ES8604734A1 - Un procedimiento para la preparacion de derivados de -lactama. - Google Patents
Un procedimiento para la preparacion de derivados de -lactama.Info
- Publication number
- ES8604734A1 ES8604734A1 ES520214A ES520214A ES8604734A1 ES 8604734 A1 ES8604734 A1 ES 8604734A1 ES 520214 A ES520214 A ES 520214A ES 520214 A ES520214 A ES 520214A ES 8604734 A1 ES8604734 A1 ES 8604734A1
- Authority
- ES
- Spain
- Prior art keywords
- lactams
- compsns
- cpds
- esp
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000003952 β-lactams Chemical class 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 206010057190 Respiratory tract infections Diseases 0.000 abstract 1
- 125000000656 azaniumyl group Chemical group [H][N+]([H])([H])[*] 0.000 abstract 1
- 239000003781 beta lactamase inhibitor Substances 0.000 abstract 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000004396 mastitis Diseases 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 208000019206 urinary tract infection Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE B-LACTAMA, DE FORMULA GENERAL (I), EN LA QUE R1 ES CO2-, CO2H O CO2R5, SIENDO R5 UN GRUPO TAL QUE EL AGRUPAMIENTO CO2R5 SEA UN ESTER HIDROLIZABLE IN VIVO FARMACEUTICAMENTE ACEPTABLE; Y R2 Y R3 REPRESENTAN INDEPENDIENTEMENTE UNGRUPO HIDROCARBONADO C1-12 OPCIONALMENTE SUSTITUIDO CON UN SUSTITUYENTE FUNCIONAL. CONSISTE EN LA HIDROGENACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R6 ES CO2-, CO2H O CO2RX, SIENDO RX UN GRUPO BLOQUEANTE DEL CARBOXI; Z ES UN ION CARGADO NEGATIVAMENTE; N ES 0 O 1 DE MODO QUE EL COMPUESTO DE FORMULA (II) SEA ELECTRONICAMENTE NEUTRO; Y R7 ES UN GRUPO R4 HIDROGENIZABLE. DE APLICACION EN EL TRATAMIENTO DE INFECCIONES EN ANIMALES, ESPECIALMENTE MAMIFEROS INCLUYENDO AL HOMBRE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8107504 | 1981-03-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8604734A1 true ES8604734A1 (es) | 1984-04-01 |
| ES520214A0 ES520214A0 (es) | 1984-04-01 |
Family
ID=10520283
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES510266A Expired ES8403452A1 (es) | 1981-03-10 | 1982-03-09 | Un procedimiento para la preparacion de b-lactama. |
| ES520214A Granted ES520214A0 (es) | 1981-03-10 | 1983-03-01 | Un procedimiento para la preparacion de derivados de -lactama. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES510266A Expired ES8403452A1 (es) | 1981-03-10 | 1982-03-09 | Un procedimiento para la preparacion de b-lactama. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0062407A1 (es) |
| JP (1) | JPS57167988A (es) |
| AU (1) | AU8121982A (es) |
| ES (2) | ES8403452A1 (es) |
| ZA (1) | ZA821511B (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU503489B2 (en) * | 1975-10-13 | 1979-09-06 | Beecham Group Limited | Substituted aminodeoxy clavulanic acid |
| NL7612937A (nl) * | 1975-11-21 | 1977-05-24 | Merck & Co Inc | Thienamycinederivaten en farmaceutische prepa- raten alsmede werkwijze voor het bereiden daarvan. |
| GB1604822A (en) * | 1977-04-22 | 1981-12-16 | Beecham Group Ltd | N-monosubstituted-9-amino-9-deoxyclavulanic acid derivative |
-
1982
- 1982-03-02 EP EP82301060A patent/EP0062407A1/en not_active Ceased
- 1982-03-08 ZA ZA821511A patent/ZA821511B/xx unknown
- 1982-03-09 AU AU81219/82A patent/AU8121982A/en not_active Abandoned
- 1982-03-09 ES ES510266A patent/ES8403452A1/es not_active Expired
- 1982-03-10 JP JP57037892A patent/JPS57167988A/ja active Pending
-
1983
- 1983-03-01 ES ES520214A patent/ES520214A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0062407A1 (en) | 1982-10-13 |
| ZA821511B (en) | 1983-01-26 |
| JPS57167988A (en) | 1982-10-16 |
| AU8121982A (en) | 1982-09-23 |
| ES520214A0 (es) | 1984-04-01 |
| ES510266A0 (es) | 1983-08-01 |
| ES8403452A1 (es) | 1983-08-01 |
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