ES8602013A1 - Un procedimiento para preparar derivados de penem - Google Patents
Un procedimiento para preparar derivados de penemInfo
- Publication number
- ES8602013A1 ES8602013A1 ES539160A ES539160A ES8602013A1 ES 8602013 A1 ES8602013 A1 ES 8602013A1 ES 539160 A ES539160 A ES 539160A ES 539160 A ES539160 A ES 539160A ES 8602013 A1 ES8602013 A1 ES 8602013A1
- Authority
- ES
- Spain
- Prior art keywords
- groups
- carbon atoms
- different
- group
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 150000002961 penems Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 22
- 125000000217 alkyl group Chemical group 0.000 abstract 16
- 125000001424 substituent group Chemical group 0.000 abstract 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 10
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 8
- 125000005843 halogen group Chemical group 0.000 abstract 8
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- -1 B A compound Chemical class 0.000 abstract 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000001624 naphthyl group Chemical group 0.000 abstract 5
- 125000002217 penem group Chemical group 0.000 abstract 5
- 125000001544 thienyl group Chemical group 0.000 abstract 5
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000004414 alkyl thio group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 4
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000003368 amide group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 2
- 238000006303 photolysis reaction Methods 0.000 abstract 2
- 230000015843 photosynthesis, light reaction Effects 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000005493 quinolyl group Chemical group 0.000 abstract 2
- 125000000565 sulfonamide group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- HHXMXAQDOUCLDN-RXMQYKEDSA-N penem Chemical compound S1C=CN2C(=O)C[C@H]21 HHXMXAQDOUCLDN-RXMQYKEDSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PENEM, DE FORMULA (I), EN LA QUE R ES HIDROGENO O UN GRUPO ESTERIFICADOR; Y R1 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R9 ES ALCOHILO DE 1 A 4 ATOMOS DE CARBONO O FENILO, R10 ES CLORO O BROMO, Y R Y R1 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UNA BASE CAPAZ DE DESDOBLAR EL ENLACE TIO-CARBONILO Y LLEVAR A CABO UN CIERRE DE ANILLO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, A UNA TEMPERATURA ENTRE 0C Y 40C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA Y ACTIVIDAD INHIBIDORA E INACTIVADORA DE B-LACTAMASA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8219745 | 1982-07-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES539160A0 ES539160A0 (es) | 1985-11-01 |
| ES8602013A1 true ES8602013A1 (es) | 1985-11-01 |
Family
ID=10531540
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES523890A Granted ES523890A0 (es) | 1982-07-08 | 1983-07-06 | Un procedimiento para preparar derivados de penem. |
| ES539161A Granted ES539161A0 (es) | 1982-07-08 | 1984-12-28 | Un procedimiento para preparar de rivados de azetidinona |
| ES539160A Expired ES8602013A1 (es) | 1982-07-08 | 1984-12-28 | Un procedimiento para preparar derivados de penem |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES523890A Granted ES523890A0 (es) | 1982-07-08 | 1983-07-06 | Un procedimiento para preparar derivados de penem. |
| ES539161A Granted ES539161A0 (es) | 1982-07-08 | 1984-12-28 | Un procedimiento para preparar de rivados de azetidinona |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4738959A (es) |
| EP (1) | EP0099059B1 (es) |
| JP (1) | JPS5921693A (es) |
| KR (1) | KR900007181B1 (es) |
| AT (1) | ATE35270T1 (es) |
| AU (1) | AU567103B2 (es) |
| CA (1) | CA1227194A (es) |
| DE (1) | DE3377132D1 (es) |
| DK (1) | DK314483A (es) |
| ES (3) | ES523890A0 (es) |
| FI (1) | FI77662C (es) |
| GB (2) | GB2122619B (es) |
| GR (1) | GR78890B (es) |
| HU (3) | HU192819B (es) |
| IE (1) | IE55581B1 (es) |
| IL (1) | IL69174A0 (es) |
| MA (1) | MA19842A1 (es) |
| NO (3) | NO832487L (es) |
| NZ (1) | NZ204829A (es) |
| PH (1) | PH23148A (es) |
| PT (1) | PT76996B (es) |
| ZA (1) | ZA834955B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0091576B1 (en) * | 1982-03-26 | 1987-07-29 | Hoechst Uk Limited | 7-oxo-4-thia-1-azabicyclo(3,2,0)heptane derivatives |
