ES8602006A1 - Procedimiento para preparar compuestos de 7-oxabicicloheptano y 7-oxabiciclohepteno - Google Patents
Procedimiento para preparar compuestos de 7-oxabicicloheptano y 7-oxabicicloheptenoInfo
- Publication number
- ES8602006A1 ES8602006A1 ES529305A ES529305A ES8602006A1 ES 8602006 A1 ES8602006 A1 ES 8602006A1 ES 529305 A ES529305 A ES 529305A ES 529305 A ES529305 A ES 529305A ES 8602006 A1 ES8602006 A1 ES 8602006A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- substd
- opt
- aryl
- vinylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 125000003118 aryl group Chemical group 0.000 abstract 9
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 8
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 5
- -1 vinylene, ethynylene Chemical group 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- DYWAPFDKPAHSED-UHFFFAOYSA-N 2-cycloheptyloxepane Chemical compound C1CCCCCC1C1OCCCCC1 DYWAPFDKPAHSED-UHFFFAOYSA-N 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 206010002383 Angina Pectoris Diseases 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 229940124639 Selective inhibitor Drugs 0.000 abstract 2
- 108010069102 Thromboxane-A synthase Proteins 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 2
- 210000001772 blood platelet Anatomy 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229940125692 cardiovascular agent Drugs 0.000 abstract 2
- 239000002327 cardiovascular agent Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 208000023589 ischemic disease Diseases 0.000 abstract 2
- 230000002107 myocardial effect Effects 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- 230000002537 thrombolytic effect Effects 0.000 abstract 2
- 230000000304 vasodilatating effect Effects 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- UHZXPFSCJFEFPS-UHFFFAOYSA-N 7-(cyclohepten-1-yl)-2,3,4,5-tetrahydrooxepine Chemical compound C1CCCCC=C1C1=CCCCCO1 UHZXPFSCJFEFPS-UHFFFAOYSA-N 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE 7-OXABICICLOHEPTANO Y 7-OXABICICLOHEPTENO. SE HACE REACCIONAR UN COMPUESTO DE FORMULA (I), DONDE X ES CO2R1, SIENDO R1 ALCOHILO INFERIOR. A Y B SON IGUALES O DIFERENTES Y A ES -CH-CH- O -(CH2)2- Y B PUEDE SER ADEMAS -C-C-, M-1-8 E Y ES ALCOHILO, ALQUENILO, PIRIDILO, ETC., CON UN GRUPO PROTECTOR DE SILILO DE FORMULA (II), DONDE Y, Y R3 SON ALCOHILO INFERIOR O ARILO, EN PRESENCIA DE UN DISOLVENTE INERTE PARA OBTENER UN COMPUESTO (III). POR TRATAMIENTO DE (III) CON LIOH, NEUTRALIZACION O POSTERIOR TRATAMIENTO CON UN SULFONILISOCIANATO SE OBTIENE UN COMPUESTO (IV), QUE POR REACCION CON FLUORURO DE TETRABUTILAMONIO PRODUCE COMPUESTOS DE FORMULA (I) DONDE X ES -OH O O-C-N-Z, SIENDO Z SO2-Q Y SIENDO Q ALCOHILO INFERIOR O ARILO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31951181A | 1981-11-09 | 1981-11-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES529305A0 ES529305A0 (es) | 1985-11-16 |
| ES8602006A1 true ES8602006A1 (es) | 1985-11-16 |
Family
ID=23242551
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES517189A Granted ES517189A0 (es) | 1981-11-09 | 1982-11-08 | Un procedimiento para prepar compuestos de 7-oxabicicloheptano y 7-oxabiciclohepteno. |
| ES529306A Expired ES8504808A1 (es) | 1981-11-09 | 1984-01-31 | Procedimiento para preparar compuestos de 7-oxabicicloheptano y 7-oxibiciclohepteno |
| ES529305A Expired ES8602006A1 (es) | 1981-11-09 | 1984-01-31 | Procedimiento para preparar compuestos de 7-oxabicicloheptano y 7-oxabiciclohepteno |
| ES529308A Expired ES8504809A1 (es) | 1981-11-09 | 1984-01-31 | Procedimiento para preparar compuestos de 7-oxabicicloheptano y 7-oxabiciclohepteno |
| ES529304A Expired ES8600302A1 (es) | 1981-11-09 | 1984-01-31 | Procedimiento para preparar compuestos de 7-oxabicicloheptano y 7-oxabiciclohepteno |
