ES8706607A1 - Procedimiento para preparar 2-,3- y 4-bifeniloxiaminoalcanosy compuestos afines como agentes anti-inflamatorios,analge- sicos y anti-psoriaticos - Google Patents

Procedimiento para preparar 2-,3- y 4-bifeniloxiaminoalcanosy compuestos afines como agentes anti-inflamatorios,analge- sicos y anti-psoriaticos

Info

Publication number
ES8706607A1
ES8706607A1 ES550876A ES550876A ES8706607A1 ES 8706607 A1 ES8706607 A1 ES 8706607A1 ES 550876 A ES550876 A ES 550876A ES 550876 A ES550876 A ES 550876A ES 8706607 A1 ES8706607 A1 ES 8706607A1
Authority
ES
Spain
Prior art keywords
integer
biphenyloxyaminoalkanes
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550876A
Other languages
English (en)
Other versions
ES550876A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/597,790 external-priority patent/US4792570A/en
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES8706607A1 publication Critical patent/ES8706607A1/es
Publication of ES550876A0 publication Critical patent/ES550876A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO DE PREPARAR 2-, 3- Y 4-BIFENILOXIAMINOALCANOS. CONSISTE EN HIDROLIZAR UN COMPUESTO DE FORMULA (II) PARA OBTENER UN COMPUESTO DE FORMULA (I) EN LA QUE B -NH2, Y OPCIONALMENTE CONVERTIR LA BASE LIBRE DEL COMPUESTO DE FORMULA DE FORMULA (I) EN UN ACIDO O UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE, DONDE A ES UN ENTERO DE 0 A 3; B ES UN ENTERO DE 0 A 2; N ES UN ENTERO DE 3 A 12; CADA X Y CADA Y SON INDEPENDIENTEMENTE HALOGENO, R ELEVADO A 1, ALCOXI O FENILO; Y B ES UN GRUPO DE FORMULAS -NR ELEVADO A 1 R ELEVADO A 2, -NR ELEVADO A 1(CH2CH2OH) Y OTROS. TIENEN APLICACIONES FARMACEUTICAS COMO ANALGESICOS, ANTI-INFLAMATORIOS Y ANTI-POTASICOS. *FORMULA*
ES550876A 1984-04-06 1986-01-14 Procedimiento para preparar 2-,3- y 4-bifeniloxiaminoalcanosy compuestos afines como agentes anti-inflamatorios,analge- sicos y anti-psoriaticos Expired ES8706607A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59728284A 1984-04-06 1984-04-06
US06/597,790 US4792570A (en) 1984-04-06 1984-04-06 3- and 4-biphenyloxyaminoalkanes and related compounds as anti-inflammatory and analgetic agents

Publications (2)

Publication Number Publication Date
ES8706607A1 true ES8706607A1 (es) 1987-07-01
ES550876A0 ES550876A0 (es) 1987-07-01

Family

ID=27082786

Family Applications (1)

Application Number Title Priority Date Filing Date
ES550876A Expired ES8706607A1 (es) 1984-04-06 1986-01-14 Procedimiento para preparar 2-,3- y 4-bifeniloxiaminoalcanosy compuestos afines como agentes anti-inflamatorios,analge- sicos y anti-psoriaticos

Country Status (2)

Country Link
EP (1) EP0157652A1 (es)
ES (1) ES8706607A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6316475B1 (en) * 2000-11-17 2001-11-13 Abbott Laboratories Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications
US8425885B2 (en) 2009-11-09 2013-04-23 Conopco, Inc. Substituted 3-(phenoxymethyl) benzyl amines and personal care compositions
US8309064B2 (en) * 2009-11-09 2012-11-13 Conopco, Inc. Skin care compositions comprising phenoxyalkyl amines
US11708530B2 (en) 2017-10-31 2023-07-25 The Regents Of The University Of California Organic ligands for templatable mesoscale nanocapsules

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2870150A (en) * 1954-11-29 1959-01-20 Abbott Lab Morpholine ethers
JPS598265B2 (ja) * 1975-06-19 1984-02-23 三菱化学株式会社 オメガ − アミノアルコキシビフエニルルイ マタハ ソノサンフカエンノセイゾウホウ
CH637106A5 (en) * 1978-01-03 1983-07-15 Mitsubishi Chem Ind Aminoalkoxybenzene derivatives, a process for their preparation, and drugs
EP0082005A3 (en) * 1981-12-14 1983-08-03 Syntex (U.S.A.) Inc. Naphthoxyalkylamines and related compounds, their preparation and antiinflammatory compositions containing them

Also Published As

Publication number Publication date
EP0157652A1 (en) 1985-10-09
ES550876A0 (es) 1987-07-01

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