ES8605524A1 - Procedimiento para preparar tieno- y furo-(2,3-c)-pirroles - Google Patents
Procedimiento para preparar tieno- y furo-(2,3-c)-pirrolesInfo
- Publication number
- ES8605524A1 ES8605524A1 ES547789A ES547789A ES8605524A1 ES 8605524 A1 ES8605524 A1 ES 8605524A1 ES 547789 A ES547789 A ES 547789A ES 547789 A ES547789 A ES 547789A ES 8605524 A1 ES8605524 A1 ES 8605524A1
- Authority
- ES
- Spain
- Prior art keywords
- denotes
- carbon atoms
- denote
- furo
- thieno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 150000003233 pyrroles Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- WUACDRFRFTWMHE-UHFFFAOYSA-N 3,4-diaminocyclobut-3-ene-1,2-dione Chemical compound NC1=C(N)C(=O)C1=O WUACDRFRFTWMHE-UHFFFAOYSA-N 0.000 abstract 1
- BCWUZUYZBGMZFZ-UHFFFAOYSA-N 5h-furo[2,3-c]pyrrole Chemical compound N1C=C2OC=CC2=C1 BCWUZUYZBGMZFZ-UHFFFAOYSA-N 0.000 abstract 1
- 102000003710 Histamine H2 Receptors Human genes 0.000 abstract 1
- 108090000050 Histamine H2 Receptors Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- JOXZECKPVZVTDS-UHFFFAOYSA-N sulfamoylmethanimidamide Chemical group NC(=N)S(N)(=O)=O JOXZECKPVZVTDS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE TIENO- Y FURO-2,3-C-PIRROLES, DE FORMULA (I), EN LA QUE X1 Y X2 REPRESENTAN OXIGENO O AZUFRE; R2 REPRESENTA HIDROGENO O ALQUILO; R1 Y U PUEDEN SER VARIOS TIPOS DE RADICALES; Y M VALE 2 O 3. COMPRENDE LA REACCION DE UNA AMINA DE FORMULA (II), CON UN COMPUESTO DE UNA DE LAS FORMULAS (III), (IV), O (V); SEGUIDA DEL TRATAMIENTO DEL COMPUESTO ASI FORMADO CON UNA AMINA DE FORMULA R3NH2 O UNA HIDRAZINA DE FORMULA R4NHNH2, FORMULAS EN LAS QUE V ES NITROGENO O CH, W ES NO2 O CN, R3 PUEDE SER VARIOS RADICALES, R4 ES ALQUILO C1-3, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANTISECRETORAS Y ANTIULCEROSAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8415658A FR2571723B1 (fr) | 1984-10-12 | 1984-10-12 | Derives de thieno et furo-(2,3-c) pyrroles, procedes de preparation et medicaments les contenant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES547789A0 ES547789A0 (es) | 1986-03-16 |
| ES8605524A1 true ES8605524A1 (es) | 1986-03-16 |
Family
ID=9308598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES547789A Expired ES8605524A1 (es) | 1984-10-12 | 1985-10-11 | Procedimiento para preparar tieno- y furo-(2,3-c)-pirroles |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0180500A1 (es) |
| JP (1) | JPS6197286A (es) |
| AU (1) | AU593776B2 (es) |
| CA (1) | CA1250847A (es) |
| CS (1) | CS265211B2 (es) |
| DD (1) | DD237662A5 (es) |
| DK (1) | DK465685A (es) |
| ES (1) | ES8605524A1 (es) |
| FR (1) | FR2571723B1 (es) |
| HU (1) | HU193827B (es) |
| IL (1) | IL76619A (es) |
| IN (1) | IN169684B (es) |
| MA (1) | MA20543A1 (es) |
| NO (1) | NO161917C (es) |
| OA (1) | OA08119A (es) |
| PT (1) | PT81282B (es) |
| SU (1) | SU1329621A3 (es) |
| YU (1) | YU162485A (es) |
| ZA (1) | ZA857809B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60255756A (ja) * | 1984-06-01 | 1985-12-17 | Ikeda Mohandou:Kk | アミノアルキルフエノキシ誘導体 |
| RU2150470C1 (ru) * | 1994-04-19 | 2000-06-10 | Такеда Кемикал Индастриз Лтд. | Бициклические производные тиофена, способ их получения и композиция на их основе |
