FI108514B - Polymeerimembraanien käyttö sellaisten farmaseuttisten liuosten jakelussa, jotka sisältävät kvaternäärisiä ammoniumyhdisteitä - Google Patents

Polymeerimembraanien käyttö sellaisten farmaseuttisten liuosten jakelussa, jotka sisältävät kvaternäärisiä ammoniumyhdisteitä Download PDF

Info

Publication number: FI108514B
Authority: FI; Finland
Prior art keywords: membrane; use according; container; quaternary ammonium; pharmaceutical
Prior art date: 1993-06-25

Application number

FI943066A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI943066A0 (fi

FI943066A7 (fi

Inventor

Mas Alberto Vallet

Guasch Francesc Xavier Gimenez

Original Assignee

Cusi Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-25

Filing date

1994-06-23

Publication date

2002-02-15

1993-06-25 Priority claimed from ES9301443A external-priority patent/ES2064286B1/es

1994-06-23 Application filed by Cusi Lab filed Critical Cusi Lab

1994-06-23 Publication of FI943066A0 publication Critical patent/FI943066A0/fi

1994-12-26 Publication of FI943066A7 publication Critical patent/FI943066A7/fi

2002-02-15 Application granted granted Critical

2002-02-15 Publication of FI108514B publication Critical patent/FI108514B/fi

Links

239000003755 preservative agent Substances 0.000 title claims abstract description 20
239000003186 pharmaceutical solution Substances 0.000 title claims description 20
150000003856 quaternary ammonium compounds Chemical class 0.000 title claims description 17
238000009826 distribution Methods 0.000 title claims description 7
229920005597 polymer membrane Polymers 0.000 title claims 9
239000012528 membrane Substances 0.000 claims abstract description 74
230000014759 maintenance of location Effects 0.000 claims abstract description 20
230000002335 preservative effect Effects 0.000 claims abstract description 17
239000002033 PVDF binder Substances 0.000 claims description 10
229920002981 polyvinylidene fluoride Polymers 0.000 claims description 10
229920002492 poly(sulfone) Polymers 0.000 claims description 3
229920002284 Cellulose triacetate Polymers 0.000 claims description 2
239000000020 Nitrocellulose Substances 0.000 claims description 2
239000004952 Polyamide Substances 0.000 claims description 2
NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims description 2
FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims description 2
229920001220 nitrocellulos Polymers 0.000 claims description 2
229920002647 polyamide Polymers 0.000 claims description 2
229920000515 polycarbonate Polymers 0.000 claims description 2
239000004417 polycarbonate Substances 0.000 claims description 2
229920001296 polysiloxane Polymers 0.000 claims description 2
239000004627 regenerated cellulose Substances 0.000 claims description 2
229910021529 ammonia Inorganic materials 0.000 claims 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 1
125000001453 quaternary ammonium group Chemical group 0.000 claims 1
238000011458 pharmacological treatment Methods 0.000 abstract 1
239000000243 solution Substances 0.000 description 24
210000003128 head Anatomy 0.000 description 22
229960000686 benzalkonium chloride Drugs 0.000 description 13
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 13
229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 11
238000003860 storage Methods 0.000 description 11
239000004480 active ingredient Substances 0.000 description 9
239000011148 porous material Substances 0.000 description 9
230000000694 effects Effects 0.000 description 7
239000007788 liquid Substances 0.000 description 7
239000000463 material Substances 0.000 description 7
238000005192 partition Methods 0.000 description 7
238000007789 sealing Methods 0.000 description 7
238000011109 contamination Methods 0.000 description 4
238000001914 filtration Methods 0.000 description 4
238000009472 formulation Methods 0.000 description 4
238000000034 method Methods 0.000 description 4
239000000203 mixture Substances 0.000 description 4
238000011282 treatment Methods 0.000 description 4
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 3
230000008602 contraction Effects 0.000 description 3
239000012530 fluid Substances 0.000 description 3
150000004820 halides Chemical class 0.000 description 3
239000012535 impurity Substances 0.000 description 3
230000000670 limiting effect Effects 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
239000007787 solid Substances 0.000 description 3
239000000126 substance Substances 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
230000004075 alteration Effects 0.000 description 2
230000000844 anti-bacterial effect Effects 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 description 2
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
244000005700 microbiome Species 0.000 description 2
239000008194 pharmaceutical composition Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 description 1
LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
230000009471 action Effects 0.000 description 1
125000002947 alkylene group Chemical group 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
229960003872 benzethonium Drugs 0.000 description 1
235000014121 butter Nutrition 0.000 description 1
229960002165 carteolol hydrochloride Drugs 0.000 description 1
FYBXRCFPOTXTJF-UHFFFAOYSA-N carteolol hydrochloride Chemical compound [Cl-].N1C(=O)CCC2=C1C=CC=C2OCC(O)C[NH2+]C(C)(C)C FYBXRCFPOTXTJF-UHFFFAOYSA-N 0.000 description 1
239000003093 cationic surfactant Substances 0.000 description 1
QDYLMAYUEZBUFO-UHFFFAOYSA-N cetalkonium chloride Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 QDYLMAYUEZBUFO-UHFFFAOYSA-N 0.000 description 1
229960000228 cetalkonium chloride Drugs 0.000 description 1
229960002798 cetrimide Drugs 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
210000004087 cornea Anatomy 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
SIYLLGKDQZGJHK-UHFFFAOYSA-N dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium Chemical compound C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 SIYLLGKDQZGJHK-UHFFFAOYSA-N 0.000 description 1
238000006073 displacement reaction Methods 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000007831 electrophysiology Effects 0.000 description 1
238000002001 electrophysiology Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
244000000010 microbial pathogen Species 0.000 description 1
239000002997 ophthalmic solution Substances 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
238000003825 pressing Methods 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000037390 scarring Effects 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
230000007480 spreading Effects 0.000 description 1
238000003892 spreading Methods 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
- A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
- A61J1/1456—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Closures For Containers (AREA)
Separation Using Semi-Permeable Membranes (AREA)
Compositions Of Macromolecular Compounds (AREA)
Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Manufacture Of Macromolecular Shaped Articles (AREA)

