ES8702393A1 - Un procedimiento para preparar un derivado de 1-bencil-4- benzhidril-piperazina - Google Patents

Un procedimiento para preparar un derivado de 1-bencil-4- benzhidril-piperazina

Info

Publication number: ES8702393A1
Authority: ES; Spain
Prior art keywords: derivative; benzyl; compounds; processes; production
Prior art date: 1984-03-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES541728A

Other languages

English (en)

Spanish (es)

Other versions

ES541728A0 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kanebo Ltd

Original Assignee

Kanebo Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-03-30

Filing date

1985-03-29

Publication date

1987-01-01

1985-03-29 Application filed by Kanebo Ltd filed Critical Kanebo Ltd

1987-01-01 Publication of ES8702393A1 publication Critical patent/ES8702393A1/es

1987-01-01 Publication of ES541728A0 publication Critical patent/ES541728A0/es

Status Expired legal-status Critical Current

Links

239000004480 active ingredient Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000004885 piperazines Chemical class 0.000 title 1
229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
239000002253 acid Substances 0.000 abstract 4
KUAJKNGLESWEFE-UHFFFAOYSA-N 1-benzhydryl-4-benzylpiperazine Chemical class C=1C=CC=CC=1CN(CC1)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 KUAJKNGLESWEFE-UHFFFAOYSA-N 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
IQXXEPZFOOTTBA-UHFFFAOYSA-N 1-benzylpiperazine Chemical compound C=1C=CC=CC=1CN1CCNCC1 IQXXEPZFOOTTBA-UHFFFAOYSA-N 0.000 abstract 1
150000003935 benzaldehydes Chemical class 0.000 abstract 1
-1 benzyl halide Chemical class 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
229910052731 fluorine Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ES541728A 1984-03-30 1985-03-29 Un procedimiento para preparar un derivado de 1-bencil-4- benzhidril-piperazina Expired ES8702393A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP59064464A JPS60222472A (ja)	1984-03-30	1984-03-30	新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物

Publications (2)

Publication Number	Publication Date
ES8702393A1 true ES8702393A1 (es)	1987-01-01
ES541728A0 ES541728A0 (es)	1987-01-01

Family

ID=13258978

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
ES541728A Expired ES8702393A1 (es)	1984-03-30	1985-03-29	Un procedimiento para preparar un derivado de 1-bencil-4- benzhidril-piperazina
ES556981A Expired ES8801237A1 (es)	1984-03-30	1986-07-29	Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina
ES556980A Expired ES8801236A1 (es)	1984-03-30	1986-07-29	Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
ES556981A Expired ES8801237A1 (es)	1984-03-30	1986-07-29	Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina
ES556980A Expired ES8801236A1 (es)	1984-03-30	1986-07-29	Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina

Country Status (10)

