ES8604103A1 - Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo dialquilaminoalcoxi sustituido y de sus sa-les de adicion acidas y amonicas cuaternarias - Google Patents
Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo dialquilaminoalcoxi sustituido y de sus sa-les de adicion acidas y amonicas cuaternariasInfo
- Publication number
- ES8604103A1 ES8604103A1 ES543805A ES543805A ES8604103A1 ES 8604103 A1 ES8604103 A1 ES 8604103A1 ES 543805 A ES543805 A ES 543805A ES 543805 A ES543805 A ES 543805A ES 8604103 A1 ES8604103 A1 ES 8604103A1
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- alkoxy
- compounds
- carbon atoms
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000035987 intoxication Effects 0.000 abstract 1
- 231100000566 intoxication Toxicity 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS A-ETILBENZOL, CON UN GRUPO DIALQUILAMINOALCOXI SUSTITUIDO Y DE SUS SALES DE ADICION DE ACIDOS Y AMONICAS CUATERNARIAS, DE FORMULA (I), EN LA QUE R3 Y R4 REPRESENTAN ALQUILO C1-3, R1 Y R2 PUEDEN SET VARIOS TIPOS DE RADICALES; Y N VALE 2-5. COMPRENDE LA REACCION DE ALQUILACION DE UN COMPUESTO DE FORMULA (II), EN FORMA DE FENOLATO METALICO ALCALINO O AMONICO CUATERNARIO, CON UNA AMINA DE FORMULA (III), O UNA DE SUS SALES, EN LAS QUE X ES UN ATOMO DE HALOGENO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DILUYENTE INERTE, EN PRESENCIA DE UN AGENTE AGLUTINANTE DE ACIDOS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INTOXICACION ETANOLICA AGUDA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU824192A HU187208B (en) | 1982-12-28 | 1982-12-28 | Process for production of new dialcil-amino-alcoxi-benzoalcohole derivates, their acid additional and quaterner soils and medical preparates consisting of them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES543805A0 ES543805A0 (es) | 1986-01-16 |
| ES8604103A1 true ES8604103A1 (es) | 1986-01-16 |
Family
ID=10967277
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES528462A Expired ES8600205A1 (es) | 1982-12-28 | 1983-12-27 | Procedimiento de preparacion de nuevos derivados dialquilaminoalcoxibencilalcoholicos y de sus sales de adicion acidas y amonicas cuaternarias |
| ES543804A Expired ES8608476A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo dialquilaminoalcoxi sustituido y de sus sa-les de adicion acidas y amonicas cuaternarias |
| ES543803A Expired ES8604102A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo dialquilaminoalcoxi sustituido y de sus sa-les de adicion acidas y amonicas cuaternarias |
| ES543805A Expired ES8604103A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo dialquilaminoalcoxi sustituido y de sus sa-les de adicion acidas y amonicas cuaternarias |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES528462A Expired ES8600205A1 (es) | 1982-12-28 | 1983-12-27 | Procedimiento de preparacion de nuevos derivados dialquilaminoalcoxibencilalcoholicos y de sus sales de adicion acidas y amonicas cuaternarias |
| ES543804A Expired ES8608476A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo dialquilaminoalcoxi sustituido y de sus sa-les de adicion acidas y amonicas cuaternarias |
| ES543803A Expired ES8604102A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo dialquilaminoalcoxi sustituido y de sus sa-les de adicion acidas y amonicas cuaternarias |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4645779A (es) |
| EP (1) | EP0114410B1 (es) |
| JP (1) | JPS59134756A (es) |
| AT (1) | ATE19772T1 (es) |
| AU (1) | AU558261B2 (es) |
| CA (1) | CA1231970A (es) |
| DE (1) | DE3363553D1 (es) |
| DK (1) | DK163182C (es) |
| ES (4) | ES8600205A1 (es) |
| FI (1) | FI78459C (es) |
| GR (1) | GR78771B (es) |
| HU (1) | HU187208B (es) |
| IL (1) | IL70560A (es) |
| ZA (1) | ZA839615B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK368687A (da) * | 1986-11-21 | 1988-05-22 | Cheminova As | Aminoalkylerede hydroxyforbindelser og deres anvendelse som fungicider |
