FI59678C - Diagnostiskt medel foer att paovisa aeggvita i kroppsvaetskor - Google Patents

Diagnostiskt medel foer att paovisa aeggvita i kroppsvaetskor Download PDF

Info

Publication number: FI59678C
Authority: FI; Finland
Prior art keywords: protein; diagnostic; acetic acid; indicator; solution
Prior art date: 1975-03-12

Application number

FI760578A

Other languages

English (en)

Finnish (fi)

Other versions

FI760578A7 (da

FI59678B (fi

Inventor

Walter Rittersdorf

Werner Guethlein

Wolfgang Werner

Hans-Georg Rey

Peter Rieckmann

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-03-12

Filing date

1976-03-05

Publication date

1981-09-10

1976-03-05 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1976-09-13 Publication of FI760578A7 publication Critical patent/FI760578A7/fi

1981-05-29 Application granted granted Critical

1981-05-29 Publication of FI59678B publication Critical patent/FI59678B/fi

1981-09-10 Publication of FI59678C publication Critical patent/FI59678C/fi

Links

QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 40
102000004169 proteins and genes Human genes 0.000 description 24
108090000623 proteins and genes Proteins 0.000 description 24
239000000243 solution Substances 0.000 description 21
LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 18
229960000583 acetic acid Drugs 0.000 description 17
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
229920001451 polypropylene glycol Polymers 0.000 description 15
210000002700 urine Anatomy 0.000 description 14
LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 11
239000012362 glacial acetic acid Substances 0.000 description 11
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
239000000872 buffer Substances 0.000 description 10
238000006243 chemical reaction Methods 0.000 description 10
235000001258 Cinchona calisaya Nutrition 0.000 description 9
239000000460 chlorine Substances 0.000 description 9
229960000948 quinine Drugs 0.000 description 9
102000009027 Albumins Human genes 0.000 description 8
108010088751 Albumins Proteins 0.000 description 8
150000001875 compounds Chemical class 0.000 description 8
239000000203 mixture Substances 0.000 description 8
238000003756 stirring Methods 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
239000002585 base Substances 0.000 description 5
229910052757 nitrogen Inorganic materials 0.000 description 5
239000004094 surface-active agent Substances 0.000 description 5
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
QPMIVFWZGPTDPN-UHFFFAOYSA-N Tetrabromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C(C(Br)=C(Br)C(Br)=C2Br)=C2S(=O)(=O)O1 QPMIVFWZGPTDPN-UHFFFAOYSA-N 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 4
210000001124 body fluid Anatomy 0.000 description 4
239000010839 body fluid Substances 0.000 description 4
239000013078 crystal Substances 0.000 description 4
239000004615 ingredient Substances 0.000 description 4
125000006353 oxyethylene group Chemical group 0.000 description 4
LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 description 4
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
239000003153 chemical reaction reagent Substances 0.000 description 3
229910052801 chlorine Inorganic materials 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
238000005470 impregnation Methods 0.000 description 3
230000002452 interceptive effect Effects 0.000 description 3
229920000151 polyglycol Polymers 0.000 description 3
239000010695 polyglycol Substances 0.000 description 3
230000035945 sensitivity Effects 0.000 description 3
239000002904 solvent Substances 0.000 description 3
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
ISPYQTSUDJAMAB-UHFFFAOYSA-N 2-chlorophenol Chemical compound OC1=CC=CC=C1Cl ISPYQTSUDJAMAB-UHFFFAOYSA-N 0.000 description 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 2
GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
239000002250 absorbent Substances 0.000 description 2
230000002745 absorbent Effects 0.000 description 2
239000002253 acid Substances 0.000 description 2
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
229910021529 ammonia Inorganic materials 0.000 description 2
239000003945 anionic surfactant Substances 0.000 description 2
125000004429 atom Chemical group 0.000 description 2
CNBGNNVCVSKAQZ-UHFFFAOYSA-N benzydamine Chemical compound C12=CC=CC=C2C(OCCCN(C)C)=NN1CC1=CC=CC=C1 CNBGNNVCVSKAQZ-UHFFFAOYSA-N 0.000 description 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
229910052794 bromium Inorganic materials 0.000 description 2
239000006172 buffering agent Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
238000005660 chlorination reaction Methods 0.000 description 2
230000007547 defect Effects 0.000 description 2
238000001514 detection method Methods 0.000 description 2
238000001035 drying Methods 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
239000001630 malic acid Substances 0.000 description 2
235000011090 malic acid Nutrition 0.000 description 2
