ES8801182A1 - Un procedimiento para la preparacion de derivados aminicos - Google Patents

Un procedimiento para la preparacion de derivados aminicos

Info

Publication number
ES8801182A1
ES8801182A1 ES557019A ES557019A ES8801182A1 ES 8801182 A1 ES8801182 A1 ES 8801182A1 ES 557019 A ES557019 A ES 557019A ES 557019 A ES557019 A ES 557019A ES 8801182 A1 ES8801182 A1 ES 8801182A1
Authority
ES
Spain
Prior art keywords
represent
phenyl
halogen
alkyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557019A
Other languages
English (en)
Other versions
ES557019A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858500926A external-priority patent/GB8500926D0/en
Priority claimed from GB858500927A external-priority patent/GB8500927D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES557019A0 publication Critical patent/ES557019A0/es
Publication of ES8801182A1 publication Critical patent/ES8801182A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE PREPARAR DERIVADOS AMINICOS. CONSISTE EN HACER REACCIONAR COMPUESTOS DE FORMULAS AR(CH2)2NHR9 Y R10NHCR2R3CR4R5Y1 CON UN AGENTE ALQUILANTE, EN UN DISOLVENTE Y EN UN INTERVALO DE TEMPERATURAS ENTRE C5 Y 100JC; Y ELIMINAR CUALQUIER GRUPO PROTECTOR PRESENTE EN UN INTERMEDIO DE FORMULA (II), PARA OBTENER DERIVADOS AMINICOS DE FORMULA (I), DONDE R1 ES HALOGENO O UN GRUPO METILO, ETILO, N-PROPILO O N-BUTILO; R2, R3, R4 Y R5 SON CADA UNO DE ELLOS, H, O UNO DE ELLOS ES UN GRUPO METILO O ETILO; X ES UNA CADENA ALQUILENO DE C 4 A 7 Y OTROS; E Y ES UN ANILLO FENILICO Y OTROS. TIENEN APLICACIONES FARMACEUTICAS PARA DISMINUIR LA RESISTENCIA VASCULAR.
ES557019A 1985-01-15 1986-08-14 Un procedimiento para la preparacion de derivados aminicos Expired ES8801182A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858500926A GB8500926D0 (en) 1985-01-15 1985-01-15 Chemical compounds
GB858500927A GB8500927D0 (en) 1985-01-15 1985-01-15 Chemical compounds

Publications (2)

Publication Number Publication Date
ES557019A0 ES557019A0 (es) 1987-12-16
ES8801182A1 true ES8801182A1 (es) 1987-12-16

Family

ID=26288665

Family Applications (2)

Application Number Title Priority Date Filing Date
ES550874A Expired ES8704873A1 (es) 1985-01-15 1986-01-14 Un procedimiento para la preparacion de 3,4-dihidroxifemetilamino derivados 2-ustituidos.
ES557019A Expired ES8801182A1 (es) 1985-01-15 1986-08-14 Un procedimiento para la preparacion de derivados aminicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES550874A Expired ES8704873A1 (es) 1985-01-15 1986-01-14 Un procedimiento para la preparacion de 3,4-dihidroxifemetilamino derivados 2-ustituidos.

Country Status (9)

Country Link
US (1) US5023378A (es)
EP (1) EP0188361B1 (es)
AU (1) AU587217B2 (es)
CA (1) CA1281036C (es)
DE (1) DE3677787D1 (es)
DK (1) DK17386A (es)
ES (2) ES8704873A1 (es)
IL (1) IL77594A (es)
NZ (1) NZ214823A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3679784D1 (de) * 1985-11-20 1991-07-18 Fisons Plc Catecholamin-derivate, verfahren zu deren herstellung und deren pharmazeutische zusammensetzungen.
DE3874206D1 (de) * 1987-05-19 1992-10-08 Fisons Plc 2-(3-4-dihydroxyphenyl)-aethylamine, ihre herstellung und ihre verwendung als arzneimittel.
US5281623A (en) * 1990-08-27 1994-01-25 Eli Lilly And Company Method for treating inflammation
US5441984A (en) * 1994-01-06 1995-08-15 Eli Lilly And Company Urea, thiourea and guanidine derivatives
SG99290A1 (en) * 1996-04-09 2003-10-27 Nps Pharma Inc Calcilytic compounds
US6818660B2 (en) 1996-04-09 2004-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
US7202261B2 (en) 1996-12-03 2007-04-10 Nps Pharmaceuticals, Inc. Calcilytic compounds
TW483881B (en) 1996-12-03 2002-04-21 Nps Pharma Inc Calcilytic compounds
EP3658129A4 (en) * 2017-07-25 2021-08-25 The Board of Trustees of the Leland Stanford Junior University GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) MODULATORS AND METHODS OF TREATMENT OF G6PD DEFICIENCY

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2653977A (en) * 1953-09-29 Chxnx
GB987438A (en) * 1961-10-10 1965-03-31 Frosst & Co Charles E N,n-disubstituted-1,3-diamino-propanes and 2-propanols
NL130078C (es) * 1963-06-11
CH517694A (de) * 1968-12-03 1972-01-15 Boehringer Sohn Ingelheim Verfahren zur Herstellung neuer substituierter Polymethylendiamine
US3789072A (en) * 1970-04-22 1974-01-29 Squibb & Sons Inc Carboxamides
US4024281A (en) * 1972-05-26 1977-05-17 Smithkline Corporation N,N-bis[2-(3-substituted-4-hydroxyphenyl)-ethyl or -2-hydroxyethyl]-polymethylenediamines
DK449974A (es) * 1973-08-31 1975-04-28 Sandoz Ag
US4155907A (en) * 1976-08-16 1979-05-22 The Dow Chemical Company Method for inhibiting ADP-induced platelet aggregation using phenylthioalkylamines
DE3263531D1 (en) * 1981-08-05 1985-06-20 Fisons Plc Amine derivatives, processes for their production and pharmaceutical compositions containing them
FI843507L (fi) * 1983-01-21 1984-09-07 Fisons Plc Aromatiska aminer.
EP0375668A3 (en) * 1983-10-25 1990-10-17 FISONS plc Phenylethylamines, process for their preparation and compositions containing them
US4657929A (en) * 1983-10-25 1987-04-14 Fisons Plc Compounds

Also Published As

Publication number Publication date
ES550874A0 (es) 1987-04-16
DE3677787D1 (de) 1991-04-11
ES8704873A1 (es) 1987-04-16
EP0188361A1 (en) 1986-07-23
EP0188361B1 (en) 1991-03-06
ES557019A0 (es) 1987-12-16
NZ214823A (en) 1989-08-29
US5023378A (en) 1991-06-11
DK17386D0 (da) 1986-01-14
IL77594A (en) 1989-12-15
AU587217B2 (en) 1989-08-10
AU5228986A (en) 1986-07-24
DK17386A (da) 1986-07-16
CA1281036C (en) 1991-03-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401