ES8606407A1 - Un procedimiento para preparar conjugados de galactosil-insulina - Google Patents

Un procedimiento para preparar conjugados de galactosil-insulina

Info

Publication number
ES8606407A1
ES8606407A1 ES530759A ES530759A ES8606407A1 ES 8606407 A1 ES8606407 A1 ES 8606407A1 ES 530759 A ES530759 A ES 530759A ES 530759 A ES530759 A ES 530759A ES 8606407 A1 ES8606407 A1 ES 8606407A1
Authority
ES
Spain
Prior art keywords
insulin
conjugates
galactosyl
conjugates useful
insulin conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530759A
Other languages
English (en)
Other versions
ES530759A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of ES530759A0 publication Critical patent/ES530759A0/es
Publication of ES8606407A1 publication Critical patent/ES8606407A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR CONJUGADOS DE GALACTOSIL-INSULINA. COMPRENDE: A) DISOLVER ACIDO LACTOBIONICO O ACIDO MELIBIONICO Y N,NK-DICICLOHEXILCARBODIIMIDA EN UN DISOLVENTE APROTICO COMO PIRIDINA, A UNA TEMPERATURA DE 0JC DURANTE 0,5 HORAS; B) AÑADIR N-HIDROXISUCCINIMIDA AL DISOLVENTE APROTICO; C) DESPUES DE LA OPERACION (B), AGITAR EL DISOLVENTE A 3JC DURANTE 20 HORAS PARA FORMAR EL ESTER LACTOBIONATO O MELIOBIONATO DE N-HIDROXISUCCINIMIDA; D) DISOLVER EL ESTER LACTOBIONATO O MELIBIONATO DE N-HIDROXISUCCINIMIDA EN AGUA PARA FORMAR UNA SOLUCION ACUOSA DEL MISMO; E) AÑADIR LA SOLUCION ACUOSA GOTA A GOTA DURANTE UN PERIODO DE 30 MINUTOS A UNA SOLUCION SALINA QUE CONTIENE INSULINA MANTENIDA A UN PH DE 7 U 8,5, Y A TEMPERTURA AMBIENTE; Y F) SEPARAR LOS CONJUGADOS DE LACTOBIONIL-INSULINA O MELIBIONOL-INSULINA DE LA SOLUCION SALINA.
ES530759A 1983-03-21 1984-03-20 Un procedimiento para preparar conjugados de galactosil-insulina Expired ES8606407A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47755583A 1983-03-21 1983-03-21

Publications (2)

Publication Number Publication Date
ES530759A0 ES530759A0 (es) 1986-04-01
ES8606407A1 true ES8606407A1 (es) 1986-04-01

Family

ID=23896415

Family Applications (1)

Application Number Title Priority Date Filing Date
ES530759A Expired ES8606407A1 (es) 1983-03-21 1984-03-20 Un procedimiento para preparar conjugados de galactosil-insulina

Country Status (6)

Country Link
EP (1) EP0119650A3 (es)
JP (1) JPS6011426A (es)
AU (1) AU2589984A (es)
ES (1) ES8606407A1 (es)
PH (1) PH22300A (es)
ZA (1) ZA842051B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8504099D0 (en) * 1985-02-18 1985-03-20 Wellcome Found Physiologically active substances
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
ID16479A (id) * 1995-06-23 1997-10-02 Oxford Glycosciences Uk Ltd Senyawa-senyawa pengobatan
GB9626450D0 (en) * 1996-12-20 1997-02-05 Oxford Glycosciences Uk Ltd Therapeutic compounds
CA2750223A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
KR101635689B1 (ko) 2009-01-28 2016-07-01 스마트쎌스, 인크. 제어 약물 전달을 위한 접합체 기재 시스템
US8906850B2 (en) 2009-01-28 2014-12-09 Smartcells, Inc. Crystalline insulin-conjugates
WO2010088286A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Synthetic conjugates and uses thereof
US8569231B2 (en) 2009-03-20 2013-10-29 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
EP2408808A4 (en) 2009-03-20 2015-05-06 Smartcells Inc TERMINAL-FUNCTIONALIZED CONJUGATES AND THEIR USE
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
WO2012015692A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
EP2598522A4 (en) 2010-07-28 2014-11-12 Smartcells Inc RECOMBINANT LKTINE, BINDING POINT MODIFIED LECTIN AND APPLICATIONS THEREOF
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
WO2012021512A2 (en) 2010-08-10 2012-02-16 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
TW201605470A (zh) 2013-10-04 2016-02-16 默沙東藥廠 葡萄糖反應性胰島素結合物
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
KR102717969B1 (ko) 2014-02-21 2024-10-15 에꼴 뽈리떼끄닉 뻬데랄 드 로잔느 (으뻬에프엘) 글리코타겟팅 치료제
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US11253579B2 (en) 2017-06-16 2022-02-22 The University Of Chicago Compositions and methods for inducing immune tolerance
EA202092723A1 (ru) 2018-05-09 2021-04-09 Зе Юниверсити Оф Чикаго Композиции и способы, касающиеся иммунной толерантности

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3847890A (en) * 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins
EP0009842B1 (en) * 1978-10-02 1982-11-10 THE PROCTER & GAMBLE COMPANY Liposomes for drug delivery and composition containing a liposome drug system
US4348387A (en) * 1979-07-31 1982-09-07 The Rockefeller University Method and system for the controlled release of biologically active substances to a body fluid

Also Published As

Publication number Publication date
ES530759A0 (es) 1986-04-01
PH22300A (en) 1988-07-22
ZA842051B (en) 1984-10-31
JPS6011426A (ja) 1985-01-21
AU2589984A (en) 1984-09-27
EP0119650A2 (en) 1984-09-26
EP0119650A3 (en) 1987-09-30

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