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 2
239000007793 ph indicator Substances 0.000 description 2
229960001404 quinidine Drugs 0.000 description 2
238000001953 recrystallisation Methods 0.000 description 2
HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
238000010186 staining Methods 0.000 description 2
239000000725 suspension Substances 0.000 description 2
TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 description 1
AFCLDQRTFFTBAP-UHFFFAOYSA-N 2,3,4,5-tetrachloro-6-(2,3,4,5-tetrachloro-6-sulfobenzoyl)oxycarbonylbenzenesulfonic acid Chemical compound OS(=O)(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C(=O)OC(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1S(O)(=O)=O AFCLDQRTFFTBAP-UHFFFAOYSA-N 0.000 description 1
RULKYXXCCZZKDZ-UHFFFAOYSA-N 2,3,4,5-tetrachlorophenol Chemical compound OC1=CC(Cl)=C(Cl)C(Cl)=C1Cl RULKYXXCCZZKDZ-UHFFFAOYSA-N 0.000 description 1
QQGRFMIMXPWKPM-UHFFFAOYSA-N 2,3,4-tributylphenol Chemical compound CCCCC1=CC=C(O)C(CCCC)=C1CCCC QQGRFMIMXPWKPM-UHFFFAOYSA-N 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-L 2-(carboxymethyl)-2-hydroxysuccinate Chemical compound [O-]C(=O)CC(O)(C(=O)O)CC([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-L 0.000 description 1
VADKRMSMGWJZCF-UHFFFAOYSA-N 2-bromophenol Chemical compound OC1=CC=CC=C1Br VADKRMSMGWJZCF-UHFFFAOYSA-N 0.000 description 1
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
239000006173 Good's buffer Substances 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
239000002841 Lewis acid Substances 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
229910021626 Tin(II) chloride Inorganic materials 0.000 description 1
ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
108091061763 Triple-stranded DNA Proteins 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000000654 additive Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
239000003513 alkali Substances 0.000 description 1
150000001447 alkali salts Chemical class 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
150000008064 anhydrides Chemical class 0.000 description 1
239000010425 asbestos Substances 0.000 description 1
229960000333 benzydamine Drugs 0.000 description 1
230000031709 bromination Effects 0.000 description 1
238000005893 bromination reaction Methods 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000003093 cationic surfactant Substances 0.000 description 1
125000001309 chloro group Chemical group Cl* 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
229940096386 coconut alcohol Drugs 0.000 description 1
239000008139 complexing agent Substances 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
238000002845 discoloration Methods 0.000 description 1
239000002359 drug metabolite Substances 0.000 description 1
239000000975 dye Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
SQFXATUXPUCFFO-UHFFFAOYSA-N ethyl 2-[(3,5-dibromo-4-hydroxyphenyl)-(3,5-dibromo-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]benzoate Chemical compound CCOC(=O)C1=CC=CC=C1C(C=1C=C(Br)C(O)=C(Br)C=1)=C1C=C(Br)C(=O)C(Br)=C1 SQFXATUXPUCFFO-UHFFFAOYSA-N 0.000 description 1
125000004494 ethyl ester group Chemical group 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
239000012530 fluid Substances 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
238000007654 immersion Methods 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
229910052920 inorganic sulfate Inorganic materials 0.000 description 1
208000017169 kidney disease Diseases 0.000 description 1
150000007517 lewis acids Chemical class 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
238000000034 method Methods 0.000 description 1
125000000896 monocarboxylic acid group Chemical group 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
239000003921 oil Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
125000005702 oxyalkylene group Chemical group 0.000 description 1
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
150000002989 phenols Chemical class 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
-1 polypropylenes Polymers 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
238000002331 protein detection Methods 0.000 description 1
239000002994 raw material Substances 0.000 description 1
230000000979 retarding effect Effects 0.000 description 1
229910052895 riebeckite Inorganic materials 0.000 description 1
238000000926 separation method Methods 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000001119 stannous chloride Substances 0.000 description 1
235000011150 stannous chloride Nutrition 0.000 description 1
238000005728 strengthening Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
230000008961 swelling Effects 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
- C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6827—Total protein determination, e.g. albumin in urine
- G01N33/6839—Total protein determination, e.g. albumin in urine involving dyes, e.g. Coomassie blue, bromcresol green