| CA2016738A1 (en) * | 1989-06-08 | 1990-12-08 | Philippe Guerry | Substituted aminoalkylbenzene derivatives |
| US5214046A (en) * | 1989-07-27 | 1993-05-25 | Hoffmann-La Roche Inc. | Substituted aminoalkoxybenzene anti-fungicidal compositions and use |
| CA2020888A1 (en) * | 1989-07-27 | 1991-01-28 | Philippe Guerry | Substituted aminoalkoxybenzene derivatives |
| GB9303210D0 (en) * | 1993-02-17 | 1993-03-31 | Univ Manitoba | Cancer treatment |
| CA2190699A1 (en) * | 1995-12-08 | 1997-06-09 | Johannes Aebi | Tertiary amines |
| WO2002076925A2 (en) * | 2001-03-23 | 2002-10-03 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
| US7314937B2 (en) | 2002-03-21 | 2008-01-01 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses |
| US7858825B2 (en) * | 2007-02-15 | 2010-12-28 | Colorado State University Research Foundation | Acid and base stable diphenylmethanol derivatives and methods of use |
| PL2892540T3 (pl) * | 2012-09-06 | 2018-12-31 | Mcpharma Biotech Inc. | Leczenie biegunki i biegunki po odsadzeniu przy pomocy opornej skrobi ziemniaczanej |
| AU2013359919A1 (en) | 2012-12-11 | 2015-07-02 | Nano Safe Coatings Incorporated (A Florida Corporation 3 P14000024914) | UV cured benzophenone terminated quaternary ammonium antimicrobials for surfaces |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3075014A (en) * | 1960-06-14 | 1963-01-22 | Richardson Merrell Inc | Basic substituted alkoxy diphenylalkanols, diphenylalkenes and diphenylalkanes |
| US3494961A (en) * | 1965-03-12 | 1970-02-10 | Hoffmann La Roche | 1,4-bis-(p-(dialkylaminoalkoxy)aryl)-1,4-bis-(aryl)-2-b-1,4-diols |
| US4094908A (en) * | 1973-08-15 | 1978-06-13 | Richter Gedeon Vegyeszeti Gyar Rt. | Alpha-substituted benzhydrol derivatives |
| HU168432B (es) * | 1973-08-15 | 1976-04-28 |
-
1982
- 1982-12-28 HU HU824192A patent/HU187208B/hu not_active IP Right Cessation
-
1983
- 1983-12-23 CA CA000444257A patent/CA1231970A/en not_active Expired
- 1983-12-23 AU AU22915/83A patent/AU558261B2/en not_active Ceased
- 1983-12-27 US US06/565,913 patent/US4645779A/en not_active Expired - Fee Related
- 1983-12-27 ES ES528462A patent/ES8600205A1/es not_active Expired
- 1983-12-27 JP JP58244952A patent/JPS59134756A/ja active Granted
- 1983-12-27 FI FI834800A patent/FI78459C/fi not_active IP Right Cessation
- 1983-12-27 ZA ZA839615A patent/ZA839615B/xx unknown
- 1983-12-27 IL IL70560A patent/IL70560A/xx unknown
- 1983-12-27 DK DK601683A patent/DK163182C/da active
- 1983-12-28 GR GR73369A patent/GR78771B/el unknown
- 1983-12-28 AT AT83113177T patent/ATE19772T1/de not_active IP Right Cessation
- 1983-12-28 DE DE8383113177T patent/DE3363553D1/de not_active Expired
- 1983-12-28 EP EP83113177A patent/EP0114410B1/de not_active Expired
-
1985
- 1985-06-01 ES ES543804A patent/ES8608476A1/es not_active Expired
- 1985-06-01 ES ES543803A patent/ES8604102A1/es not_active Expired
- 1985-06-01 ES ES543805A patent/ES8604103A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US4645779A (en) | 1987-02-24 |
| ES8604102A1 (es) | 1986-01-16 |
| FI834800L (fi) | 1984-06-29 |
| JPS6340780B2 (es) | 1988-08-12 |
| ES8608476A1 (es) | 1986-07-16 |
| DK163182C (da) | 1992-06-22 |
| GR78771B (es) | 1984-10-02 |
| IL70560A0 (en) | 1984-03-30 |
| EP0114410A1 (de) | 1984-08-01 |
| CA1231970A (en) | 1988-01-26 |
| DK601683A (da) | 1984-06-29 |
| DK601683D0 (da) | 1983-12-27 |
| HU187208B (en) | 1985-11-28 |
| ES543803A0 (es) | 1986-01-16 |
| FI834800A0 (fi) | 1983-12-27 |
| FI78459C (fi) | 1989-08-10 |
| FI78459B (fi) | 1989-04-28 |
| ES528462A0 (es) | 1985-10-01 |
| ES8600205A1 (es) | 1985-10-01 |
| ES543805A0 (es) | 1986-01-16 |
| JPS59134756A (ja) | 1984-08-02 |
| AU2291583A (en) | 1984-07-05 |
| ES543804A0 (es) | 1986-07-16 |
| DE3363553D1 (en) | 1986-06-19 |
| DK163182B (da) | 1992-02-03 |
| EP0114410B1 (de) | 1986-05-14 |
| AU558261B2 (en) | 1987-01-22 |
| IL70560A (en) | 1986-12-31 |
| ZA839615B (en) | 1984-08-29 |
| ATE19772T1 (de) | 1986-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |