ES8604969A2 - Mejoras en el objeto de la patente de invencion n 529.608 que se refiere a procedimiento de obtencion de nuevos derivados del 1h-imidazol - Google Patents
Mejoras en el objeto de la patente de invencion n 529.608 que se refiere a procedimiento de obtencion de nuevos derivados del 1h-imidazolInfo
- Publication number
- ES8604969A2 ES8604969A2 ES535656A ES535656A ES8604969A2 ES 8604969 A2 ES8604969 A2 ES 8604969A2 ES 535656 A ES535656 A ES 535656A ES 535656 A ES535656 A ES 535656A ES 8604969 A2 ES8604969 A2 ES 8604969A2
- Authority
- ES
- Spain
- Prior art keywords
- imidazole derivatives
- relating
- matter
- subject
- benzo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical group C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 229910052801 chlorine Chemical group 0.000 abstract 2
- 239000000460 chlorine Chemical group 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910000104 sodium hydride Inorganic materials 0.000 abstract 1
- 239000012312 sodium hydride Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
MEJORAS EN EL OBJETO DE LA PATENTE DE INVENCION NUM. 529.608 QUE SE REFIERE A PROCEDIMIENTO DE OBTENCION DE NUEVOS DERIVADOS DEL 1H-IMIDAZOL. CONSISTE EN: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN UN DISOLVENTE APROTICO, COMO HEXAMETILFOSFOROTRIAMINA, EN PRESENCIA DE UNA BASE MINERAL, COMO HIDRURO SODICO, A UNA TEMPERATURA DE 0 A 100JC, DURANTE 1 A 24 HORAS, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES NO TOXICAS FARMACEUTICAMENTE ACEPTABLES, PREFERENTEMENTE MONONITRATOS; Y B) PURIFICAR POR CRISTALIZACION; EXTRACCION; LAVADO CON AGUA, SECADO Y CROMATROGRAFIA DE COLU
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES535656A ES8604969A2 (es) | 1984-08-06 | 1984-08-06 | Mejoras en el objeto de la patente de invencion n 529.608 que se refiere a procedimiento de obtencion de nuevos derivados del 1h-imidazol |
| CA000472063A CA1250586A (en) | 1984-02-02 | 1985-01-14 | 1h-imidazole derivatives and process for their production |
| EP85101086A EP0151477B1 (en) | 1984-02-02 | 1985-02-01 | 1h-imidazole derivatives, a process for preparing them and pharmaceutical compositions containing them |
| DE8585101086T DE3579602D1 (de) | 1984-02-02 | 1985-02-01 | 1h-imidazol-derivate, ein verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. |
| PH31802A PH21405A (en) | 1984-02-02 | 1985-02-01 | Ih-imidazole derivatives and process for their preparation |
| US07/649,764 US5135943A (en) | 1984-02-02 | 1991-02-01 | 1H-imidazole derivative compounds and pharmaceutical compositions containing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES535656A ES8604969A2 (es) | 1984-08-06 | 1984-08-06 | Mejoras en el objeto de la patente de invencion n 529.608 que se refiere a procedimiento de obtencion de nuevos derivados del 1h-imidazol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES535656A0 ES535656A0 (es) | 1986-02-16 |
| ES8604969A2 true ES8604969A2 (es) | 1986-02-16 |
Family
ID=8487840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES535656A Expired ES8604969A2 (es) | 1984-02-02 | 1984-08-06 | Mejoras en el objeto de la patente de invencion n 529.608 que se refiere a procedimiento de obtencion de nuevos derivados del 1h-imidazol |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES8604969A2 (es) |
-
1984
- 1984-08-06 ES ES535656A patent/ES8604969A2/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES535656A0 (es) | 1986-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20050214 |