ES8800437A1 - Un procedimiento para la produccion de un conjugado marcado con un trazador de metalotioneina y una molecula biologicamente activa - Google Patents

Un procedimiento para la produccion de un conjugado marcado con un trazador de metalotioneina y una molecula biologicamente activa

Info

Publication number
ES8800437A1
ES8800437A1 ES553685A ES553685A ES8800437A1 ES 8800437 A1 ES8800437 A1 ES 8800437A1 ES 553685 A ES553685 A ES 553685A ES 553685 A ES553685 A ES 553685A ES 8800437 A1 ES8800437 A1 ES 8800437A1
Authority
ES
Spain
Prior art keywords
tracer
conjugate
procedure
biologically active
metalotioneine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553685A
Other languages
English (en)
Other versions
ES553685A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES8800437A1 publication Critical patent/ES8800437A1/es
Publication of ES553685A0 publication Critical patent/ES553685A0/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR UN CONJUGADO MARCADO CON UN TRAZADO DE METALOTIONEINA Y UNA MOLECULA BIOLOGICAMENTE ACTIVA. COMPRENDE: A) CONJUGAR LA MBA CON UN AGENTE ENTRECRUZANTE HETEROBIFUNCIONAL DE FORMULA (X-Y-Z); B) TRATAR AL CONJUGADO DE A) CON METALOTIONEINA, EN AGUA, A PH DE 3 A 11 Y ENTRE 0 Y 60GC, PARA FORMAR UN CONJUGADO; Y C) INCORPORAR EN LA TIONEINA DEL CONJUGADO DE B) UN TRAZADOR. EL MBA ES UN ANTICUERPO Y EL TRAZADOR ES METAL SELECCIONADO ENTRE TECNECIO-99-M, RUTENIO-97, Y PLOMO-203. SIENDO: X, UN RADICAL REACTIVO CON LOS GRUPOS -NH2 -OH; Y, UN RADICAL REACTIVO DE TIOLES; Y Z, ALQUILO, ARILO, CICLOALQUILO DE C 1 A 20 Y OTROS. SE UTILIZA EN MEDICINA CON FINES DE DIAGNOSTICO. I
ES553685A 1985-04-03 1986-04-03 Un procedimiento para la produccion de un conjugado marcado con un trazador de metalotioneina y una molecula biologicamente activa Expired ES8800437A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71943685A 1985-04-03 1985-04-03

Publications (2)

Publication Number Publication Date
ES8800437A1 true ES8800437A1 (es) 1987-10-16
ES553685A0 ES553685A0 (es) 1987-10-16

Family

ID=24890070

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553685A Expired ES8800437A1 (es) 1985-04-03 1986-04-03 Un procedimiento para la produccion de un conjugado marcado con un trazador de metalotioneina y una molecula biologicamente activa

Country Status (15)

Country Link
EP (1) EP0196669B1 (es)
JP (1) JPS61236733A (es)
KR (1) KR930003312B1 (es)
AT (1) ATE72569T1 (es)
AU (1) AU603981B2 (es)
DE (1) DE3683861D1 (es)
DK (1) DK148586A (es)
ES (1) ES8800437A1 (es)
FI (1) FI861424L (es)
GR (1) GR860876B (es)
IE (1) IE58425B1 (es)
IL (1) IL78377A0 (es)
MX (1) MX168179B (es)
NO (1) NO167124C (es)
ZA (1) ZA862417B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
US5053493A (en) * 1987-04-02 1991-10-01 Centocor Cardiovascular Imaging Partners, L.P. Method for labeling antibodies with a metal ion
US5177192A (en) * 1987-04-02 1993-01-05 Centocor, Incorporated Method for labeling antibodies with a metal ion
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5759515A (en) * 1989-08-09 1998-06-02 Rhomed Incorporated Polyvalent peptide pharmaceutical applications
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5219556A (en) * 1990-07-09 1993-06-15 Mallinckrodt Medical, Inc. Stabilized therapeutic radiopharmaceutical complexes
US5194594A (en) * 1990-09-07 1993-03-16 Techniclone, Inc. Modified antibodies
CA2048078A1 (en) * 1990-11-15 1992-05-16 Wolfgang A. Wrasidlo Chemical modification of antibodies for creation of immunoconjugates
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
DE69231586T2 (de) * 1992-01-03 2001-07-19 Rhomed, Inc. Pharmazeutische anwendungen auf der basis von peptid-metall-ionen
CN1314966C (zh) * 2004-12-03 2007-05-09 湖南农业大学 一种猪金属硫蛋白的检测方法
JP5202443B2 (ja) * 2009-06-01 2013-06-05 興和株式会社 有害金属測定試薬及び測定方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732864A (en) * 1983-10-06 1988-03-22 E. I. Du Pont De Nemours And Company Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules
JP2871813B2 (ja) * 1990-07-03 1999-03-17 古河電気工業株式会社 クロスヘッドの角度調整装置

Also Published As

Publication number Publication date
EP0196669B1 (en) 1992-02-12
EP0196669A3 (en) 1988-09-14
NO167124B (no) 1991-07-01
KR860008203A (ko) 1986-11-12
MX168179B (es) 1993-05-10
ATE72569T1 (de) 1992-02-15
AU5552486A (en) 1986-10-09
IE58425B1 (en) 1993-09-22
ES553685A0 (es) 1987-10-16
ZA862417B (en) 1987-12-30
EP0196669A2 (en) 1986-10-08
FI861424A7 (fi) 1986-10-04
AU603981B2 (en) 1990-12-06
NO167124C (no) 1991-10-09
FI861424L (fi) 1986-10-04
IE860853L (en) 1986-10-03
DK148586A (da) 1986-10-04
GR860876B (en) 1986-07-29
IL78377A0 (en) 1986-07-31
DK148586D0 (da) 1986-04-02
FI861424A0 (fi) 1986-04-02
NO861200L (no) 1986-10-06
JPS61236733A (ja) 1986-10-22
DE3683861D1 (de) 1992-03-26
KR930003312B1 (ko) 1993-04-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612