ES8801276A1 - Procedimiento para preparar nuevos derivados imidazo - Google Patents
Procedimiento para preparar nuevos derivados imidazoInfo
- Publication number
- ES8801276A1 ES8801276A1 ES556974A ES556974A ES8801276A1 ES 8801276 A1 ES8801276 A1 ES 8801276A1 ES 556974 A ES556974 A ES 556974A ES 556974 A ES556974 A ES 556974A ES 8801276 A1 ES8801276 A1 ES 8801276A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- preparation
- reaction
- methines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE IMIDAZO, DE SUS SALES DE ADICION DE ACIDOS, DE FORMULA (I). COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA R4SO2Y, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LAS QUE A, B, C Y D REPRESENTAN NITROGENO, METINO O METINO SUSTITUIDO, Y R1, R2, R3, R''1, R''2, Y R''3 PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN ACEPTOR DE ACIDOS, A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y 100JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANTITROMBOTICOS Y CARDIOVASCULARES Y SUS EFECTOS CARDIOTONICOS Y SOBRE LA PRESION SANGUINEA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843446778 DE3446778A1 (de) | 1984-12-21 | 1984-12-21 | Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES556974A0 ES556974A0 (es) | 1988-01-01 |
| ES8801276A1 true ES8801276A1 (es) | 1988-01-01 |
Family
ID=6253488
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES550241A Expired ES8703472A1 (es) | 1984-12-21 | 1985-12-20 | Procedimiento para preparar nuevos derivados imidazo |
| ES556974A Expired ES8801276A1 (es) | 1984-12-21 | 1986-07-23 | Procedimiento para preparar nuevos derivados imidazo |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES550241A Expired ES8703472A1 (es) | 1984-12-21 | 1985-12-20 | Procedimiento para preparar nuevos derivados imidazo |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4716169A (es) |
| EP (1) | EP0185345A1 (es) |
| JP (1) | JPS61152681A (es) |
| AU (1) | AU5154585A (es) |
| DD (1) | DD242407A5 (es) |
| DE (1) | DE3446778A1 (es) |
| DK (1) | DK590185A (es) |
| ES (2) | ES8703472A1 (es) |
| FI (1) | FI855080A7 (es) |
| GR (1) | GR853124B (es) |
| HU (1) | HU194562B (es) |
| NO (1) | NO855196L (es) |
| PT (1) | PT81716B (es) |
| ZA (1) | ZA859729B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4833149A (en) * | 1986-09-22 | 1989-05-23 | Ortho Pharmaceutical Corporation | 2- or 3-aryl substituted imidazo[1,2-a]pyridines |
| GB8719368D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Heterocyclic compounds |
| SE8704248D0 (sv) * | 1987-10-30 | 1987-10-30 | Haessle Ab | Medical use |
| ES2069137T3 (es) * | 1990-07-30 | 1995-05-01 | Takeda Chemical Industries Ltd | Derivados de imidazopiridina y su uso. |
| US6127576A (en) * | 1996-12-20 | 2000-10-03 | American Cyanamid Company | Aminophenyl ketone derivatives and a method for the preparation thereof |
| JP4327915B2 (ja) * | 1998-03-30 | 2009-09-09 | 株式会社デ・ウエスタン・セラピテクス研究所 | スルフォンアミド誘導体 |
| US6596731B2 (en) | 2001-03-27 | 2003-07-22 | Hoffmann-La Roche Inc. | Substituted imidazo[1,2-A] pyridine derivatives |
| WO2007033080A2 (en) * | 2005-09-12 | 2007-03-22 | Emory University | Alzheimer's disease imaging agents |
| US7723336B2 (en) * | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| EP2021340B1 (en) * | 2006-04-21 | 2014-07-23 | The Government Of The United States, As Represented by The Secretary Of Health And Human Services | Beta-amyloid pet imaging agents |
