262B (en) 2005-03-28 2009-01-28 Toyama Chemical Co Ltd Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propyl)azetidin-3-ol or salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241136A1 (es) * 1981-07-13 1991-11-29 Merck E Co Inc Procedimiento para preparar esteres de 6-hidroxi-2-benzotiazolsulfonamida para tratamiento topicode presion intraocular elevada"
US4386098A (en) * 1981-11-03 1983-05-31 Merck & Co., Inc. 6-Hydroxy-2-benzothiazolesulfonamide for the topical treatment of elevated intraocular pressure
US4426388A (en) * 1982-04-02 1984-01-17 Merck & Co., Inc. 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure

Also Published As

Publication number Publication date
FI842478A7 (fi) 1984-12-21
NZ208444A (en) 1987-08-31
EP0129478B1 (en) 1990-01-17
DK298584D0 (da) 1984-06-19
KR850000428A (ko) 1985-02-27
KR890000386B1 (ko) 1989-03-16
IE57601B1 (en) 1993-01-27
IL72070A (en) 1988-11-30
DE3481057D1 (de) 1990-02-22
EP0129478A3 (en) 1987-03-25
DK298584A (da) 1984-12-21
AU558665B2 (en) 1987-02-05
GR82372B (es) 1984-12-13
IE841536L (en) 1984-12-20
IL72070A0 (en) 1984-10-31
EP0129478A2 (en) 1984-12-27
ES533390A0 (es) 1985-10-01
PT78762A (en) 1984-07-01
FI80032B (fi) 1989-12-29
FI80032C (fi) 1990-04-10
CA1253151A (en) 1989-04-25
NO842467L (no) 1985-12-21
HUT37420A (en) 1985-12-28
FI842478A0 (fi) 1984-06-19
AU2949684A (en) 1985-06-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519