ES8607331A1 - PROCEDURE FOR PREPARING OXAZAPHOSPHORINE DERIVATIVES - Google Patents

PROCEDURE FOR PREPARING OXAZAPHOSPHORINE DERIVATIVES

Info

Publication number
ES8607331A1
ES8607331A1 ES542606A ES542606A ES8607331A1 ES 8607331 A1 ES8607331 A1 ES 8607331A1 ES 542606 A ES542606 A ES 542606A ES 542606 A ES542606 A ES 542606A ES 8607331 A1 ES8607331 A1 ES 8607331A1
Authority
ES
Spain
Prior art keywords
group
optionally substituted
preparing
procedure
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542606A
Other languages
Spanish (es)
Other versions
ES542606A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Werke AG Chemische Fabrik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Werke AG Chemische Fabrik filed Critical Asta Werke AG Chemische Fabrik
Publication of ES542606A0 publication Critical patent/ES542606A0/en
Publication of ES8607331A1 publication Critical patent/ES8607331A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A novel process for the preparation of oxazaphosphorine derivatives of the general formula < IMAGE > and their neutral salts, by reaction of a compound of the general formula < IMAGE > in which B is the group A or in which B is a C1-C10-alkylmercapto group which is optionally substituted by a carboxyl group, a hydroxyl group or a C1-C4-carbalkoxy group, a benzylmercapto group, a phenylmercapto group which is optionally substituted by methyl or halogen, or a C1-C6-alkanoylthio group, or in which B represents the group -N(OH)-CO-NHR and R denotes hydrogen, a C1-C6-alkyl group, a benzyl group or a phenyl group which is optionally substituted by C1-C4-alkyl radicals or halogen and the group B can also be present in the salt form if it contains an acid group, with an excess of a compound of the formula A'H or A'Y, where A' is different from A and has one of the meanings given for A.
ES542606A 1984-04-27 1985-04-26 PROCEDURE FOR PREPARING OXAZAPHOSPHORINE DERIVATIVES Expired ES8607331A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843415726 DE3415726A1 (en) 1984-04-27 1984-04-27 Process for the preparation of 4-substituted oxazaphosphorine derivatives

Publications (2)

Publication Number Publication Date
ES542606A0 ES542606A0 (en) 1986-05-16
ES8607331A1 true ES8607331A1 (en) 1986-05-16

Family

ID=6234515

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542606A Expired ES8607331A1 (en) 1984-04-27 1985-04-26 PROCEDURE FOR PREPARING OXAZAPHOSPHORINE DERIVATIVES

Country Status (9)

Country Link
AT (1) AT385037B (en)
DD (1) DD232496A5 (en)
DE (1) DE3415726A1 (en)
DK (1) DK188985A (en)
ES (1) ES8607331A1 (en)
FI (1) FI851656A7 (en)
GR (1) GR850994B (en)
HU (1) HUT40676A (en)
PT (1) PT80356B (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3220432A1 (en) * 1981-03-24 1983-12-01 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorine-4-thioalkanesulphonic acid, its neutral salts, process for the preparation thereof and pharmaceutical preparations containing them
DE3111428A1 (en) * 1981-03-24 1982-10-07 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld OXAZAPHOSPHORIN-4-THIO-ALKANESULPHONIC ACIDS AND THEIR NEUTRAL SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3220672A1 (en) * 1981-03-24 1983-12-08 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Cis-oxazaphosphorine-4-thioalkanesulphonic acids, their neutral salts, process for the preparation thereof and pharmaceutical preparations containing them
DE3279834D1 (en) * 1981-12-31 1989-08-31 Asta Pharma Ag 4-sulfido-oxaza phosphorines and their use in the treatment of cancer, and in immunosuppression

Also Published As

Publication number Publication date
PT80356A (en) 1985-05-01
HUT40676A (en) 1987-01-28
ES542606A0 (en) 1986-05-16
FI851656L (en) 1985-10-28
FI851656A7 (en) 1985-10-28
DK188985A (en) 1985-10-28
GR850994B (en) 1985-11-25
DK188985D0 (en) 1985-04-26
DE3415726A1 (en) 1985-10-31
ATA125685A (en) 1987-07-15
AT385037B (en) 1988-02-10
DD232496A5 (en) 1986-01-29
FI851656A0 (en) 1985-04-26
PT80356B (en) 1987-03-16

Similar Documents

Publication Publication Date Title
ES477695A1 (en) Derivatives of dehydrocyclicimino acids
AU537414B2 (en) Pyroglutamic acid derivatives
DK422583A (en) METHOD FOR PREPARING DIAZOBICYCLO (3,3,1) NONANES
ATE47138T1 (en) PROCESS FOR THE PREPARATION OF 1,2-DITHIOLANE-3PENTANS|URE (THIOCTAID).
ES8405796A1 (en) Benzoazacycloalkyl-spiro- imidazolidines
DK182783D0 (en) METHOD FOR PREPARING 1-CARBOXY- (ALKANOYL OR ARALKANOYL) -INDOLINE-2-CARBOXYLIC ACID ESTERS OR SALTS THEREOF
SE7604476L (en) PROCEDURE FOR PREPARING 1- (3,3,3-TRIARYLPROPYL) -4-PHENYL-4-PIPERIDINEMETHANOL COMPOUNDS
ES539505A0 (en) PROCEDURE FOR OBTAINING MURAMILPEPTIDES
DK67384D0 (en) N-IMINOPYRIDINIUM BETAIN DERIVATIVES
ES523890A0 (en) A PROCEDURE FOR PREPARING PENEM DERIVATIVES.
DE69119714D1 (en) Process for the preparation of benzylphthalazinone derivatives and their salts
ES8607331A1 (en) PROCEDURE FOR PREPARING OXAZAPHOSPHORINE DERIVATIVES
ATE185550T1 (en) METHOD FOR PRODUCING IODINATED CONTRAST AGENTS
ATE82747T1 (en) PROCESS FOR THE PREPARATION OF HYDROXYALKYLATING AGENTS, THE AGENTS OBTAINED AND THEIR USE.
ES8505947A1 (en) A PROCEDURE FOR PREPARING SUBSTITUTED DERIVATIVES IN POSITION 1 OF AZETIDIN-3-OL
ATE23989T1 (en) PROCESS FOR THE PREPARATION OF N,N&#39;-BIS(2HYDROXYETHYL)OXAMIDE.
DE69232406D1 (en) Process for the preparation of fluoro-quinoline-3-carboxylic acid derivatives
ATE17851T1 (en) IMIDAZOLYLCARBONIC ACIDS, THEIR DERIVATIVES AND PRODUCTION.
SE8502544L (en) PROCEDURE FOR PREPARING IMIDAZOLIDE INGREDIENTS
DE3470741D1 (en) Azolylmethylcycloacetals, process for their preparation and their use as medicaments
ES544712A0 (en) PROCEDURE FOR OBTAINING IMINOSULFONAMIDES
IL71987A0 (en) Nortropine derivative and its preparation
ES8200658A1 (en) Alkyl ether isothio-uronium salts, process for their preparation and their use as corrosion inhibitors and microbicides.
ES484086A1 (en) Isopropyl amine derivatives, processes for their preparation and medicaments containing them.
GB2018770A (en) Hexahydro-1-mercaptoacyl-1H- azepine-2-carboxylic acids and esters

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102