FI943066A 1993-06-25 1994-06-23 Polymeerimembraanien käyttö sellaisten farmaseuttisten liuosten jakelussa, jotka sisältävät kvaternäärisiä ammoniumyhdisteitä FI108514B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
ES9301443		1993-06-25
ES9301443A ES2064286B1 (es)	1993-06-25	1993-06-25	Nueva aplicacion de membranas polimericas en la dispensacion de soluciones farmaceuticas que contienen compuestos de amonio cuaternario como conservadores y envase dosificador correspondiente.
ES9401260		1994-06-09
ES9401260A ES2119588B1 (es)	1993-06-25	1994-06-09	Mejoras introducidas en la patente de invencion n-p 9301443/0, por: nueva aplicacion de membranas polimericas en la dispensacion de soluciones farmaceuticas que contienen compuestos de amonio cuaternario como conservadores, y envase dosificador correspondiente.

Publications (3)

Publication Number	Publication Date
FI943066A0 FI943066A0 (fi)	1994-06-23
FI943066A7 FI943066A7 (fi)	1994-12-26
FI108514B true FI108514B (fi)	2002-02-15

Family

ID=26154731

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI943066A FI108514B (fi)	1993-06-25	1994-06-23	Polymeerimembraanien käyttö sellaisten farmaseuttisten liuosten jakelussa, jotka sisältävät kvaternäärisiä ammoniumyhdisteitä

Country Status (9)

Country	Link
US (1)	US5588559A (fr)
EP (1)	EP0631770B1 (fr)
JP (1)	JP2736227B2 (fr)
CN (1)	CN1105230A (fr)
AT (1)	ATE168553T1 (fr)
AU (1)	AU671743B2 (fr)
CA (1)	CA2126703C (fr)
DE (1)	DE69411816T2 (fr)
FI (1)	FI108514B (fr)