Country	Link
US (1)	US4663325A (2)
EP (1)	EP0159566B1 (2)
JP (1)	JPS60222472A (2)
AT (1)	ATE31411T1 (2)
CA (1)	CA1248110A (2)
DE (1)	DE3561199D1 (2)
ES (3)	ES8702393A1 (2)
FI (1)	FI79101C (2)
GR (1)	GR850787B (2)
NO (1)	NO163185C (2)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61161272A (ja) *	1985-01-11	1986-07-21	Kanebo Ltd	新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
JPS62277370A (ja) *	1986-02-04	1987-12-02	Terumo Corp	ジエン誘導体およびこれを含有する血管拡張剤
FR2614021B1 (fr) *	1987-04-14	1991-03-01	Andre Buzas	Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant
DE4108527A1 (de) *	1991-03-15	1992-09-17	Basf Ag	Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
AU646926B2 (en) *	1991-03-20	1994-03-10	Duphar International Research B.V.	Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity
PT682664E (pt) *	1993-12-08	2001-06-29	Alcon Laboratoires Inc	Compostos possuindo actividade potente como antagonistas do calcio e anti-oxidantes e sua utilizacao como agentes citoprotectores
WO1999038515A1 (en) *	1998-01-29	1999-08-05	Akzo Nobel N.V.	Optic papillary circulation improving agents
RU2204556C2 (ru) *	2001-06-18	2003-05-20	Федеральное государственное унитарное предприятие "Новокузнецкий научно-исследовательский химико-фармацевтический институт"	Способ получения 1-(парахлорбензгидрил)-4-(2-оксиэтил)пиперазина
EP1545519B1 (en)	2002-08-19	2011-03-23	Pfizer Inc.	Combination therapy for hyperproliferative diseases
US7433519B2 (en)	2003-04-04	2008-10-07	Avid Technology, Inc.	Bitstream format for compressed image data
US7403561B2 (en)	2003-04-04	2008-07-22	Avid Technology, Inc.	Fixed bit rate, intraframe compression and decompression of video
US20060135506A1 (en) *	2003-04-22	2006-06-22	Pharmacia Corporation	Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
US20050159403A1 (en) *	2003-04-22	2005-07-21	Pharmacia Corporation	Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage
CN1812983A (zh) *	2003-05-30	2006-08-02	兰贝克赛实验室有限公司	取代的吡咯衍生物及其作为hmg－co抑制剂的用途
US20050037063A1 (en) *	2003-07-21	2005-02-17	Bolton Anthony E.	Combined therapies
WO2006099244A1 (en) *	2005-03-11	2006-09-21	Hong Kong Nitric Oxide Limited	Combination therapy for endothelial dysfunction, angina and diabetes
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7893050B2 (en) *	2005-10-26	2011-02-22	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2351569B1 (en)	2005-10-26	2012-08-22	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
SG166829A1 (en) *	2005-11-08	2010-12-29	Ranbaxy Lab Ltd	Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
WO2008020314A2 (en) *	2006-03-14	2008-02-21	Ranbaxy Laboratories Limited	Statin stabilizing dosage formulations
WO2008010087A2 (en) *	2006-07-14	2008-01-24	Ranbaxy Laboratories Limited	Polymorphic forms of an hmg-coa reductase inhibitor and uses thereof
JP5498168B2 (ja)	2006-12-01	2014-05-21	ブリストル−マイヤーズスクイブカンパニー	アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
AU2008220104B2 (en)	2007-02-28	2012-09-27	Asahi Kasei Pharma Corporation	Sulfonamide derivative
US8883844B2 (en)	2010-09-24	2014-11-11	Nitrogenix Inc.	Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
CN102936233B (zh) *	2012-11-16	2016-01-20	葛长乐	一种1-(二(4-氟苯基)甲基)-4-(2,3,4-三甲氧苯基)哌嗪二盐酸盐晶型
SG11201507496UA (en)	2013-04-17	2015-11-27	Pfizer	N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
US10128077B2 (en) *	2015-10-20	2018-11-13	Korea Research Institute Of Standards And Science	Electron microscope electron gun for facilitating position adjustment and electron microscope including same
CN109666008A (zh) *	2018-12-31	2019-04-23	辰欣药业股份有限公司	一种盐酸洛美利嗪的合成方法
US11248001B2 (en)	2019-01-18	2022-02-15	Astrazeneca Ab	PCSK9 inhibitors and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB705979A (en) *	1951-03-22	1954-03-24	Henri Morren	1.4-aralkyl piperazines and process for the preparation thereof
FR1312427A (fr) *	1961-04-12	1962-12-21	Science Union Et Compagnie Soc	Nouveaux dérivés de la pipérazine et leurs préparations
FR1303080A (fr) *	1961-07-25	1962-09-07	Science Union Et Compagnie Soc	Pipérazines disubstituées
NL7306771A (2) *	1972-06-02	1973-12-04
DE2900810A1 (de) *	1979-01-11	1980-07-24	Cassella Ag	Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung
GB8320701D0 (en) *	1983-08-01	1983-09-01	Wellcome Found	Chemotherapeutic agent

1984
- 1984-03-30 JP JP59064464A patent/JPS60222472A/ja active Granted
1985
- 1985-03-25 US US06/715,813 patent/US4663325A/en not_active Expired - Lifetime
- 1985-03-26 FI FI851217A patent/FI79101C/fi not_active IP Right Cessation
- 1985-03-26 CA CA000477468A patent/CA1248110A/en not_active Expired
- 1985-03-27 EP EP85103707A patent/EP0159566B1/en not_active Expired
- 1985-03-27 AT AT85103707T patent/ATE31411T1/de not_active IP Right Cessation
- 1985-03-27 DE DE8585103707T patent/DE3561199D1/de not_active Expired
- 1985-03-28 GR GR850787A patent/GR850787B/el unknown
- 1985-03-29 NO NO851298A patent/NO163185C/no not_active IP Right Cessation
- 1985-03-29 ES ES541728A patent/ES8702393A1/es not_active Expired
1986
- 1986-07-29 ES ES556981A patent/ES8801237A1/es not_active Expired
- 1986-07-29 ES ES556980A patent/ES8801236A1/es not_active Expired