| GB8416565D0 (en) * | 1984-06-29 | 1984-08-01 | Hoechst Uk Ltd | Antibacterial derivatives |
| GB2197865B (en) * | 1984-06-29 | 1989-05-17 | Hoechst Uk Ltd | Azetidinone derivatives |
| GB2197864B (en) * | 1984-06-29 | 1989-05-17 | Hoechst Uk Ltd | Antibacterial 7-oxo-4-thia-1-azabicyclo(3.2.0)-hept-2-ene derivatives |
| GB2164334B (en) * | 1984-09-10 | 1988-08-03 | Hoechst Uk Ltd | Antibacterial 7-oxo-4-thia-1-azabicyclo 3,2,0 hept-2-ene derivativess |
| JPS61236785A (ja) * | 1985-04-15 | 1986-10-22 | Sankyo Co Ltd | アゼチジノン誘導体 |
| US4868296A (en) * | 1985-10-29 | 1989-09-19 | Pfizer Inc. | 6-(1-carbamoyl-1-hydroxymethyl) penicillanic acid derivatives |
| US4797394A (en) * | 1985-10-29 | 1989-01-10 | Pfizer Inc. | 6-(1-carbamoyl-1-hydroxymethyl)penicillanic acid derivatives |
| JPS62179860A (ja) * | 1986-01-31 | 1987-08-07 | Sintokogio Ltd | 低圧鋳造装置 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4168314A (en) * | 1977-11-17 | 1979-09-18 | Merck & Co., Inc. | 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid |
| US4301074A (en) * | 1977-11-17 | 1981-11-17 | Merck & Co., Inc. | 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid |
| EP0042026B1 (de) * | 1978-02-02 | 1986-01-08 | Ciba-Geigy Ag | 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung |
| JPS5625110A (en) * | 1978-12-18 | 1981-03-10 | Bristol Myers Co | Antibacterial |
| JPS56115788A (en) * | 1980-02-19 | 1981-09-11 | Sankyo Co Ltd | Azetidinone derivative and its preparation |
| CH651037A5 (de) * | 1980-06-06 | 1985-08-30 | Sankyo Co | Penem-3-carbonsaeurederivate und verfahren zu deren herstellung. |
| GB2083462B (en) * | 1980-08-16 | 1984-05-02 | Beecham Group Ltd | 2-thiopenem derivatives |
| US4431658A (en) * | 1981-02-02 | 1984-02-14 | Schering Corporation | Aza penem compounds |
| US4347183A (en) * | 1981-02-02 | 1982-08-31 | Schering Corporation | Process for the synthesis of penems and carbapenems |
| EP0185651A1 (en) * | 1981-07-08 | 1986-06-25 | Hoechst Uk Limited | Intermediates for the production of antibacterial penem derivates |
| ES8305366A1 (es) * | 1981-07-08 | 1983-04-01 | Hoechst Uk Ltd | "procedimiento para la preparacion de derivados de penem". |
-
1983
- 1983-07-06 IL IL69174A patent/IL69174A0/xx unknown
- 1983-07-06 KR KR1019830003078A patent/KR900007181B1/ko not_active Expired
- 1983-07-06 GR GR71875A patent/GR78890B/el unknown
- 1983-07-06 AT AT83106589T patent/ATE35270T1/de not_active IP Right Cessation
- 1983-07-06 NZ NZ204829A patent/NZ204829A/en unknown
- 1983-07-06 FI FI832479A patent/FI77662C/fi not_active IP Right Cessation
- 1983-07-06 ES ES523890A patent/ES523890A0/es active Granted
- 1983-07-06 EP EP83106589A patent/EP0099059B1/en not_active Expired
- 1983-07-06 DE DE8383106589T patent/DE3377132D1/de not_active Expired
- 1983-07-06 PH PH29183A patent/PH23148A/en unknown
- 1983-07-06 US US06/511,284 patent/US4738959A/en not_active Expired - Fee Related
- 1983-07-07 HU HU832443A patent/HU192819B/hu not_active IP Right Cessation
- 1983-07-07 CA CA000432010A patent/CA1227194A/en not_active Expired
- 1983-07-07 MA MA20062A patent/MA19842A1/fr unknown
- 1983-07-07 DK DK314483A patent/DK314483A/da not_active Application Discontinuation
- 1983-07-07 NO NO832487A patent/NO832487L/no unknown
- 1983-07-07 IE IE1592/83A patent/IE55581B1/en unknown
- 1983-07-07 PT PT76996A patent/PT76996B/pt unknown
- 1983-07-07 HU HU861580A patent/HU193460B/hu unknown
- 1983-07-07 HU HU861579A patent/HU193459B/hu unknown
- 1983-07-07 JP JP58122479A patent/JPS5921693A/ja active Pending
- 1983-07-07 ZA ZA834955A patent/ZA834955B/xx unknown
- 1983-07-07 AU AU16653/83A patent/AU567103B2/en not_active Ceased
- 1983-07-08 GB GB08318513A patent/GB2122619B/en not_active Expired
-
1984
- 1984-03-21 NO NO841108A patent/NO841108L/no unknown
- 1984-07-19 NO NO842960A patent/NO842960L/no unknown
- 1984-12-28 ES ES539161A patent/ES539161A0/es active Granted
- 1984-12-28 ES ES539160A patent/ES8602013A1/es not_active Expired
-
1985
- 1985-06-17 GB GB08515248A patent/GB2160865B/en not_active Expired
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