| FR2733750B1 (fr) * | 1995-05-03 | 1997-06-13 | Synthelabo | Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique |
| EP1543011B1 (en) * | 2002-09-06 | 2006-05-03 | Janssen Pharmaceutica N.V. | Thienopyrrolyl and furanopyrrolyl compounds and their use as histamine h4 receptor ligands |
| CN101186612B (zh) * | 2006-11-15 | 2012-10-03 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用 |
| US20230349922A1 (en) | 2020-08-11 | 2023-11-02 | Université De Strasbourg | H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1565966A (en) * | 1976-08-04 | 1980-04-23 | Allen & Hanburys Ltd | Aminoalkyl furan derivatives |
| GB1601459A (en) * | 1977-05-17 | 1981-10-28 | Allen & Hanburys Ltd | Aminoalkyl thiophene derivatives |
| US4390701A (en) * | 1981-05-18 | 1983-06-28 | Bristol-Myers Company | 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione |
| US4520025A (en) * | 1982-07-21 | 1985-05-28 | William H. Rorer, Inc. | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
-
1984
- 1984-10-12 FR FR8415658A patent/FR2571723B1/fr not_active Expired
-
1985
- 1985-10-04 CS CS857144A patent/CS265211B2/cs unknown
- 1985-10-04 EP EP85401941A patent/EP0180500A1/fr not_active Withdrawn
- 1985-10-08 MA MA20767A patent/MA20543A1/fr unknown
- 1985-10-09 ZA ZA857809A patent/ZA857809B/xx unknown
- 1985-10-09 IL IL76619A patent/IL76619A/xx unknown
- 1985-10-10 DD DD85281615A patent/DD237662A5/de not_active IP Right Cessation
- 1985-10-10 PT PT81282A patent/PT81282B/pt not_active IP Right Cessation
- 1985-10-11 OA OA58701A patent/OA08119A/xx unknown
- 1985-10-11 JP JP60225005A patent/JPS6197286A/ja active Pending
- 1985-10-11 AU AU48528/85A patent/AU593776B2/en not_active Ceased
- 1985-10-11 YU YU01624/85A patent/YU162485A/xx unknown
- 1985-10-11 NO NO854051A patent/NO161917C/no unknown
- 1985-10-11 SU SU853963352A patent/SU1329621A3/ru active
- 1985-10-11 DK DK465685A patent/DK465685A/da not_active Application Discontinuation
- 1985-10-11 CA CA000492893A patent/CA1250847A/fr not_active Expired
- 1985-10-11 ES ES547789A patent/ES8605524A1/es not_active Expired
- 1985-10-11 HU HU853957A patent/HU193827B/hu not_active IP Right Cessation
- 1985-10-22 IN IN881/DEL/85A patent/IN169684B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SU1329621A3 (ru) | 1987-08-07 |
| ES547789A0 (es) | 1986-03-16 |
| CS265211B2 (en) | 1989-10-13 |
| HU193827B (en) | 1987-12-28 |
| FR2571723B1 (fr) | 1988-08-26 |
| ZA857809B (en) | 1986-05-28 |
| DD237662A5 (de) | 1986-07-23 |
| YU162485A (en) | 1987-12-31 |
| AU593776B2 (en) | 1990-02-22 |
| OA08119A (fr) | 1987-03-31 |
| DK465685D0 (da) | 1985-10-11 |
| PT81282A (fr) | 1985-11-01 |
| FR2571723A1 (fr) | 1986-04-18 |
| DK465685A (da) | 1986-04-13 |
| IL76619A (en) | 1990-07-12 |
| IN169684B (es) | 1991-12-07 |
| HUT40133A (en) | 1986-11-28 |
| NO854051L (no) | 1986-04-14 |
| CA1250847A (fr) | 1989-03-07 |
| EP0180500A1 (fr) | 1986-05-07 |
| JPS6197286A (ja) | 1986-05-15 |
| AU4852885A (en) | 1986-04-17 |
| IL76619A0 (en) | 1986-02-28 |
| PT81282B (pt) | 1988-02-17 |
| NO161917C (no) | 1989-10-11 |
| CS714485A2 (en) | 1988-08-16 |
| NO161917B (no) | 1989-07-03 |
| MA20543A1 (fr) | 1986-07-01 |
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