Also Published As

Publication number	Publication date
US4663325A (en)	1987-05-05
ES8801237A1 (es)	1988-01-01
ES556980A0 (es)	1988-01-01
DE3561199D1 (en)	1988-01-28
JPH0313232B2 (2)	1991-02-22
FI79101C (fi)	1989-11-10
FI851217L (fi)	1985-10-01
ES541728A0 (es)	1987-01-01
NO163185C (no)	1990-04-18
EP0159566B1 (en)	1987-12-16
CA1248110A (en)	1989-01-03
ES556981A0 (es)	1988-01-01
EP0159566A1 (en)	1985-10-30
JPS60222472A (ja)	1985-11-07
FI79101B (fi)	1989-07-31
GR850787B (2)	1985-11-25
FI851217A0 (fi)	1985-03-26
NO851298L (no)	1985-10-01
ES8801236A1 (es)	1988-01-01
ATE31411T1 (de)	1988-01-15

Legal Events

Date	Code	Title	Description
2001-04-01	PC1A	Transfer granted
2007-12-16	FD1A	Patent lapsed	Effective date: 20061014

Publication	Publication Date	Title
ES8801236A1 (es)	1988-01-01	Un procedimiento para preparar un derivado de 1-bencil-4-benzhidrilpiperazina
AU538424B2 (en)	1984-08-16	Piperazino phenylindane
DE3271269D1 (en)	1986-06-26	Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
ATE36699T1 (de)	1988-09-15	Chinonderivate, verfahren zu ihrer herstellung, ihre verwendung und pharmazeutische zusammensetzung.
IE820401L (en)	1982-08-25	N-£4-(indolyl)-piperidino-alkyl\|-benzimidazolines
ES8307760A1 (es)	1983-08-01	Un procedimiento para la preparacion de derivados de 4-anilino-pirimidina.
ATE21246T1 (de)	1986-08-15	Substituierte imidazol-derivate mit pharmakologischer wirkung sowie ihre herstellung und verwendung.
NZ212515A (en)	1988-10-28	Piperazino-pyrimido(5,4-d pyrimidine derivatives and pharmaceutical compositions
EP0066909A3 (en)	1984-03-07	Imidazole derivatives, pharmaceutical compositions containing them and processes for their production
GR860045B (en)	1986-05-12	Novel piperazine derivatives processes for production thereof and pharmaceutical compositions comprising said compounds as active ingredient
IE43641L (en)	1977-04-28	Aroyl-phenylnaphthalenes
GB1433472A (en)	1976-04-28	Biphenylyl ethers and their preparation
IE36485B1 (en)	1976-11-10	Benzothiophene derivatives and process for preparing same
GB1340637A (en)	1973-12-12	Dibenzocycloheptadioxolan derivatives
GB1377610A (en)	1974-12-18	5-piperidine-4-spiro- oxazolidinones method for their preparation and applications thereof
GB1261004A (en)	1972-01-19	Ketones derived from -1-(2-hydroxyethyl)-piperazine
ES464773A1 (es)	1978-09-01	Procedimiento para la preparacion de 2,9-dioxatriciclo (4,3,1,03,7)decanos.
ES8206435A1 (es)	1982-08-16	Procedimiento para la obtencion de un nuevo compuesto deri- vado del acido p-clorofenoxiacetico
PT72255B (de)	1982-07-13	Neue substituierte 4-amino-2,6-diaryl-tetrahydrothiopyrane deren saureadditionssalze verfahren zu ihrer herstellung ihre verwendung und pharmazeutische zusammensetzungen
GB1164496A (en)	1969-09-17	0-Oxaphenanthridine Derivatives and Method for the Preparation
JPS5566577A (en)	1980-05-20	Novel carboxylic derivative and its preparation
JPS54126732A (en)	1979-10-02	Antidepressant containing 2-(3-aminopropoxy)diphenyl ether or its derivative
DK214884A (da)	1984-11-03	Chlorphenoxyacetatderivat