ES8800152A1 - Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas - Google Patents
Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidasInfo
- Publication number
- ES8800152A1 ES8800152A1 ES553050A ES553050A ES8800152A1 ES 8800152 A1 ES8800152 A1 ES 8800152A1 ES 553050 A ES553050 A ES 553050A ES 553050 A ES553050 A ES 553050A ES 8800152 A1 ES8800152 A1 ES 8800152A1
- Authority
- ES
- Spain
- Prior art keywords
- thio
- halogen
- formula
- alk
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 150000003857 carboxamides Chemical class 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- -1 hydroxy, hydroxy Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005239 aroylamino group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
- C07D203/18—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carboxylic acids, or by sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE N-(PIPERIDINIL-ALQUIL)-CARBOXAMIDAS, DE FORMULA (I) Y DE SUS SALES. CONSISTE EN LA REACCION DE CONDENSACION INTERMOLECULAR DE COMPUESTOS DE FORMULA (II) Y (III) PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LAS QUE R, ALK, AR1 Y AR2 PUEDEN SER VARIOS TIPOS DE RADICALES, X2 Y X3 JUNTOS REPRESENTAN ALQUILENO CON 2 A 7 ATOMOS DE CARBONO Y X4 ES HIDROGENO; LA CONDENSACION SE EFECTUA EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA COMPRENDIDA ENTRE 0GC Y 200GC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIPSICOTICOS. *FORMULA*
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH125883 | 1983-03-09 | ||
| CH392583 | 1983-07-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES553050A0 ES553050A0 (es) | 1987-10-16 |
| ES8800152A1 true ES8800152A1 (es) | 1987-10-16 |
Family
ID=25687141
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES84530358A Granted ES530358A0 (es) | 1983-03-09 | 1984-03-07 | Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas. |
| ES85544713A Expired ES8702890A1 (es) | 1983-03-09 | 1985-06-28 | Procedimiento para la obtencion de n-(piperidinil-alquil)- carboxamidas |
| ES553050A Expired ES8800152A1 (es) | 1983-03-09 | 1986-03-14 | Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES84530358A Granted ES530358A0 (es) | 1983-03-09 | 1984-03-07 | Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas. |
| ES85544713A Expired ES8702890A1 (es) | 1983-03-09 | 1985-06-28 | Procedimiento para la obtencion de n-(piperidinil-alquil)- carboxamidas |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4559349A (es) |
| EP (1) | EP0124476B1 (es) |
| KR (1) | KR900008674B1 (es) |
| AR (1) | AR242185A1 (es) |
| AU (1) | AU583470B2 (es) |
| CA (1) | CA1273929A (es) |
| CY (1) | CY1576A (es) |
| DD (1) | DD220308A5 (es) |
| DE (1) | DE3472251D1 (es) |
| DK (1) | DK159420C (es) |
| ES (3) | ES530358A0 (es) |
| FI (1) | FI80019C (es) |
| HK (1) | HK18491A (es) |
| HU (1) | HU191591B (es) |
| IE (1) | IE57057B1 (es) |
| IL (1) | IL71185A (es) |
| NO (1) | NO164349C (es) |
| NZ (1) | NZ207428A (es) |
| PH (1) | PH21416A (es) |
| PT (1) | PT78212B (es) |
| SG (1) | SG91490G (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0177078A1 (en) * | 1984-09-12 | 1986-04-09 | Duphar International Research B.V | Spasmolytically active tertiary amine derivatives and method of preparing the same |
| US4772630A (en) * | 1984-11-23 | 1988-09-20 | Ciba-Geigy Corp. | Benzamides and their salts |
| FR2581993B1 (fr) * | 1985-05-14 | 1988-03-18 | Synthelabo | Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique |
| US4900841A (en) * | 1987-04-20 | 1990-02-13 | Schering A.G. | 1-[4-[(methyl-sulfonyl)amino]benzoyl]aziridine |
| EP0294183B1 (en) * | 1987-06-02 | 1994-03-30 | Ajinomoto Co., Inc. | Use of ethylamine derivatives as antihypertensive agents |