| EP1964841A1 (en) * | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]azine and their use as pharmaceuticals |
| EP1964840A1 (en) * | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]pyridines and their use as pharmaceuticals |
| US7868001B2 (en) | 2007-11-02 | 2011-01-11 | Hutchison Medipharma Enterprises Limited | Cytokine inhibitors |
| EP2240488B1 (en) * | 2008-02-06 | 2016-11-02 | Bristol-Myers Squibb Company | Substituted imidazopyridazines useful as kinase inhibitors |
| MX2010012429A (es) * | 2008-05-14 | 2010-12-21 | Otsuka Pharma Co Ltd | Composiciones que activan lipoproteina lipasa que comprenden derivados de benceno. |
| SMT201700457T1 (it) | 2012-04-26 | 2017-11-15 | Bristol Myers Squibb Co | DERlVATI IMIDAZOTIADIAZOLICI E IMIDAZOPIRAZINICI COME INIBITORI DEL RECETTORE ATTIVATO DA PROTEASI 4 (PAR4) PER IL TRATTAMENTO DELL'AGGREGAZIONE PIASTRINICA |
| EA201491967A1 (ru) | 2012-04-26 | 2015-03-31 | Бристол-Майерс Сквибб Компани | Производные имидазотиадиазола в качестве ингибиторов активируемых протеазой рецепторов 4 (par4) для лечения агрегации тромбоцитов |
| EP2855489B1 (en) * | 2012-04-26 | 2017-01-04 | Bristol-Myers Squibb Company | Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| US9617279B1 (en) | 2014-06-24 | 2017-04-11 | Bristol-Myers Squibb Company | Imidazooxadiazole compounds |
| US9598419B1 (en) | 2014-06-24 | 2017-03-21 | Universite De Montreal | Imidazotriazine and imidazodiazine compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS523957B2 (es) * | 1974-03-14 | 1977-01-31 | ||
| US4166851A (en) * | 1977-05-16 | 1979-09-04 | Merck & Co., Inc. | Certain imidazo(1,2a)pyridine derivatives |
| ZA839398B (en) * | 1982-12-27 | 1985-08-28 | Lilly Co Eli | Substituted imidazopyrimidines-pyrazines,and-triazines |
-
1984
- 1984-12-21 DE DE19843446778 patent/DE3446778A1/de not_active Withdrawn
-
1985
- 1985-12-16 EP EP85116025A patent/EP0185345A1/de not_active Withdrawn
- 1985-12-17 US US06/810,008 patent/US4716169A/en not_active Expired - Fee Related
- 1985-12-17 DD DD85284542A patent/DD242407A5/de unknown
- 1985-12-18 DK DK590185A patent/DK590185A/da not_active Application Discontinuation
- 1985-12-19 FI FI855080A patent/FI855080A7/fi not_active Application Discontinuation
- 1985-12-19 PT PT81716A patent/PT81716B/pt unknown
- 1985-12-20 JP JP60287602A patent/JPS61152681A/ja active Pending
- 1985-12-20 AU AU51545/85A patent/AU5154585A/en not_active Abandoned
- 1985-12-20 ES ES550241A patent/ES8703472A1/es not_active Expired
- 1985-12-20 GR GR853124A patent/GR853124B/el unknown
- 1985-12-20 NO NO855196A patent/NO855196L/no unknown
- 1985-12-20 HU HU854933A patent/HU194562B/hu unknown
- 1985-12-20 ZA ZA859729A patent/ZA859729B/xx unknown
-
1986
- 1986-07-23 ES ES556974A patent/ES8801276A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| HU194562B (en) | 1988-02-29 |
| FI855080A0 (fi) | 1985-12-19 |
| EP0185345A1 (de) | 1986-06-25 |
| PT81716B (de) | 1987-10-15 |
| ES8703472A1 (es) | 1987-02-16 |
| DE3446778A1 (de) | 1986-07-03 |
| PT81716A (de) | 1986-01-01 |
| FI855080A7 (fi) | 1986-06-22 |
| GR853124B (es) | 1986-04-22 |
| NO855196L (no) | 1986-06-23 |
| ES556974A0 (es) | 1988-01-01 |
| US4716169A (en) | 1987-12-29 |
| JPS61152681A (ja) | 1986-07-11 |
| AU5154585A (en) | 1986-06-26 |
| ZA859729B (en) | 1987-08-26 |
| HUT40434A (en) | 1986-12-28 |
| ES550241A0 (es) | 1987-02-16 |
| DK590185A (da) | 1986-06-22 |
| DK590185D0 (da) | 1985-12-18 |
| DD242407A5 (de) | 1987-01-28 |
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