ES8900123A1 - Procedimiento para preparar pirrolo-bencimidazoles. - Google Patents

Procedimiento para preparar pirrolo-bencimidazoles.

Info

Publication number
ES8900123A1
ES8900123A1 ES557777A ES557777A ES8900123A1 ES 8900123 A1 ES8900123 A1 ES 8900123A1 ES 557777 A ES557777 A ES 557777A ES 557777 A ES557777 A ES 557777A ES 8900123 A1 ES8900123 A1 ES 8900123A1
Authority
ES
Spain
Prior art keywords
alkyl
alkenyl
hydroxyl
amino
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557777A
Other languages
English (en)
Other versions
ES557777A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES557777A0 publication Critical patent/ES557777A0/es
Publication of ES8900123A1 publication Critical patent/ES8900123A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Indole Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

SE HACE REACCIONAR COMPUESTO DE FRUL(I) DONDE R1 ES ATOMO DE HIDROGENO, GRUPO ALQUILO, ALQUENILO O CICLOALQUILO; R2 ES HIDROGENO, ALQUILO, ALQUENILO O CIANO, GRUPO CARBONILO SUSTITUIDO O CICLOALQUILENO, O R1 Y R2 FORMAN EN COMUN GRUPO ALQUILIDENO O CICLOALQUILENO; T ES OXIGENO AZUFRE CON UN COMPUESTO DE FORMULA (II) DONDE HET ES ANILLO HETEROCICLICO DE 6 MIEMBROS CON UN ATOMO DE OXIGENO O AZUFRE, ANILLO HETEROCICLICO DE 5 MIEMBROS CON 1-4 HETEROATOMOS O UN ANILLO HETEROCICLICO DE 6 MIEMBROS CON 2-5 HETEROATOMOS; X ES LINEA DE VALENCIA, GRUPO ALQUILENO C1-C4 O GRUPO VINILENO; Y ES ATOMO DE HALOGENO, GRUPO ESTER O GRUPO ANHIDRO. S CICLA EL COMPUESTO OBTENIDO, SI (II) ES ALDEHIDO SE CALIENTA LA CARGA DE REACCION A REFLUJO EN PRESENCIA DE OXIGENO Y DE CANTIDADES CATALITICAS DE ACIDO, SI (II) ES DENTADO DE CARBOXILICO SE HACE SIN DISOLVENTE O EN MEZCLA DE ESTOS A TEMPERATURA DE EBULLICION DE LA MEZCLA REACCION (0-250GC) EN PRESENCIA DE AGENTE DE CONDENSACION Y SE OBTIENE EL COMPUESTO (III) CON PROPIEDADES FARMACOLOGICAS COMO AUMENTAR LA FUERZA DEL CORAZON, DISMINUIR LA PRESION SANGUINEA, INFLUIR SOBRE LA FUNCION DE TROMBOCITOS Y MEJORAR LA MICROCIRCULACION. *FORMULA*
ES557777A 1985-01-18 1987-12-09 Procedimiento para preparar pirrolo-bencimidazoles. Expired ES8900123A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853501497 DE3501497A1 (de) 1985-01-18 1985-01-18 Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte

Publications (2)

Publication Number Publication Date
ES557777A0 ES557777A0 (es) 1989-01-16
ES8900123A1 true ES8900123A1 (es) 1989-01-16

Family

ID=6260116

Family Applications (2)

Application Number Title Priority Date Filing Date
ES551002A Expired ES8801832A1 (es) 1985-01-18 1986-01-17 Procedimiento para preparar pirrolo-bencimidazoles
ES557777A Expired ES8900123A1 (es) 1985-01-18 1987-12-09 Procedimiento para preparar pirrolo-bencimidazoles.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES551002A Expired ES8801832A1 (es) 1985-01-18 1986-01-17 Procedimiento para preparar pirrolo-bencimidazoles

Country Status (15)

