ES8704164A1 - Un procedimiento para la preparacion de derivados de secocantina - Google Patents

Un procedimiento para la preparacion de derivados de secocantina

Info

Publication number
ES8704164A1
ES8704164A1 ES552653A ES552653A ES8704164A1 ES 8704164 A1 ES8704164 A1 ES 8704164A1 ES 552653 A ES552653 A ES 552653A ES 552653 A ES552653 A ES 552653A ES 8704164 A1 ES8704164 A1 ES 8704164A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
phenyl
cycloalkyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552653A
Other languages
English (en)
Other versions
ES552653A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Sobio SA
Original Assignee
Laboratoires Sobio SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Sobio SA filed Critical Laboratoires Sobio SA
Publication of ES552653A0 publication Critical patent/ES552653A0/es
Publication of ES8704164A1 publication Critical patent/ES8704164A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE SECOCANTINA. CONSISTENTE EN LA OBTENCION DE COMPUESTOS DE FORMULA (I), DONDE R1 ES HIDROGENO, ALQUILO, ALCOXI O HALOGENO; R2 Y R3 SON HIDROGENO O, CONJUNTAMENTE, UN ENLACE; R4 Y R5 SON HIDROGENO O UN GRUPO OXO; R7 ES HIDROGENO O ALQUILO; Y R6 SE ESCOGE ENTRE DIFERENTES RADICALES. MEDIANTE LA ALQUILACION DE UN COMPUESTO DE FORMULA (II), OPCIONALMENTE SEGUIDA, O SIMULTANEAMENTE, DE UNA REDUCCION DEL GRUPO OXO R4/R5, DE LA REDUCCION DEL DOBLE ENLACE R2/R3 Y DE LA FORMACION DE UNA SAL DE INTERES FARMACOLOGICO. DE APLICACION POR SU ACTIVIDAD ANTIHIPOXICA Y PARA SUPLIR LA CARENCIA DE OXIGENO CEREBRAL.
ES552653A 1984-06-30 1986-03-04 Un procedimiento para la preparacion de derivados de secocantina Expired ES8704164A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848416724A GB8416724D0 (en) 1984-06-30 1984-06-30 Active compounds

Publications (2)

Publication Number Publication Date
ES552653A0 ES552653A0 (es) 1987-03-16
ES8704164A1 true ES8704164A1 (es) 1987-03-16

Family

ID=10563258

Family Applications (4)

Application Number Title Priority Date Filing Date
ES544729A Expired ES8701157A1 (es) 1984-06-30 1985-06-28 Un procedimiento para la preparacion de derivados de secocantina.
ES552654A Expired ES8704165A1 (es) 1984-06-30 1986-03-04 Un procedimiento para la preparacion de derivados de secocantina
ES552653A Expired ES8704164A1 (es) 1984-06-30 1986-03-04 Un procedimiento para la preparacion de derivados de secocantina
ES552655A Expired ES8704166A1 (es) 1984-06-30 1986-03-04 Un procedimiento para la preparacion de derivados de secocantina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES544729A Expired ES8701157A1 (es) 1984-06-30 1985-06-28 Un procedimiento para la preparacion de derivados de secocantina.
ES552654A Expired ES8704165A1 (es) 1984-06-30 1986-03-04 Un procedimiento para la preparacion de derivados de secocantina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES552655A Expired ES8704166A1 (es) 1984-06-30 1986-03-04 Un procedimiento para la preparacion de derivados de secocantina

Country Status (14)

Country Link
US (1) US4853391A (es)
EP (1) EP0167901B1 (es)
JP (1) JPH0699430B2 (es)
AT (1) ATE51623T1 (es)
AU (1) AU583520B2 (es)
CA (1) CA1296730C (es)
DE (1) DE3576956D1 (es)
ES (4) ES8701157A1 (es)
GB (1) GB8416724D0 (es)
GR (1) GR851602B (es)
IE (1) IE58102B1 (es)
MX (1) MX164198B (es)
NZ (1) NZ212588A (es)
ZA (1) ZA854902B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3677101D1 (de) 1985-06-28 1991-02-28 Beecham Wuelfing Gmbh & Co Kg Tetrahydropyrido-(1,2-a)-indolderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
US4624954A (en) * 1985-12-20 1986-11-25 American Home Products Corporation 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof, useful for the treatment of cognitive impairments
EP0252643A1 (en) 1986-07-01 1988-01-13 BEECHAM - WUELFING GmbH & Co. KG Pyrido[1,2-a]indole derivatives, process for their preparation and pharmaceutical compounds containing them
CA1329597C (en) * 1986-12-22 1994-05-17 Dagmar Hoeltje Derivatives of tetrahydropyrido[1,2-a]indole
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
GB9819035D0 (en) 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
AU767009B2 (en) * 1998-12-11 2003-10-30 Virginia Commonwealth University Selective 5-HT6 receptor ligands
EP1693366A1 (en) * 1998-12-11 2006-08-23 Virginia Commonwealth University Selective 5-HT 6 receptor ligands
EP1132389A1 (en) 2000-03-06 2001-09-12 Vernalis Research Limited New aza-indolyl derivatives for the treatment of obesity
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
BRPI0517955A (pt) 2004-11-01 2008-10-21 Wyeth Corp indolizinas substituìdas e derivados como agentes de snc
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1550496A (en) * 1976-12-31 1979-08-15 Logeais Labor Jacques 1,2,3,3a4,5-hexahydro-canthine derivatives a process for their preparation and their therapeutic applications
US4328343A (en) * 1978-03-13 1982-05-04 The United States Of America As Represented By The Department Of Health And Human Services Cobalt-catalyzed one-step synthesis of annulated pyridines
EP0036269A1 (en) * 1980-03-15 1981-09-23 Beecham Group Plc Substituted benzamides
US4595688A (en) * 1983-06-23 1986-06-17 Mcneilab, Inc. Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof
DE3677101D1 (de) * 1985-06-28 1991-02-28 Beecham Wuelfing Gmbh & Co Kg Tetrahydropyrido-(1,2-a)-indolderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
US4624954A (en) * 1985-12-20 1986-11-25 American Home Products Corporation 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof, useful for the treatment of cognitive impairments

Also Published As

Publication number Publication date
NZ212588A (en) 1989-01-06
ES552655A0 (es) 1987-03-16
EP0167901A2 (en) 1986-01-15
EP0167901B1 (en) 1990-04-04
ES552654A0 (es) 1987-03-16
US4853391A (en) 1989-08-01
AU4424385A (en) 1986-01-02
ES8704165A1 (es) 1987-03-16
ES552653A0 (es) 1987-03-16
ES8704166A1 (es) 1987-03-16
CA1296730C (en) 1992-03-03
IE851633L (en) 1985-12-30
JPS6130587A (ja) 1986-02-12
ZA854902B (en) 1986-05-28
DE3576956D1 (de) 1990-05-10
EP0167901A3 (en) 1987-05-13
ES8701157A1 (es) 1986-11-16
ES544729A0 (es) 1986-11-16
AU583520B2 (en) 1989-05-04
GB8416724D0 (en) 1984-08-01
GR851602B (es) 1985-11-25
JPH0699430B2 (ja) 1994-12-07
ATE51623T1 (de) 1990-04-15
IE58102B1 (en) 1993-06-30
MX164198B (es) 1992-07-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070131