ES8801791A1 - Un procedimiento para la preparacion de dihidrapiridinas utiles como agentes antisquemicos y anti-hipertensores. - Google Patents

Un procedimiento para la preparacion de dihidrapiridinas utiles como agentes antisquemicos y anti-hipertensores.

Info

Publication number
ES8801791A1
ES8801791A1 ES551012A ES551012A ES8801791A1 ES 8801791 A1 ES8801791 A1 ES 8801791A1 ES 551012 A ES551012 A ES 551012A ES 551012 A ES551012 A ES 551012A ES 8801791 A1 ES8801791 A1 ES 8801791A1
Authority
ES
Spain
Prior art keywords
het
alkyl
useful
hypertensive agents
dihydrapyridines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551012A
Other languages
English (en)
Other versions
ES551012A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of ES551012A0 publication Critical patent/ES551012A0/es
Publication of ES8801791A1 publication Critical patent/ES8801791A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DIHIDROPIRIDINAS, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R ES ARILO O HETEROARILO; R1 Y R2 SON CADA UNO DE ELLOS INDEPENDIENTEMENTE ALQUILO O 2-METOXIETILO; R5 ES HIDROGENO, ALQUILO O FENILO, CON UN COMPUESTO DE FORMULA GENERAL (III), EN LA QUE R4 ES UN RADICAL O ALQUILO C1-4; Y HAL ES UN ATOMODE HALOGENO, EN PRESENCIA DE UN DISOLVENTE PROTICO Y DE UNA BASE DEBIL PARA OBTENER EL DERIVADO N-SUSTITUIDO O EN PRESENCIA DE UN DISOLVENTE APROTICO PARA OBTENER EL DERIVADO O-SUSTITUIDO. DE APLICACION COMO AGENTES ANTI-ISQUEMICOS Y ANTI-HIPERTENSORES.
ES551012A 1985-01-19 1986-01-17 Un procedimiento para la preparacion de dihidrapiridinas utiles como agentes antisquemicos y anti-hipertensores. Expired ES8801791A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858501395A GB8501395D0 (en) 1985-01-19 1985-01-19 Dihydropyridine anti-ischaemic & anti-hypertensive agents

Publications (2)

Publication Number Publication Date
ES551012A0 ES551012A0 (es) 1988-02-16
ES8801791A1 true ES8801791A1 (es) 1988-02-16

Family

ID=10573115

Family Applications (1)

Application Number Title Priority Date Filing Date
ES551012A Expired ES8801791A1 (es) 1985-01-19 1986-01-17 Un procedimiento para la preparacion de dihidrapiridinas utiles como agentes antisquemicos y anti-hipertensores.

Country Status (12)

Country Link
EP (1) EP0189254A1 (es)
JP (1) JPS61167683A (es)
AU (1) AU565318B2 (es)
DK (1) DK22286A (es)
ES (1) ES8801791A1 (es)
FI (1) FI860224A7 (es)
GB (1) GB8501395D0 (es)
GR (1) GR860106B (es)
HU (1) HUT40109A (es)
IE (1) IE860147L (es)
PL (1) PL257530A1 (es)
PT (1) PT81862B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0315103A (pt) * 2002-10-07 2005-08-16 Artesian Therapeutics Inc Compostos de diidropiridina tendo capacidade simultânea de bloquear os canais de cálcio do tipo l e inibir a atividade da fosfodiesterase do tipo 3

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents

Also Published As

Publication number Publication date
IE860147L (en) 1986-07-19
HUT40109A (en) 1986-11-28
ES551012A0 (es) 1988-02-16
EP0189254A1 (en) 1986-07-30
DK22286A (da) 1986-07-20
AU5244886A (en) 1986-07-24
FI860224A0 (fi) 1986-01-17
FI860224A7 (fi) 1986-07-20
PT81862A (en) 1986-02-01
DK22286D0 (da) 1986-01-17
GR860106B (en) 1986-05-19
PL257530A1 (en) 1987-03-09
PT81862B (en) 1987-11-10
AU565318B2 (en) 1987-09-10
JPS61167683A (ja) 1986-07-29
GB8501395D0 (en) 1985-02-20

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