ES8600640A1 - Procedimiento para la produccion de un antibiotico polieterico - Google Patents

Procedimiento para la produccion de un antibiotico polieterico

Info

Publication number
ES8600640A1
ES8600640A1 ES534644A ES534644A ES8600640A1 ES 8600640 A1 ES8600640 A1 ES 8600640A1 ES 534644 A ES534644 A ES 534644A ES 534644 A ES534644 A ES 534644A ES 8600640 A1 ES8600640 A1 ES 8600640A1
Authority
ES
Spain
Prior art keywords
polyeteric
antibiotic
procedure
ethyl acetate
separated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534644A
Other languages
English (en)
Other versions
ES534644A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8600640A1 publication Critical patent/ES8600640A1/es
Publication of ES534644A0 publication Critical patent/ES534644A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/54—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being bound directly to a nitrogen atom of two or more radicals, e.g. streptomycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/55—Streptomyces hygroscopicus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Fodder In General (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN ANTIBIOTICO POLIETERICO, DE FORMULA (I).COMPRENDE EL CULTIVO DE STREPTOMICES X-14934 EN UNA DISOLUCION ACUOSA DE CARBOHIDRATO, QUE CONTIENE UN NUTRIENTE NITROGENADO A PH DE 6,0, EN CONDICIONES AEROBICAS SUMERGIDAS, DURANTE 4 DIAS A 28JC: AL CALDO DE FERMENTACION DE AN/ADE UN VOLUMEN IGUAL DE ACETATO DE ETILO; SE AGITA Y SEPARAN LAS FASES ORGANICA Y ACUOSA Y SE EXTRAE ESTA DE NUEVO CON ACETATO DE ETILO; SE MEZCLAN LOS EXTRACTOS ORGANICOS Y A PARTIR DE LOS MISMOS SE SEPARA Y PURIFICA EL PRODUCTO SIGUIENDO METODOS CONVENCIONALES.ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS COMO AGENTE ANTIBACTERIANO Y ANTICOCCIDIAL.
ES534644A 1983-07-28 1984-07-27 Procedimiento para la produccion de un antibiotico polieterico Granted ES534644A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/518,233 US4510317A (en) 1983-07-28 1983-07-28 Antibiotic X-14934A

Publications (2)

Publication Number Publication Date
ES8600640A1 true ES8600640A1 (es) 1985-10-16
ES534644A0 ES534644A0 (es) 1985-10-16

Family

ID=24063126

Family Applications (1)

Application Number Title Priority Date Filing Date
ES534644A Granted ES534644A0 (es) 1983-07-28 1984-07-27 Procedimiento para la produccion de un antibiotico polieterico

Country Status (21)

Country Link
US (1) US4510317A (es)
EP (1) EP0133971B1 (es)
JP (1) JPS6051198A (es)
KR (1) KR910005629B1 (es)
AT (1) ATE33390T1 (es)
AU (1) AU575574B2 (es)
CA (1) CA1253097A (es)
DE (1) DE3470313D1 (es)
DK (1) DK159452C (es)
ES (1) ES534644A0 (es)
FI (1) FI76836C (es)
GR (1) GR82437B (es)
HU (1) HU193017B (es)
IE (1) IE57274B1 (es)
IL (1) IL72517A (es)
MC (1) MC1615A1 (es)
NO (1) NO158881C (es)
NZ (1) NZ209022A (es)
PH (1) PH20120A (es)
PT (1) PT78991B (es)
ZA (1) ZA845601B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707493A (en) * 1983-02-15 1987-11-17 Pfizer Inc. 19-epi-dianemycin as an anticoccidial and antibacterial agent
US4591559A (en) * 1983-07-28 1986-05-27 Hoffmann-La Roche Inc. Antibiotic X-14934A and a method for its preparation
US4625041A (en) * 1984-02-17 1986-11-25 Pfizer Inc. Acidic polycyclic ether antibiotic
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
DE3677844D1 (de) * 1985-05-28 1991-04-11 Lilly Co Eli Polyether-antibiotikum und verfahren zu seiner herstellung.
US5888788A (en) * 1994-05-18 1999-03-30 Union Nationale Des Groupements De Distillateurs D'alcool (Ungda) Use of ionophoretic polyether antibiotics for controlling bacterial growth in alcoholic fermentation
TW393413B (en) * 1996-01-19 2000-06-11 Shimano Kk Clipless bicycle pedal with large shoe-contacting area
EP2825178A4 (en) * 2012-03-16 2015-10-14 Univ Georgia Glycomimetics to inhibit pathogen-host interactions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953474A (en) * 1974-11-15 1976-04-27 Eli Lilly And Company Antibiotic A204I derivatives
GB2024806B (en) * 1978-03-16 1982-05-06 Taisho Pharmaceutical Co Ltd Onomycin derivatives
JPS5592387A (en) * 1978-12-29 1980-07-12 Taisho Pharmaceut Co Ltd Antibiotic substance tm-531
FR2463144A1 (fr) * 1979-08-13 1981-02-20 Syntex Inc Nouveaux diesters de laidlomycine, leur procede de production, compositions a usage veterinaire les contenant et leur utilisation pour accroitre le rendement d'assimilation des aliments chez un ruminant
US4431665A (en) * 1979-08-13 1984-02-14 Syntex (U.S.A.) Inc. Acylated laidlomycin derivatives
US4359583A (en) * 1980-09-16 1982-11-16 Taisho Pharmaceutical Co., Ltd. Antibiotics TM-531 B and TM-531 C
US4361649A (en) * 1981-07-20 1982-11-30 Pfizer Inc. Polycyclic ether antibiotic
GB2113671A (en) * 1982-01-19 1983-08-10 Pfizer Ltd Polycyclic ether antibiotics
GT198400008A (es) * 1983-02-15 1985-07-12 19-epi-dianemicina y procedimiento para el mismo
US4552843A (en) * 1984-02-17 1985-11-12 Pfizer Inc. Process for producing an acidic polycyclic ether antibiotic by cultivation of a novel strain of Streptomyces endus subspecies aureus

Also Published As

Publication number Publication date
EP0133971B1 (de) 1988-04-06
DK366084D0 (da) 1984-07-26
MC1615A1 (fr) 1985-07-18
DE3470313D1 (en) 1988-05-11
JPS6051198A (ja) 1985-03-22
KR850001291A (ko) 1985-03-18
FI843009L (fi) 1985-01-29
US4510317A (en) 1985-04-09
IE841949L (en) 1985-01-28
NZ209022A (en) 1987-08-31
KR910005629B1 (ko) 1991-08-01
CA1253097A (en) 1989-04-25
IL72517A (en) 1988-03-31
ZA845601B (en) 1985-03-27
HU193017B (en) 1987-08-28
HUT36178A (en) 1985-08-28
IL72517A0 (en) 1984-11-30
FI843009A0 (fi) 1984-07-27
IE57274B1 (en) 1992-07-01
AU3124684A (en) 1985-01-31
AU575574B2 (en) 1988-08-04
DK159452B (da) 1990-10-15
EP0133971A1 (de) 1985-03-13
ATE33390T1 (de) 1988-04-15
DK159452C (da) 1991-03-18
NO843054L (no) 1985-01-29
PT78991A (en) 1984-08-01
NO158881C (no) 1988-11-09
PH20120A (en) 1986-10-02
DK366084A (da) 1985-01-29
GR82437B (es) 1984-12-13
PT78991B (en) 1986-10-23
FI76836B (fi) 1988-08-31
ES534644A0 (es) 1985-10-16
NO158881B (no) 1988-08-01
FI76836C (fi) 1988-12-12

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506