Country Link
US (1) US4695567A (es)
EP (1) EP0189103B1 (es)
JP (1) JPS61167689A (es)
AT (1) ATE59649T1 (es)
AU (1) AU580832B2 (es)
DD (1) DD253620A5 (es)
DE (2) DE3501497A1 (es)
DK (1) DK20786A (es)
ES (2) ES8801832A1 (es)
FI (1) FI81579C (es)
GR (1) GR860144B (es)
HU (1) HU194242B (es)
IL (1) IL77582A (es)
SU (1) SU1470191A3 (es)
ZA (1) ZA86360B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3626664A1 (de) * 1986-08-07 1988-02-11 Boehringer Mannheim Gmbh Tricyclische benzotriazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3639466A1 (de) * 1986-11-18 1988-05-19 Thomae Gmbh Dr K Neue pyrrolo-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3642315A1 (de) * 1986-12-11 1988-06-23 Boehringer Mannheim Gmbh Neue pyrrolobenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3701277A1 (de) * 1987-01-17 1988-07-28 Boehringer Mannheim Gmbh Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel
DE3706427A1 (de) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
DE3740985A1 (de) * 1987-12-03 1989-06-15 Boehringer Mannheim Gmbh Verwendung linear anellierter tricyclen als hemmer der erythrozytenaggregation
ATE138658T1 (de) * 1987-12-30 1996-06-15 Orion Yhtymae Oy Heterocyclische verbindungen
US4963677A (en) * 1987-12-30 1990-10-16 Orion Corporation Ltd. Heterocyclic lactam compounds
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
DE3809868A1 (de) * 1988-03-24 1989-10-05 Boehringer Mannheim Gmbh Neue heterocyclisch substituierte 5,7-dihydro-pyrrolo(3,2-f)benzoxazol-6-one, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
TW200626149A (en) * 2004-09-24 2006-08-01 Hoffmann La Roche Tricycles, their manufacture and use as pharmaceutical agents
US7285569B2 (en) 2004-09-24 2007-10-23 Hoff Hoffmann-La Roche Inc. Tricycles, their manufacture and use as pharmaceutical agents
US20060142247A1 (en) * 2004-12-17 2006-06-29 Guy Georges Tricyclic heterocycles
JP2008533181A (ja) * 2005-04-14 2008-08-21 エフ．ホフマン−ラ ロシュ アーゲー 三環式アゾール誘導体、それらの製造及び医薬品としての使用
US7462639B2 (en) * 2005-04-14 2008-12-09 Hoffmann-La Roche Inc. Aminopyrazole derivatives
US20090143375A1 (en) * 2005-12-15 2009-06-04 F. Hoffmann-La Roche Ag Tricyclic Lactam Derivatives, Their Manufacture and Use as Pharmaceutical Agents
MX2008011860A (es) * 2006-03-23 2008-09-30 Hoffmann La Roche Derivados de indazol substituidos, su manufactura y uso como agentes farmaceuticos.
CN104619701B (zh) 2012-09-13 2016-10-19 霍夫曼-拉罗奇有限公司 用于治疗cns疾病的2-氧代-2，3-二氢-吲哚类化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN148930B (es) * 1977-09-19 1981-07-25 Hoffmann La Roche
EP0033612B1 (en) * 1980-02-02 1984-04-11 Beecham Group Plc Pyrano derivatives, a process for their preparation and antihypertensive compositions containing them
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
US4548946A (en) * 1981-03-26 1985-10-22 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 1,8-Dihydro-(or 3,8-dihydro)-8-aryl-2-[(substituted)thio]-indeno[1,2-d]imidazoles and their corresponding sulfoxides and sulfones
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
DE3410168A1 (de) * 1984-03-20 1985-09-26 Boehringer Mannheim Gmbh, 6800 Mannheim Neue isochinolin-dione, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
PL147842B1 (en) * 1984-05-12 1989-08-31 Method of obtaining novel pyroisobenzimidazoles
US4552876A (en) * 1984-07-09 1985-11-12 Usv Pharmaceutical Corp. Bisbenzoxazines and pharmaceutical use
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
SU1470191A3 (ru) 1989-03-30
DK20786D0 (da) 1986-01-16
FI81579C (fi) 1990-11-12
ES557777A0 (es) 1989-01-16
HUT41791A (en) 1987-05-28
HU194242B (en) 1988-01-28
JPS61167689A (ja) 1986-07-29
EP0189103A3 (en) 1987-12-23
US4695567A (en) 1987-09-22
DK20786A (da) 1986-07-19
ZA86360B (en) 1986-09-24
DE3501497A1 (de) 1986-07-24
FI81579B (fi) 1990-07-31
IL77582A (en) 1990-01-18
ES551002A0 (es) 1988-03-01
EP0189103A2 (de) 1986-07-30
GR860144B (en) 1986-05-16
DE3676313D1 (de) 1991-02-07
EP0189103B1 (de) 1991-01-02
FI860228A7 (fi) 1986-07-19
ATE59649T1 (de) 1991-01-15
AU580832B2 (en) 1989-02-02
AU5224586A (en) 1986-07-24
ES8801832A1 (es) 1988-03-01
FI860228A0 (fi) 1986-01-17
DD253620A5 (de) 1988-01-27

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960401