ES8607727A1 - Procedimiento para la estabilizacion de preparados farmaceuticos en forma de suspensiones conteniendo sucralfato - Google Patents

Procedimiento para la estabilizacion de preparados farmaceuticos en forma de suspensiones conteniendo sucralfato

Info

Publication number
ES8607727A1
ES8607727A1 ES537578A ES537578A ES8607727A1 ES 8607727 A1 ES8607727 A1 ES 8607727A1 ES 537578 A ES537578 A ES 537578A ES 537578 A ES537578 A ES 537578A ES 8607727 A1 ES8607727 A1 ES 8607727A1
Authority
ES
Spain
Prior art keywords
sucralfate
sucralfate suspension
weight
suspension
peptizer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537578A
Other languages
English (en)
Other versions
ES537578A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6243590&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8607727(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES537578A0 publication Critical patent/ES537578A0/es
Publication of ES8607727A1 publication Critical patent/ES8607727A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Graft Or Block Polymers (AREA)
  • Cosmetics (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Glass Compositions (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UNA SUSPENSION ESTABLE DE SUCRALFATO. CONSISTE EN DISOLVER EN AGUA, A UNA TEMPERATURA DE 10 A 40JC Y DE 1 A 12,5% EN PESO, REFERIDO EL SUCRALFATO, DE UN PEPTIZADOR O UNA SAL DE ACIDOS ORGANICOS O INORGANICOS, Y SE SUSPENDE EN LA SOLUCION OBTENIDA, BAJO AGITACION, SUCRALFATO Y EN LA SUSPENSION ASI OBTENIDA, SE INCORPORAN DE 1 A 5% EN PESO DE GOMA DE XANTANO BAJO ULTERIOR AGITACION. LA ACCION DE SUCRALFATO SE PRESENTA POR EFECTOS LIGADORES DE PEPSINA Y EFECTOS ANTIACIDOS, DESARROLLANDO SU ACCION EN EL MEDIO ACIDO DEL TRACTO DIGESTIVO, CON VALORES DE PH INFERIORES A 4, REVISTIENDO LAS MUCOSAS DEL ESTOMAGO Y DEL DUODENO CON UNA CAPA PROTECTORA. LA GOMA DE XANTANO ES UN POLISACARIDO DE ALTO PESO MOLECULAR QUE SE OBTIENE POR LA FERMENTACION DE CARBOHIDRATOS CON MICROBIOS DE PSEUDOMONAS. SE UTILIZA PARA LA CURACION DE ULCERAS.
ES537578A 1984-08-22 1984-11-12 Procedimiento para la estabilizacion de preparados farmaceuticos en forma de suspensiones conteniendo sucralfato Expired ES8607727A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843430809 DE3430809A1 (de) 1984-08-22 1984-08-22 Sucralfat-suspension

Publications (2)

Publication Number Publication Date
ES537578A0 ES537578A0 (es) 1986-01-01
ES8607727A1 true ES8607727A1 (es) 1986-01-01

Family

ID=6243590

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537578A Expired ES8607727A1 (es) 1984-08-22 1984-11-12 Procedimiento para la estabilizacion de preparados farmaceuticos en forma de suspensiones conteniendo sucralfato

Country Status (25)