| ES529307A Granted ES529307A0 (es) | 1981-11-09 | 1984-01-31 | Procedimiento para preparar compuestos de 7-oxabicicloheptano |
| ES543329A Granted ES543329A0 (es) | 1981-11-09 | 1985-05-21 | Procedimiento para preparar compuestos de 7-oxabiciclohepta-no y 7-oxabiciclohepteno |
| ES544172A Expired ES8604595A1 (es) | 1981-11-09 | 1985-06-14 | Procedimiento para preparar compuestos de 7-oxabiciclohepta-no y 7-oxabicilohepteno |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES517189A Granted ES517189A0 (es) | 1981-11-09 | 1982-11-08 | Un procedimiento para prepar compuestos de 7-oxabicicloheptano y 7-oxabiciclohepteno. |
| ES529306A Expired ES8504808A1 (es) | 1981-11-09 | 1984-01-31 | Procedimiento para preparar compuestos de 7-oxabicicloheptano y 7-oxibiciclohepteno |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES529308A Expired ES8504809A1 (es) | 1981-11-09 | 1984-01-31 | Procedimiento para preparar compuestos de 7-oxabicicloheptano y 7-oxabiciclohepteno |
| ES529304A Expired ES8600302A1 (es) | 1981-11-09 | 1984-01-31 | Procedimiento para preparar compuestos de 7-oxabicicloheptano y 7-oxabiciclohepteno |
| ES529307A Granted ES529307A0 (es) | 1981-11-09 | 1984-01-31 | Procedimiento para preparar compuestos de 7-oxabicicloheptano |
| ES543329A Granted ES543329A0 (es) | 1981-11-09 | 1985-05-21 | Procedimiento para preparar compuestos de 7-oxabiciclohepta-no y 7-oxabiciclohepteno |
| ES544172A Expired ES8604595A1 (es) | 1981-11-09 | 1985-06-14 | Procedimiento para preparar compuestos de 7-oxabiciclohepta-no y 7-oxabicilohepteno |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5890588A (es) |
| ES (8) | ES517189A0 (es) |
| HU (1) | HU190817B (es) |
| ZA (1) | ZA827529B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5066480A (en) * | 1988-04-11 | 1991-11-19 | E. R. Squibb & Sons, Inc. | Method of preventing or reducing adverse reactions to protamine using a thromboxane a2 receptor antagonist |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4143054A (en) * | 1977-11-04 | 1979-03-06 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane- and 7-oxabicycloheptene compounds |
| US4187236A (en) * | 1977-11-04 | 1980-02-05 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane compounds |
-
1982
- 1982-10-14 ZA ZA827529A patent/ZA827529B/xx unknown
- 1982-11-08 ES ES517189A patent/ES517189A0/es active Granted
- 1982-11-08 HU HU358582A patent/HU190817B/hu not_active IP Right Cessation
- 1982-11-08 JP JP57196706A patent/JPS5890588A/ja active Granted
-
1984
- 1984-01-31 ES ES529306A patent/ES8504808A1/es not_active Expired
- 1984-01-31 ES ES529305A patent/ES8602006A1/es not_active Expired
- 1984-01-31 ES ES529308A patent/ES8504809A1/es not_active Expired
- 1984-01-31 ES ES529304A patent/ES8600302A1/es not_active Expired
- 1984-01-31 ES ES529307A patent/ES529307A0/es active Granted
-
1985
- 1985-05-21 ES ES543329A patent/ES543329A0/es active Granted
- 1985-06-14 ES ES544172A patent/ES8604595A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES8603856A1 (es) | 1986-01-01 |
| JPH0378398B2 (es) | 1991-12-13 |
| ES529308A0 (es) | 1985-04-16 |
| ZA827529B (en) | 1983-09-28 |
| ES8604595A1 (es) | 1986-02-01 |
| ES544172A0 (es) | 1986-02-01 |
| ES529304A0 (es) | 1985-10-01 |
| ES529305A0 (es) | 1985-11-16 |
| ES8504784A1 (es) | 1985-04-16 |
| ES8405803A1 (es) | 1984-06-16 |
| ES517189A0 (es) | 1984-06-16 |
| ES543329A0 (es) | 1986-01-01 |
| JPS5890588A (ja) | 1983-05-30 |
| ES529306A0 (es) | 1985-04-16 |
| HU190817B (en) | 1986-11-28 |
| ES529307A0 (es) | 1985-04-16 |
| ES8504809A1 (es) | 1985-04-16 |
| ES8504808A1 (es) | 1985-04-16 |
| ES8600302A1 (es) | 1985-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |