ES8603189A1 - Procedimiento para la preparacion de derivados de 2-(trial- quil-silil)-ergolina - Google Patents

Procedimiento para la preparacion de derivados de 2-(trial- quil-silil)-ergolina

Info

Publication number
ES8603189A1
ES8603189A1 ES542070A ES542070A ES8603189A1 ES 8603189 A1 ES8603189 A1 ES 8603189A1 ES 542070 A ES542070 A ES 542070A ES 542070 A ES542070 A ES 542070A ES 8603189 A1 ES8603189 A1 ES 8603189A1
Authority
ES
Spain
Prior art keywords
alkyl
bond
alpha
formula
trialkylsilyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542070A
Other languages
English (en)
Other versions
ES542070A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES8603189A1 publication Critical patent/ES8603189A1/es
Publication of ES542070A0 publication Critical patent/ES542070A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 2-(TRIALQUIL-SICIL)-ERGOLINA. CONSISTENTE EN HACER REACCIONAR UNA 2-BROMO-1-(TRIALQUIL-SICIL)-ERGOLINA DE FORMULA (II) CON UN LITIO-ALQUILO A TEMPERATURAS INFERIORES A LOS 0JC, EN PRESENCIA DE UNA AMINA TERCIARIA COMO TETRAMETILETILENDIAMINA, EN UN ESTER CICLICO, COMO TETREHIDROFURANO Y DIOXANO, COMO DISOLVENTE EN CANTIDAD 10 A 500 VECES MAYOR QUE LA EQUIMOLAR, DURANTE 2-8 HORAS PARA OBTENER DERIVADOS DE FORMULA (I) O SUS SALES OBTENIDAS POR ADICION DE ACIDO, CON UN ACIDO FISIOLOGICAMENTE COMPATIBLE. SIENDO: C8FC9 Y C9FC10 UN ENLACE CC SIMPLE O UN ENLACE CFC DOBLE, PERO NINGUN ENLACE DOBLE ACUMULADO, Y EL SUSTITUYENTE 8 ESTA EN POSICION A O B CUANDO SE TRATA DE UN ENLACE SIMPLE; R ES ALQUI/LO C1-4; R6 ES ALQUILO C1-3 Y R8 ES METILO O LA AGRUPACION NH-CO-NET2 O NH-CS-NET2. SE UTILIZAN POR SU ACTIVIDAD BIOLOGICA EN EL SISTEMA NERVIOSO CENTRAL.
ES542070A 1984-04-09 1985-04-09 Procedimiento para la preparacion de derivados de 2-(trial- quil-silil)-ergolina Granted ES542070A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843413660 DE3413660A1 (de) 1984-04-09 1984-04-09 Verfahren zur herstellung von 2-(trialkyl-silyl)-ergolinderivaten

Publications (2)

Publication Number Publication Date
ES8603189A1 true ES8603189A1 (es) 1985-12-16
ES542070A0 ES542070A0 (es) 1985-12-16

Family

ID=6233293

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542070A Granted ES542070A0 (es) 1984-04-09 1985-04-09 Procedimiento para la preparacion de derivados de 2-(trial- quil-silil)-ergolina

Country Status (3)

Country Link
CS (1) CS247100B2 (es)
DE (1) DE3413660A1 (es)
ES (1) ES542070A0 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017009406A (es) * 2015-01-20 2018-01-18 Xoc Pharmaceuticals Inc Compuestos de tipo isoergolina y usos de estos.
JP6856532B2 (ja) 2015-01-20 2021-04-07 エックスオーシー ファーマシューティカルズ インコーポレイテッドＸｏｃ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ エルゴリン化合物およびその使用
CA3064274A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3251846A (en) * 1966-05-17 G-dimethyosoergolenyl-b
US3029243A (en) * 1960-06-20 1962-04-10 Miles Lab Preparation of dihydroagroclavine from a mixture of agroclavine and elymoclavine
CH573936A5 (es) * 1971-08-05 1976-03-31 Spofa Vereinigte Pharma Werke
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity

Also Published As

Publication number Publication date
DE3413660A1 (de) 1985-10-17
CS247100B2 (en) 1986-11-13
DE3413660C2 (es) 1992-03-05
ES542070A0 (es) 1985-12-16

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