Country Link
US (1) US4885281A (es)
EP (1) EP0192640B1 (es)
JP (1) JPS61503031A (es)
CN (1) CN85109551A (es)
AT (1) ATE41308T1 (es)
AU (1) AU567257B2 (es)
CA (1) CA1236773A (es)
DE (2) DE3430809A1 (es)
DK (1) DK164479C (es)
ES (1) ES8607727A1 (es)
FI (1) FI80592C (es)
GR (1) GR852023B (es)
HK (1) HK62889A (es)
IE (1) IE58201B1 (es)
IL (1) IL76138A (es)
IN (1) IN164763B (es)
IT (1) IT1178235B (es)
NO (1) NO170126C (es)
NZ (1) NZ213185A (es)
PH (1) PH21250A (es)
PT (1) PT79610A (es)
SG (1) SG35889G (es)
SU (1) SU1544173A3 (es)
WO (1) WO1986001406A1 (es)
ZA (1) ZA848884B (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3714159C2 (de) * 1986-04-30 1996-09-19 Chugai Pharmaceutical Co Ltd Sucralfat-Zubereitung
DK164199C (da) * 1986-05-16 1992-10-19 Chugai Pharmaceutical Co Ltd Sucralfatpraeparat til anvendelse paa oesophagus mucosa
IT1203901B (it) * 1987-04-15 1989-02-23 Lisapharma Spa Composizioni farmaceutiche sotto forma di sospensioni stabili di sucralfato esenti da agenti sospendenti
US5456932A (en) * 1987-04-20 1995-10-10 Fuisz Technologies Ltd. Method of converting a feedstock to a shearform product and product thereof
US5387431A (en) 1991-10-25 1995-02-07 Fuisz Technologies Ltd. Saccharide-based matrix
US5516537A (en) * 1987-04-20 1996-05-14 Fuisz Technologies Ltd. Frozen comestibles
US5422136A (en) * 1987-04-20 1995-06-06 Fuisz Technologies Ltd. Starch-based food enhancing ingredient
US5916880A (en) * 1987-12-21 1999-06-29 Bukh Meditec A/S Reduction of skin wrinkling using sulphated sugars
DK505588D0 (da) * 1988-02-26 1988-09-09 Jesper Hamburger Middel og anvendelse af samme
US5709873A (en) * 1988-02-26 1998-01-20 Niels Bukh A/S Method of treating conditions of teeth and their supporting tissue
US5464828A (en) * 1988-03-02 1995-11-07 Chugai Pharmaceutical Co., Ltd. Aqueous suspension of sucralfate
JP2735559B2 (ja) * 1988-03-02 1998-04-02 中外製薬株式会社 懸濁液
FR2657010B1 (fr) * 1990-01-12 1992-05-15 Pf Medicament Composition pharmaceutique sous forme de suspension aqueuse stable a base de sucrafalte et d'une substance anti-acide ainsi que son procede de preparation.
DE4022944A1 (de) * 1990-07-19 1992-01-23 Merck Patent Gmbh Sucralfat-kautablette
ATE209498T1 (de) * 1990-08-31 2001-12-15 Chugai Pharmaceutical Co Ltd Herstellung einer vorratslösung von in wasser suspendiertem sucralfat
US5196199A (en) * 1990-12-14 1993-03-23 Fuisz Technologies Ltd. Hydrophilic form of perfluoro compounds and method of manufacture
US5268110A (en) * 1991-05-17 1993-12-07 Fuisz Technologies Ltd. Oil removing method
JPH07502050A (ja) * 1991-05-17 1995-03-02 フイズ　テクノロジーズ　リミテッド 新熱可塑性高分子物質及びその製法
US5164379A (en) * 1991-07-15 1992-11-17 Bristol-Myers Company Sucralfate/cyclodextrin complexes
US5576042A (en) 1991-10-25 1996-11-19 Fuisz Technologies Ltd. High intensity particulate polysaccharide based liquids
DE69231281T2 (de) * 1991-12-17 2001-03-01 Biovail Technologies Ltd.(N.D.Ges.D.Staates Delaware), Chantilly Zusammensetzung und verfahren zur ulcusprävention und -behandlung
US5654003A (en) * 1992-03-05 1997-08-05 Fuisz Technologies Ltd. Process and apparatus for making tablets and tablets made therefrom
US5427804A (en) * 1992-03-05 1995-06-27 Fuisz Technologies Ltd. Low-fat edible proteins with maltodextrins and low-saturate oils
US5288508A (en) * 1992-03-20 1994-02-22 Fuisz Technologies, Ltd. Delivery systems containing elastomer solvents subjected to flash flow
CA2095776C (en) * 1992-05-12 2007-07-10 Richard C. Fuisz Rapidly dispersable compositions containing polydextrose
US5728397A (en) * 1992-05-12 1998-03-17 Fuisz Technologies Ltd. Polydextrose product and process
US5279849A (en) * 1992-05-12 1994-01-18 Fuisz Technologies Ltd. Dispersible polydextrose, compositions containing same and method for the preparation thereof
US5348758A (en) * 1992-10-20 1994-09-20 Fuisz Technologies Ltd. Controlled melting point matrix formed with admixtures of a shearform matrix material and an oleaginous material
US5380473A (en) * 1992-10-23 1995-01-10 Fuisz Technologies Ltd. Process for making shearform matrix
US5851553A (en) * 1993-09-10 1998-12-22 Fuisz Technologies, Ltd. Process and apparatus for making rapidly dissolving dosage units and product therefrom
US5895664A (en) * 1993-09-10 1999-04-20 Fuisz Technologies Ltd. Process for forming quickly dispersing comestible unit and product therefrom
US5518551A (en) * 1993-09-10 1996-05-21 Fuisz Technologies Ltd. Spheroidal crystal sugar and method of making
US5622719A (en) * 1993-09-10 1997-04-22 Fuisz Technologies Ltd. Process and apparatus for making rapidly dissolving dosage units and product therefrom
US5597416A (en) * 1993-10-07 1997-01-28 Fuisz Technologies Ltd. Method of making crystalline sugar and products resulting therefrom
US5346377A (en) * 1993-10-07 1994-09-13 Fuisz Technologies Ltd. Apparatus for flash flow processing having feed rate control
US5567439A (en) * 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US6020002A (en) * 1994-06-14 2000-02-01 Fuisz Technologies Ltd. Delivery of controlled-release system(s)
US5445769A (en) * 1994-06-27 1995-08-29 Fuisz Technologies Ltd. Spinner head for flash flow processing
US5582855A (en) * 1994-07-01 1996-12-10 Fuisz Technologies Ltd. Flash flow formed solloid delivery systems
US5843922A (en) * 1994-07-29 1998-12-01 Fuisz Technologies Ltd. Preparation of oligosaccharides and products therefrom
US5556652A (en) 1994-08-05 1996-09-17 Fuisz Technologies Ltd. Comestibles containing stabilized highly odorous flavor component delivery systems
CA2212046A1 (en) * 1995-02-02 1996-08-08 Chugai Seiyaku Kabushiki Kaisha Sucralfate preparations
US5587198A (en) * 1995-05-31 1996-12-24 Fuisz Technologies Ltd. Positive hydration method of preparing confectionery and product therefrom
WO1997028823A1 (en) * 1996-02-08 1997-08-14 Chugai Seiyaku Kabushiki Kaisha Method of using antacid agent and pharmaceutical preparation containing antacid agent
WO2010048981A1 (en) * 2008-10-27 2010-05-06 Laboratorio Italiano Biochimico Farmaceutico Lisapharma S.P.A. Sprayable pharmaceutical compositions comprising sucralfate gel for treating skin or mucosa lesions
ITMI20102366A1 (it) * 2010-12-22 2012-06-23 Italiano Biochimico Far Maceutico Lisa Lab Composizioni farmaceutiche spruzzabili per applicazione topica comprendenti gel di sucralfato
US10716802B2 (en) 2013-03-15 2020-07-21 The Brigham And Women's Hospital, Inc. Compounds to modulate intestinal absorption of nutrients
GR1008308B (el) 2013-05-31 2014-10-02 UNI-PHARMA ΚΛΕΩΝ ΤΣΕΤΗΣ ΦΑΡΜΑΚΕΥΤΙΚΑ ΕΡΓΑΣΤΗΡΙΑ ΑΒΕΕ με δ.τ. "UNI-PHARMA ABEE", Τοπικες φαρμακευτικες και ιατροτεχνολογικες συνθεσεις που περιεχουν συνδυασμους σουκραλφατης, υαλουρονικου οξεος, αργινινης και ενος φυσικου ενυδατικου παραγοντα
JP6365236B2 (ja) * 2014-10-28 2018-08-01 ライオン株式会社 ミクロゲル製剤及びその製造方法
JP6365325B2 (ja) * 2015-01-28 2018-08-01 ライオン株式会社 製剤及びその製造方法
WO2017053970A1 (en) 2015-09-24 2017-03-30 The Brigham And Women's Hospital, Inc. Water-activated mucoadhesive compositions to reduce intestinal absorption of nutrients
CN116763728A (zh) * 2022-03-11 2023-09-19 北京阳光诺和药物研究股份有限公司 一种中和胃酸药物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692898A (en) * 1970-11-05 1972-09-19 Sterling Drug Inc Aqueous magnesium hydroxide suspensions
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
GB2090134A (en) * 1980-12-30 1982-07-07 Geistlich Soehne Ed Ag Pharmaceutical Compositions Containing Guaiacol or Derivatives Thereof
GB2120942B (en) * 1982-05-27 1985-10-30 Glaxo Group Ltd Salbutamol compositions
JPS5978116A (ja) * 1982-10-27 1984-05-04 Chugai Pharmaceut Co Ltd スクラルフェ−ト製剤
CA1218601A (en) * 1983-09-02 1987-03-03 Angel B. Casillan Sucralfate suspension