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DE602004017477D1 (de) *	2004-11-09	2008-12-11	Novagali Pharma Sa	Öl-in-Wasser-Emulsion mit niedriger Konzentration des kationischen Mittels und positivem Zetapotential
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EP2228058A1 (fr)	2009-03-04	2010-09-15	Novagali Pharma S.A.	Émulsion anionique d'huile dans l'eau contenant des prostaglandines et leurs utilisations
EP2389939A1 (fr)	2010-05-28	2011-11-30	Novagali Pharma S.A.	Utilisation de prostaglandines F2alpha et analogues pour la cicatrisation des lésions de la cornée et du conjonctif
EP2361599A1 (fr) *	2010-02-22	2011-08-31	Fresenius Kabi Deutschland GmbH	Dispositif d'alimentation et d'extraction d'un liquide dans ou hors d'un récipient
FR2963329B1 (fr) *	2010-07-30	2013-06-28	Thea Lab	Tete de distribution d'un liquide goutte a goutte
US20120312840A1 (en) *	2011-05-13	2012-12-13	Ayako Hasegawa	Container closure system with integral antimicrobial additives
KR101554189B1 (ko) *	2013-12-10	2015-09-21	(주)연우	액상 내용물을 방울 형태로 배출시키는 튜브형 화장품 용기
USD770287S1 (en) *	2014-02-27	2016-11-01	Ivoclar Vivadent Ag	Bottle
USD733286S1 (en) *	2014-04-30	2015-06-30	Meadwestvaco Corporation	Pump with locking sleeve
JP6660939B2 (ja) *	2014-08-13	2020-03-11	ユニバーシティオブフロリダリサーチファンデーションインコーポレーティッド	点眼剤からの保存剤除去
CN104307584B (zh) *	2014-09-25	2015-09-16	瑞安市富日包装机械有限公司	滴管组合机
US11454570B2 (en) *	2016-02-29	2022-09-27	Distek, Inc.	Sample probe for dissolution testing and the like
JP7173969B2 (ja) *	2016-12-02	2022-11-16	ユニバーシティオブフロリダリサーチファンデーションインコーポレーティッド	点眼剤からの防腐剤除去
TW202005623A (zh) *	2018-04-06	2020-02-01	美商蒂克利爾公司	用於輸送治療劑之系統及方法
CN113891697B (zh)	2019-03-28	2025-03-18	特清公司	用于眼用制剂的流量控制的装置和方法
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CN110683173B (zh) *	2019-11-01	2024-08-23	安徽创孚医疗科技有限公司	一种除氧冻存装置
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1994
- 1994-06-23 EP EP19940201823 patent/EP0631770B1/fr not_active Expired - Lifetime
- 1994-06-23 AT AT94201823T patent/ATE168553T1/de not_active IP Right Cessation
- 1994-06-23 FI FI943066A patent/FI108514B/fi active
- 1994-06-23 DE DE69411816T patent/DE69411816T2/de not_active Expired - Fee Related
- 1994-06-24 US US08/265,409 patent/US5588559A/en not_active Expired - Lifetime
- 1994-06-24 CN CN94108914A patent/CN1105230A/zh active Pending
- 1994-06-24 CA CA 2126703 patent/CA2126703C/fr not_active Expired - Fee Related
- 1994-06-27 JP JP14473294A patent/JP2736227B2/ja not_active Expired - Fee Related
- 1994-06-27 AU AU66007/94A patent/AU671743B2/en not_active Ceased

Also Published As

Publication number	Publication date
US5588559A (en)	1996-12-31
FI943066A0 (fi)	1994-06-23
ATE168553T1 (de)	1998-08-15
CN1105230A (zh)	1995-07-19
JPH07171193A (ja)	1995-07-11
EP0631770B1 (fr)	1998-07-22
DE69411816T2 (de)	1998-12-03
FI943066A7 (fi)	1994-12-26
CA2126703A1 (fr)	1994-12-26
AU6600794A (en)	1995-01-05
CA2126703C (fr)	1999-08-17
DE69411816D1 (de)	1998-08-27
AU671743B2 (en)	1996-09-05
JP2736227B2 (ja)	1998-04-02
EP0631770A1 (fr)	1995-01-04

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