ES8604939A1 - Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol - Google Patents

Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol

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Publication number
ES8604939A1
ES8604939A1 ES549021A ES549021A ES8604939A1 ES 8604939 A1 ES8604939 A1 ES 8604939A1 ES 549021 A ES549021 A ES 549021A ES 549021 A ES549021 A ES 549021A ES 8604939 A1 ES8604939 A1 ES 8604939A1
Authority
ES
Spain
Prior art keywords
triazol
propan
bis
difluorophenil
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549021A
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English (en)
Other versions
ES549021A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inke SA
Original Assignee
Inke SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inke SA filed Critical Inke SA
Priority to ES549021A priority Critical patent/ES8604939A1/es
Publication of ES549021A0 publication Critical patent/ES549021A0/es
Publication of ES8604939A1 publication Critical patent/ES8604939A1/es
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL 2-(2,4-DIFLUOROFENIL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-IL)-PROPAN-2-OL. COMPRENDE: A) HACER REACCIONAR AL ESTER METILICO DEL ACIDO 2,4-DIFLUOROBENZOICO DE FORMULA (II) CON UN COMPUESTO ORGANOMETALICO DE FORMULA (III), EN UNA RELACION DE (III/II) (2:1), EN TETRAHIDROFURANO, DIOXANO O HEXANO, Y A UNA TEMPERATURA ENTRE 0JC Y LA DE REFLUJO DEL DISOLVENTE, PARA OBTENER LA 2-(2,4-DIFLUOROFENIL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-IL)-PROPAN-2-OL DE FORMULA (I); Y B) RECRISTALIZAR A (I) EN ISOPROPANOL O ACETATO DE ETILO, PARA OBTENERLO QUIMICAMENTE PURO. SIENDO: X, CL, BR O YODO. SE UTILIZAN COMO ANTIFUNGICOS.
ES549021A 1985-11-19 1985-11-19 Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol Expired ES8604939A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES549021A ES8604939A1 (es) 1985-11-19 1985-11-19 Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES549021A ES8604939A1 (es) 1985-11-19 1985-11-19 Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol

Publications (2)

Publication Number Publication Date
ES549021A0 ES549021A0 (es) 1986-03-01
ES8604939A1 true ES8604939A1 (es) 1986-03-01

Family

ID=8490207

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549021A Expired ES8604939A1 (es) 1985-11-19 1985-11-19 Procedimiento para la obtencion del 2-(2,4-difluorofenil)- 1,3-bis(1h-1,2,4-triazol-1-il)-propan-2-ol

Country Status (1)

Country Link
ES (1) ES8604939A1 (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2049663A1 (es) * 1992-10-13 1994-04-16 Genesis Para La Investigacion Procedimiento de obtencion de fluconazol.
AT400145B (de) * 1990-06-08 1995-10-25 Ind Chimica Srl Verfahren zur herstellung von triazolyl-isopropanolen
BG66152B1 (bg) * 2001-03-23 2011-08-31 Richter Gedeon Vegyeszeti Gyar Rt. Метод за получаване на флуконазол и неговите кристални модификации
CN102344419A (zh) * 2011-09-16 2012-02-08 浙江金伯士药业有限公司 广谱抗真菌药氟康唑的制备方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400145B (de) * 1990-06-08 1995-10-25 Ind Chimica Srl Verfahren zur herstellung von triazolyl-isopropanolen
ES2049663A1 (es) * 1992-10-13 1994-04-16 Genesis Para La Investigacion Procedimiento de obtencion de fluconazol.
BG66152B1 (bg) * 2001-03-23 2011-08-31 Richter Gedeon Vegyeszeti Gyar Rt. Метод за получаване на флуконазол и неговите кристални модификации
CN102344419A (zh) * 2011-09-16 2012-02-08 浙江金伯士药业有限公司 广谱抗真菌药氟康唑的制备方法

Also Published As

Publication number Publication date
ES549021A0 (es) 1986-03-01

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FD1A Patent lapsed

Effective date: 20051207