ES8603181A1 - Procedimiento para la preparacion de derivados de ergolina sustituidos en posicion 2 - Google Patents
Procedimiento para la preparacion de derivados de ergolina sustituidos en posicion 2Info
- Publication number
- ES8603181A1 ES8603181A1 ES542072A ES542072A ES8603181A1 ES 8603181 A1 ES8603181 A1 ES 8603181A1 ES 542072 A ES542072 A ES 542072A ES 542072 A ES542072 A ES 542072A ES 8603181 A1 ES8603181 A1 ES 8603181A1
- Authority
- ES
- Spain
- Prior art keywords
- bond
- alkyl
- indicating
- new
- net2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 125000006592 (C2-C3) alkenyl group Chemical group 0.000 abstract 1
- AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical group O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001186 cumulative effect Effects 0.000 abstract 1
- 238000007336 electrophilic substitution reaction Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE ERGOLINA SUSTITUIDOS EN POSICION 2. CONSISTENTE EN: A) HACER REACCIONAR UN DERIVADO DE 2-BROMO-ERGOLINA DE FORMULA (II) CON UN LITIO-ALQUILO O UN LITIO-FENILO A TEMPERATURAS INFERIORES A 0JC, PARA OBTENER UN DERIVADO DE 2-LI-ERGOLINA DE FORMULA (III); Y B) HACER REACCIONAR A (III) CON UN REACTIVO ELECTROFILO, SELECCIONADO ENTRE DIOXIDO DE CARBONO, OXIDO DE ETILENO, METILISOCIANATO Y OTROS, A TEMPERATURAS DE C110 HASTA C50JC, EN UN DISOLVENTE INERTE; PUDIENDOSE TRANSFORMAR CON UN ACIDO FISIOLOGICAMENTE COMPATIBLE EN LA SAL CORRESPONDIENTE, EL DERIVADO DE FORMULA (I) ASI OBTENIDO. SIENDO C8FC9 Y C9FC10 UN ENLACE CC SIMPLE O UN ENLACE CFC DOBLE; R2 ALQUILO C1-3 Y R8 F METILO O LA AGRUPACION NH-CO-NET2. SE UTILIZA PORQUE SON BIOLOGICAMENTE ACTIVOS EN EL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3413658 | 1984-04-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8603181A1 true ES8603181A1 (es) | 1985-12-16 |
| ES542072A0 ES542072A0 (es) | 1985-12-16 |
Family
ID=6233289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES542072A Granted ES542072A0 (es) | 1984-04-09 | 1985-04-09 | Procedimiento para la preparacion de derivados de ergolina sustituidos en posicion 2 |
Country Status (2)
| Country | Link |
|---|---|
| CS (1) | CS248050B2 (es) |
| ES (1) | ES542072A0 (es) |
-
1985
- 1985-04-04 CS CS852527A patent/CS248050B2/cs unknown
- 1985-04-09 ES ES542072A patent/ES542072A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CS248050B2 (en) | 1987-01-15 |
| ES542072A0 (es) | 1985-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO820264L (no) | Fremgangsmaate for fremstilling av 2-penemforbindelser | |
| PT79819B (en) | Process to prepare dihydropiridazinone derivatives its salts and pharmaceutical compositions and intermediate compounds there with | |
| IL79462A0 (en) | Bactericidal formulations containing quinolonecarboxylic acids and derivatives thereof for use in veterinary medicine | |
| ES8207180A1 (es) | Procedimiento de fabricacion de derivados de tetrahidro-5,67,7a 4h-tieno (3,2-c) piridinona-2 . | |
| DE3176274D1 (en) | New cephem compounds and processes for preparation thereof | |
| ZA858418B (en) | 5-alkyl-1-phenyl-2-piperazinoalkylpyrazoline-3-one compounds and methods for the preparation thereof,intermediates for use in the preparation of said compounds and medicaments containing said compounds | |
| ES8504817A1 (es) | Un procedimiento para preparar compuestos de cefem. | |
| HUT35254A (en) | Process for preparing new cyclobutyl-alkyl-amine compounds with pharmaceutical activity and salts thereof | |
| ATE15370T1 (de) | 3-piperidinyl-indole derivate, ihre salze, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende arzneimittel. | |
| DE3279756D1 (en) | 1,5-diphenylpyrazolin-3-one compounds, process and intermediates for their preparation and medicines containing these compounds | |
| ZA812104B (en) | Derivatives of indolobenzoxazine and their salts, process for preparing them, their use as medicaments and the compositions containing them | |
| KR860004045A (ko) | 폴리사이클릭화합물의 제조방법 및 그 약학적 제제 | |
| PT75994A (en) | Process for preparing new para-substituted 3-phenoxy-1-carbonylaminoalkylamino-propanol-2-s having beta receptor blocking properties and of pharmaceutical compositions containing the same | |
| IL83154A (en) | Process for the preparation of pyrimidine derivatives and some such novel compounds | |
| ES8204729A1 (es) | Procedimiento para la preparacion de acidos de 2-(3'-tienil)propionicos 5'-sustituidos | |
| DE3361936D1 (en) | 1,1,2-triphenyl-but-1-ene derivatives, process for their preparation and their use as medicines | |
| IL98372A0 (en) | ((1-arylpyrrolidin-2yl)methyl)piperazine derivatives,their preparation and their application in therapeutics | |
| DE3060798D1 (en) | 7-methyl and 7-methyl-8-lower alkyl b/c cis or trans morphinan-6-one compounds, process for their preparation and pharmaceutical preparations containing them | |
| FR2572404B2 (fr) | Nouveaux derives de l'acide 4-oh-3-quinoleine carboxylique substitues en 2, leur procede de preparation, leur application comme medicaments et les compositions les renfermant | |
| KR920002614A (ko) | 광학적 활성 티아제토퀴놀린-3-카르복실산 화합물, 그의 제조 방법 및 그를 함유한 제약학적 조성물 | |
| FR2626279B1 (fr) | Nouveaux derives de l'indolo(3,2,1-de)(1,4)-oxazino(2,3,4-ij)(1,5) naphthyridine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant | |
| JPS57145867A (en) | Novel 6-oxabicyclo(3,2,1)octane-7-one derivative | |
| ES485333A1 (es) | Procedimiento para preparar derivados 5,6,7,8-tetrahidro-4 (3h)-quinazolinonicos y sus sales | |
| AR241434A1 (es) | Procedimiento para la preparacion de 3-(piperidinil)-1h-indazoles. | |
| JPS57145898A (en) | Novel n6, n6-dimethyladenosine derivative |