ES8800209A1 - Anti-cancer compsn. contg. 5-fluoro-uracil or cpd. forming it in vivo - Google Patents
Anti-cancer compsn. contg. 5-fluoro-uracil or cpd. forming it in vivoInfo
- Publication number
- ES8800209A1 ES8800209A1 ES557310A ES557310A ES8800209A1 ES 8800209 A1 ES8800209 A1 ES 8800209A1 ES 557310 A ES557310 A ES 557310A ES 557310 A ES557310 A ES 557310A ES 8800209 A1 ES8800209 A1 ES 8800209A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- cpd
- alkylcarbamoyl
- iii
- vivo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001093 anti-cancer Effects 0.000 title abstract 2
- 229960002949 fluorouracil Drugs 0.000 title abstract 2
- 238000001727 in vivo Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 2
- JGLMVXWAHNTPRF-CMDGGOBGSA-N CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O Chemical compound CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O JGLMVXWAHNTPRF-CMDGGOBGSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- -1 phenylcarbamoyl Chemical group 0.000 abstract 1
- 125000005633 phthalidyl group Chemical group 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 238000003419 tautomerization reaction Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Anticancer compsn. comprises 5-fluorouracil (I) or a cpd. (II) capable of producing (I) in vivo together with a pyridine deriv. of formula (III). In (III) R1 = OH or acyloxy; R2, R4 = H, halogen, NH2, COOH, CONH2, CN, NO2, 1-6C alkyl, 2-6C alkenyl or (1-6C)alkoxycarbonyl; R3, R5 = H, OH or acyloxy. When at least one of R1, R3 and R5 = OH, then the 1-posn. of the (III) ring may have the -NH- structure by keto-enol tautomerism, and this H atom may be replaced by 1-6C alkyl, tetrahydrofuranyl, tetrahydropyranyl, (1-6C) alkoxy-(1-6C)alkyl, phthalidyl, CONH2, (1-6C)alkoxycarbonyl-(1-6C)alkylcarbamoyl, Ph-(1-6C)alkoxy-(1-6C)alkyl, phenylcarbamoyl (itself opt. ring substd.), (1-6C)alkylcarbamoyl, COOH-(1-6C)alkylcarbamoyl, (1-6C)alkylthio-(1-6C)alkyl or 2-6C alkenyl. Provided that (III) is not a cpd. of formula (IV), where R = H, 1-6C alkyl, tetrahydrofuranyl, tetrahydropyranyl, (1-6C)alkoxy-(1-6C)alkyl, (1-6C)alkylcarbamoyl, (1-6C)alkylthio-(1-6C)alkyl or 2-6C alkenyl.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59229938A JPS61106593A (en) | 1984-10-30 | 1984-10-30 | 2'-deoxy-5-fluorouridine derivative |
| JP25458784 | 1984-11-30 | ||
| JP719085 | 1985-01-17 | ||
| JP5978885 | 1985-03-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES557310A0 ES557310A0 (en) | 1987-11-16 |
| ES8800209A1 true ES8800209A1 (en) | 1987-11-16 |
Family
ID=27454662
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557311A Expired ES8800210A1 (en) | 1984-10-30 | 1987-01-14 | Anti-cancer compsn. contg. 5-fluoro-uracil or cpd. forming it in vivo |
| ES557309A Expired ES8800213A1 (en) | 1984-10-30 | 1987-01-14 | Anti-cancer compsn. contg. 5-fluoro-uracil or cpd. forming it in vivo |
| ES557310A Expired ES8800209A1 (en) | 1984-10-30 | 1987-01-14 | Anti-cancer compsn. contg. 5-fluoro-uracil or cpd. forming it in vivo |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557311A Expired ES8800210A1 (en) | 1984-10-30 | 1987-01-14 | Anti-cancer compsn. contg. 5-fluoro-uracil or cpd. forming it in vivo |
| ES557309A Expired ES8800213A1 (en) | 1984-10-30 | 1987-01-14 | Anti-cancer compsn. contg. 5-fluoro-uracil or cpd. forming it in vivo |
Country Status (1)
| Country | Link |
|---|---|
| ES (3) | ES8800210A1 (en) |
-
1987
- 1987-01-14 ES ES557311A patent/ES8800210A1/en not_active Expired
- 1987-01-14 ES ES557309A patent/ES8800213A1/en not_active Expired
- 1987-01-14 ES ES557310A patent/ES8800209A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES557309A0 (en) | 1987-11-16 |
| ES557310A0 (en) | 1987-11-16 |
| ES8800210A1 (en) | 1987-11-16 |
| ES557311A0 (en) | 1987-11-16 |
| ES8800213A1 (en) | 1987-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20060930 |