ES8705456A1 - Procedimiento para la obtencion de 4-(3-carboxi-3-diazo-2-oxopropil)azetidin-2-onas - Google Patents

Procedimiento para la obtencion de 4-(3-carboxi-3-diazo-2-oxopropil)azetidin-2-onas

Info

Publication number
ES8705456A1
ES8705456A1 ES553153A ES553153A ES8705456A1 ES 8705456 A1 ES8705456 A1 ES 8705456A1 ES 553153 A ES553153 A ES 553153A ES 553153 A ES553153 A ES 553153A ES 8705456 A1 ES8705456 A1 ES 8705456A1
Authority
ES
Spain
Prior art keywords
preparation
formula
image
products
carbapenem intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553153A
Other languages
English (en)
Other versions
ES553153A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES553153A0 publication Critical patent/ES553153A0/es
Publication of ES8705456A1 publication Critical patent/ES8705456A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE FORMULA (I). CONSISTE EN LA REACCION DE SUSTITUCION, EN REACTOR UNICO, DE 4-ACETOXI-2-AZETIDINONAS, DE FORMULA (II), CON COMPUESTOS DE FORMULA (I), EN LA QUE R1 REPRESENTA HIDROGENO O GRUPO PROTECTOR Y R2, R3 Y R4 PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE Y DE UN AGENTE DE SILILACION, A TEMPERATURAS ENTRE C30JC Y 50JC. ESTOS COMPUESTOS TIENEN APLICACIONES COMO INTERMEDIOS EN LA SINTESIS DE ANTIBIOTICOS DE CARBAPENEM.
ES553153A 1985-03-19 1986-03-19 Procedimiento para la obtencion de 4-(3-carboxi-3-diazo-2-oxopropil)azetidin-2-onas Expired ES8705456A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853509769 DE3509769A1 (de) 1985-03-19 1985-03-19 Verfahren zur herstellung von carbapenemzwischenprodukten

Publications (2)

Publication Number Publication Date
ES553153A0 ES553153A0 (es) 1987-05-01
ES8705456A1 true ES8705456A1 (es) 1987-05-01

Family

ID=6265604

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553153A Expired ES8705456A1 (es) 1985-03-19 1986-03-19 Procedimiento para la obtencion de 4-(3-carboxi-3-diazo-2-oxopropil)azetidin-2-onas

Country Status (7)

Country Link
US (1) US4841042A (es)
EP (1) EP0195963A1 (es)
JP (1) JPS61215367A (es)
KR (1) KR860007213A (es)
DE (1) DE3509769A1 (es)
DK (1) DK123786A (es)
ES (1) ES8705456A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960879A (en) * 1988-03-23 1990-10-02 Shionogi & Co., Ltd. Process for carbapenem intermediates
US5138050A (en) * 1988-06-30 1992-08-11 Merck & Co., Inc. 6-amido-1-methyl carbapenems
EP0350211A3 (en) * 1988-06-30 1990-07-25 Merck & Co. Inc. Novel 6-amido-1-methyl carbapenems
US5395931A (en) * 1988-06-30 1995-03-07 Merck & Co., Inc. 6-amido-1-methyl-2-(substituted-thio)carbapenems
JPH0343707A (ja) * 1989-07-11 1991-02-25 Canon Inc 走査光学装置
US5051502A (en) * 1990-06-06 1991-09-24 University Of Notre Dame Du Lac Rhodium catalyzed cyclization process for bicyclic β-lactams
TW198035B (es) * 1991-05-29 1993-01-11 Hoechst Ag
CN1159809A (zh) * 1994-08-02 1997-09-17 普罗克特和甘保尔公司 喹诺酮基内酰胺抗微生物化合物和新型的中间体化合物的制备方法
BR9508514A (pt) * 1994-08-02 1997-12-23 Procter & Gamble Processo para fabricação de compostos antimicrobiais
JP2003277390A (ja) * 2002-03-25 2003-10-02 Takasago Internatl Corp アゼチジノン化合物の製造方法
CN105906529B (zh) * 2016-06-07 2018-11-27 江西富祥药业股份有限公司 4-卤代-2-重氮-3-氧代-戊酸(4-硝基苯)甲酯及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4312871A (en) * 1979-12-03 1982-01-26 Merck & Co., Inc. 6-, 1- And 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
DE3167774D1 (en) * 1980-02-28 1985-01-31 Fujisawa Pharmaceutical Co 4-substituted-2-oxoazetidine compounds, processes for their preparation, and their use for preparing antibiotics
US4382949A (en) * 1980-07-31 1983-05-10 Schering Corporation 2-(Amino acid-thio)-1-carbapen-2-em-3-carboxylic acids and congeners
CA1190236A (en) * 1981-10-23 1985-07-09 Edward J.J. Grabowski Antibiotic synthesis

Also Published As

Publication number Publication date
ES553153A0 (es) 1987-05-01
DK123786A (da) 1986-09-20
US4841042A (en) 1989-06-20
DE3509769A1 (de) 1986-09-25
JPS61215367A (ja) 1986-09-25
KR860007213A (ko) 1986-10-08
DK123786D0 (da) 1986-03-18
EP0195963A1 (de) 1986-10-01

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