| US4990511A (en) * | 1988-08-03 | 1991-02-05 | Takeda Chemical Industries, Ltd. | Amide compounds, their production and use |
| IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| FR2676226B1 (fr) * | 1991-05-03 | 1993-08-27 | Sanofi Elf | Nouveaux intermediaires pour la synthese de composes dialkylenepiperidino. |
| WO1993016081A1 (en) * | 1992-02-13 | 1993-08-19 | Merrell Dow Pharmaceuticals Inc. | Piperidinyl thiacyclic derivatives |
| EP0661266A1 (en) * | 1993-12-27 | 1995-07-05 | Toa Eiyo Ltd. | Substituted cyclic amine compounds as 5HT2 antagonists |
| US5728835A (en) * | 1993-12-27 | 1998-03-17 | Toa Eiyo, Ltd. | Substituted cyclic amine compound, production process thereof and pharmaceutical composition for circulatory organ use containing the same |
| IL125658A0 (en) | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| US6339087B1 (en) | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
| DE69921351T2 (de) * | 1998-11-17 | 2006-03-09 | F. Hoffmann-La Roche Ag | 4-Aroyl-Piperidin-CCR-3 Rezeptorantagonisten III |
| CA2351631A1 (en) | 1998-11-20 | 2000-06-02 | F. Hoffmann-La Roche Ag | Piperidine quaternary salts-ccr-3 receptor antagonists |
| US6518286B1 (en) * | 1999-03-26 | 2003-02-11 | Astrazeneca Ab | Compounds |
| GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
| GB0021670D0 (en) | 2000-09-04 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
| US6770659B2 (en) * | 2002-08-26 | 2004-08-03 | Sk Corporation | Benzoyl piperidine compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE635597A (es) * | 1962-03-01 | |||
| US3632767A (en) * | 1968-02-12 | 1972-01-04 | Mallinckrodt Chemical Works | Treatment of depression with 4-substituted piperidines |
| US3956296A (en) * | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
| US4335127A (en) * | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
| FI853477L (fi) * | 1984-09-14 | 1986-03-15 | Ciba Geigy Ag | Foerfarande foer framstaellning av karbonylfoereningar. |
| EP0181793B1 (fr) * | 1984-10-16 | 1988-07-27 | Synthelabo | Dérivés de pipéridine, leur préparation et leur application en thérapeutique |
-
1984
- 1984-02-28 DK DK114684A patent/DK159420C/da not_active IP Right Cessation
- 1984-03-05 DE DE8484810109T patent/DE3472251D1/de not_active Expired
- 1984-03-05 FI FI840867A patent/FI80019C/fi not_active IP Right Cessation
- 1984-03-05 US US06/586,493 patent/US4559349A/en not_active Expired - Lifetime
- 1984-03-05 EP EP84810109A patent/EP0124476B1/de not_active Expired
- 1984-03-07 ES ES84530358A patent/ES530358A0/es active Granted
- 1984-03-07 CA CA000449025A patent/CA1273929A/en not_active Expired
- 1984-03-07 DD DD84260660A patent/DD220308A5/de not_active IP Right Cessation
- 1984-03-07 PT PT78212A patent/PT78212B/pt not_active IP Right Cessation
- 1984-03-08 PH PH30367A patent/PH21416A/en unknown
- 1984-03-08 IE IE563/84A patent/IE57057B1/en not_active IP Right Cessation
- 1984-03-08 AU AU25424/84A patent/AU583470B2/en not_active Ceased
- 1984-03-08 NZ NZ207428A patent/NZ207428A/en unknown
- 1984-03-08 IL IL71185A patent/IL71185A/xx not_active IP Right Cessation
- 1984-03-08 NO NO840889A patent/NO164349C/no unknown
- 1984-03-08 HU HU84935A patent/HU191591B/hu not_active IP Right Cessation
- 1984-03-09 KR KR1019840001204A patent/KR900008674B1/ko not_active Expired
-
1985
- 1985-06-28 ES ES85544713A patent/ES8702890A1/es not_active Expired
-
1986
- 1986-03-14 ES ES553050A patent/ES8800152A1/es not_active Expired
- 1986-08-08 AR AR86304848A patent/AR242185A1/es active
-
1990
- 1990-11-13 SG SG914/90A patent/SG91490G/en unknown
-
1991
- 1991-03-14 HK HK184/91A patent/HK18491A/xx not_active IP Right Cessation
- 1991-12-20 CY CY1576A patent/CY1576A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted | ||
| FD1A | Patent lapsed |
Effective date: 20001102 |