FI105206B - Ilmentämisjärjestelmä - Google Patents

Ilmentämisjärjestelmä Download PDF

Info

Publication number: FI105206B
Authority: FI; Finland
Prior art keywords: dna; dsm; gene; fragment; lambda
Prior art date: 1989-09-02

Application number

FI904299A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI904299A0 (fi

Inventor

Frank Buxton

Graaff Leendert Hendrik De

Jacob Visser

Hendrik Jan Dirk Bussink

Hermanus Cornelis Maria Kester

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-02

Filing date

1990-08-31

Publication date

2000-06-30

1989-09-02 Priority claimed from GB898919884A external-priority patent/GB8919884D0/en

1990-08-31 Application filed by Novartis Ag filed Critical Novartis Ag

1990-08-31 Publication of FI904299A0 publication Critical patent/FI904299A0/fi

2000-06-30 Application granted granted Critical

2000-06-30 Publication of FI105206B publication Critical patent/FI105206B/fi

Links

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DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/10—Marmalades; Jams; Jellies; Other similar fruit or vegetable compositions; Simulated fruit products
- A23L21/11—Marmalades; Jams; Jellies; Other similar fruit or vegetable compositions; Simulated fruit products obtained by enzymatic digestion of fruit or vegetable compositions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01015—Polygalacturonase (3.2.1.15)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Nutrition Science (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Mycology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

FI904299A 1989-09-02 1990-08-31 Ilmentämisjärjestelmä FI105206B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB898919884A GB8919884D0 (en)	1989-09-02	1989-09-02	Fungal expression system
GB8919884		1989-09-02
GB909013616A GB9013616D0 (en)	1989-09-02	1990-06-19	Fungal expression system
GB9013616		1990-06-19

Publications (2)

Publication Number	Publication Date
FI904299A0 FI904299A0 (fi)	1990-08-31
FI105206B true FI105206B (fi)	2000-06-30

Family

ID=26295856

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI904299A FI105206B (fi)	1989-09-02	1990-08-31	Ilmentämisjärjestelmä

Country Status (11)

Country	Link
EP (1)	EP0421919A3 (fr)
JP (1)	JP3576549B2 (fr)
AU (1)	AU640405B2 (fr)
CA (1)	CA2024487C (fr)
FI (1)	FI105206B (fr)
HU (1)	HU220337B (fr)
IE (1)	IE903180A1 (fr)
IL (1)	IL95553A (fr)
NO (1)	NO316388B1 (fr)
NZ (1)	NZ235115A (fr)
PT (1)	PT95171B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5863783A (en) *	1991-03-27	1999-01-26	Gist-Brocades, N.V.	Cloning and expression of DNA molecules encoding arabinan-degrading enzymes of fungal origin
AU664223B2 (en) *	1991-12-09	1995-11-09	Unilever Plc	Process for producing/secreting a protein by a transformed mould using expression/secretion regulating regions derived from an (aspergillus) endoxylanase II gene
AU5809594A (en) *	1992-12-23	1994-07-19	Novo Nordisk A/S	An enzyme with polygalacturonase activity
JPH07503861A (ja) *	1992-12-24	1995-04-27	ギスト　ブロカデス　ナムローゼ　フェンノートシャップ	アスペルギルスからのエキソ−ポリガラクツロナーゼ遺伝子のクローニングと発現
US5674728A (en) *	1993-11-03	1997-10-07	Novartis Corporation	Aspergillus niger vacuolar aspartyl protease
AU2724799A (en) *	1998-02-10	1999-08-30	Dsm N.V.	Novel endo-xylogalacturonase
WO2000017367A1 (fr)	1998-09-18	2000-03-30	Dsm N.V.	Aspergillus tubigensis polygalacturonase
BR0009184A (pt)	1999-03-22	2001-12-26	Novozymes As	Processo para degradação ou modificação defibras, de fio ou de pano tecido ou não-tecidocompreendendo material de planta, composição delimpeza ou de lavagem de roupa, e, processo para alimpeza de uma superfìcie dura
CN102292437B (zh)	2008-12-19	2015-06-24	杜邦营养生物科学有限公司	生产酶产品的方法
EP4407039A4 (fr) *	2021-09-22	2026-03-11	Kao Corp	Procédé de production d'enzyme de saccharification

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8626879D0 (en) *	1986-11-11	1986-12-10	Ici Plc	Dna
GB8702475D0 (en) *	1987-02-04	1987-03-11	Ciba Geigy Ag	Expression system
DE3908813A1 (de) *	1989-03-17	1990-09-20	Roehm Gmbh	Verfahren zur expression eines aus aspergillus niger stammenden gens in einem aspergillus

1990
- 1990-08-24 EP EP19900810643 patent/EP0421919A3/en not_active Ceased
- 1990-08-31 PT PT95171A patent/PT95171B/pt not_active IP Right Cessation
- 1990-08-31 NZ NZ235115A patent/NZ235115A/xx unknown
- 1990-08-31 IL IL9555390A patent/IL95553A/en active IP Right Grant
- 1990-08-31 NO NO19903812A patent/NO316388B1/no not_active IP Right Cessation
- 1990-08-31 FI FI904299A patent/FI105206B/fi active IP Right Grant
- 1990-08-31 IE IE318090A patent/IE903180A1/en unknown
- 1990-08-31 CA CA002024487A patent/CA2024487C/fr not_active Expired - Lifetime
- 1990-08-31 HU HU726/90A patent/HU220337B/hu unknown
- 1990-08-31 JP JP22848590A patent/JP3576549B2/ja not_active Expired - Lifetime
- 1990-08-31 AU AU62054/90A patent/AU640405B2/en not_active Expired

Also Published As

Publication number	Publication date
AU640405B2 (en)	1993-08-26
NO903812L (no)	1991-03-04
EP0421919A2 (fr)	1991-04-10
HU220337B (hu)	2001-12-28
PT95171B (pt)	1997-09-30
AU6205490A (en)	1991-03-07
IL95553A (en)	2005-12-18
CA2024487A1 (fr)	1991-03-03
FI904299A0 (fi)	1990-08-31
NO316388B1 (no)	2004-01-19
CA2024487C (fr)	2008-04-29
EP0421919A3 (en)	1992-04-15
IL95553A0 (en)	1991-06-30
NZ235115A (en)	1991-09-25
NO903812D0 (no)	1990-08-31
IE903180A1 (en)	1991-03-13
JP3576549B2 (ja)	2004-10-13
JPH03224489A (ja)	1991-10-03
PT95171A (pt)	1991-06-25
HUT54735A (en)	1991-03-28

Legal Events

Date	Code	Title	Description
1997-08-08	GB	Transfer or assigment of application	Owner name: NOVARTIS AG
2004-08-31	FG	Patent granted	Owner name: NOVARTIS AG

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