Also Published As

Publication number Publication date
AU3438284A (en) 1986-03-24
SU1544173A3 (ru) 1990-02-15
IT1178235B (it) 1987-09-09
IN164763B (es) 1989-05-27
FI80592B (fi) 1990-03-30
NO861545L (no) 1986-04-18
SG35889G (en) 1989-10-13
DE3477138D1 (en) 1989-04-20
EP0192640A1 (de) 1986-09-03
US4885281A (en) 1989-12-05
EP0192640B1 (de) 1989-03-15
DK164479B (da) 1992-07-06
WO1986001406A1 (fr) 1986-03-13
GR852023B (es) 1985-12-16
PH21250A (en) 1987-08-31
NO170126B (no) 1992-06-09
JPH0535130B2 (es) 1993-05-25
IE852058L (en) 1986-02-22
IL76138A (en) 1989-09-28
ZA848884B (en) 1985-07-31
ES537578A0 (es) 1986-01-01
FI80592C (fi) 1990-07-10
DK164479C (da) 1992-11-16
DK183386A (da) 1986-04-21
CN85109551A (zh) 1987-05-20
CA1236773A (en) 1988-05-17
IT8449164A0 (it) 1984-11-14
NZ213185A (en) 1988-03-30
HK62889A (en) 1989-08-11
IT8449164A1 (it) 1986-05-14
JPS61503031A (ja) 1986-12-25
IL76138A0 (en) 1985-12-31
FI861674A0 (fi) 1986-04-21
DE3430809A1 (de) 1986-03-06
PT79610A (en) 1985-01-01
DK183386D0 (da) 1986-04-21
NO170126C (no) 1992-09-16
ATE41308T1 (de) 1989-04-15
AU567257B2 (en) 1987-11-12
IE58201B1 (en) 1993-07-28
FI861674L (fi) 1986-04-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051018