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Hematology (AREA)
Cell Biology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Bioinformatics & Computational Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Microbiology (AREA)
Food Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

FI760578A 1975-03-12 1976-03-05 Diagnostiskt medel foer att paovisa aeggvita i kroppsvaetskor FI59678C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE2510633		1975-03-12
DE2510633A DE2510633C3 (de)	1975-03-12	1975-03-12	Diagnostisches Mittel zum Nachweis von Eiweiß in Körperflüssigkeiten und dafür geeignete Indikatorfarbstoffe

Publications (3)

Publication Number	Publication Date
FI760578A7 FI760578A7 (da)	1976-09-13
FI59678B FI59678B (fi)	1981-05-29
FI59678C true FI59678C (fi)	1981-09-10

Family

ID=5941061

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI760578A FI59678C (fi)	1975-03-12	1976-03-05	Diagnostiskt medel foer att paovisa aeggvita i kroppsvaetskor

Country Status (25)

Country	Link
US (2)	US4013416A (da)
JP (1)	JPS5278866A (da)
AT (1)	AT349153B (da)
AU (1)	AU501932B2 (da)
BE (1)	BE839363A (da)
CA (1)	CA1055824A (da)
CH (1)	CH627000A5 (da)
CS (1)	CS190526B2 (da)
DD (2)	DD125021A5 (da)
DE (1)	DE2510633C3 (da)
DK (1)	DK144443C (da)
ES (1)	ES445808A1 (da)
FI (1)	FI59678C (da)
FR (1)	FR2304084A1 (da)
GB (2)	GB1487717A (da)
HU (1)	HU172450B (da)
IE (3)	IE42507L (da)
IL (1)	IL49167A (da)
IT (1)	IT1056947B (da)
LU (1)	LU74519A1 (da)
NL (1)	NL164966C (da)
PL (1)	PL103510B1 (da)
SE (1)	SE423754B (da)
SU (2)	SU633501A3 (da)
YU (1)	YU59476A (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5513814A (en) *	1978-07-12	1980-01-31	Mitsui Toatsu Chem Inc	Inspecting method for albumin
US4654309A (en) *	1980-12-19	1987-03-31	Minnesota Mining And Manufacturing Co.	Test method and article for estimating the concentration of free acid in liquid
BR8108925A (pt) *	1980-12-19	1982-11-30	Minnesota Mining & Mfg	Processo de teste e artigo para estimar a concentracao de acido livre em liquido
US4542750A (en) *	1982-08-13	1985-09-24	Primary Diagnostic Systems, Inc.	Non-invasive method for diagnosing incipient or developed cancer tissue
US4568647A (en) *	1983-10-11	1986-02-04	Eastman Kodak Company	Method and element for albumin assay
DE3345748A1 (de) *	1983-12-17	1985-08-29	Boehringer Mannheim Gmbh, 6800 Mannheim	Phenolsulfonphthaleinyl-ss-d-galactoside, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der ss-d-galactosidase
US5183742A (en) *	1984-02-24	1993-02-02	Dai Nippon Insatsu Kabushiki Kaisha	Test device for detecting glucose, protein urobilinogen, and/or occult blood in body fluids and/or determining the PH thereof
EP0287745B1 (en) *	1987-04-22	1991-11-13	Schiapparelli Biosystems, Inc.	Method for the determination of albumin in biological fluids
CA1320420C (en) *	1988-03-25	1993-07-20	Dominique Thoraval	Paper chemical agent detectors
US5194390A (en) *	1988-07-05	1993-03-16	Miles Inc.	Composition for the assay of albumin
DE3823151C2 (de) *	1988-07-08	1997-07-10	Boehringer Mannheim Gmbh	Verfahren zur Bestimmung der Ionenstärke oder des spezifischen Gewichts von wäßrigen Flüssigkeiten
US5077222A (en) *	1988-09-30	1991-12-31	Miles Inc.	Method for assaying for proteins using a dual indicator reagent composition
US5049358A (en) *	1988-09-30	1991-09-17	Miles Inc.	Composition and test device for assaying for proteins
JPH0752198B2 (ja) *	1989-08-30	1995-06-05	マイルス・インコーポレーテッド	変色を示す組成物、アルブミンの存在及び／又は濃度の測定方法及び検出具
US5264589A (en) *	1991-06-06	1993-11-23	Miles Inc.	Merocyanine protein error indicators
US5187104A (en) *	1991-06-06	1993-02-16	Miles Inc.	Nitro or nitroso substituted polyhalogenated phenolsulfonephthaleins as protein indicators in biological samples
ES2092595T3 (es) *	1991-06-06	1996-12-01	Bayer Ag	Tira de ensayo que contiene merocianina y fenolsulfonoftaleinas polihalogenadas nitro o nitroso sustituidas como indicadores de proteinas.
US5326707A (en) *	1991-11-29	1994-07-05	Miles Inc.	Composition and device for urinary protein assay and method of using the same
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1975
- 1975-03-12 DE DE2510633A patent/DE2510633C3/de not_active Expired
1976
- 1976-02-23 SE SE7602134A patent/SE423754B/xx not_active IP Right Cessation
- 1976-02-26 US US05/661,687 patent/US4013416A/en not_active Expired - Lifetime
- 1976-02-26 DD DD191553A patent/DD125021A5/xx unknown
- 1976-02-26 DD DD7600198424A patent/DD129788A5/xx unknown
- 1976-03-05 IL IL49167A patent/IL49167A/xx unknown
- 1976-03-05 SU SU762328363A patent/SU633501A3/ru active
- 1976-03-05 FI FI760578A patent/FI59678C/fi not_active IP Right Cessation
- 1976-03-05 CS CS761458A patent/CS190526B2/cs unknown
- 1976-03-05 ES ES445808A patent/ES445808A1/es not_active Expired
- 1976-03-08 YU YU00594/76A patent/YU59476A/xx unknown
- 1976-03-08 IT IT20968/76A patent/IT1056947B/it active
- 1976-03-09 BE BE164993A patent/BE839363A/xx not_active IP Right Cessation
- 1976-03-09 NL NL7602442.A patent/NL164966C/xx not_active IP Right Cessation
- 1976-03-10 DK DK103276A patent/DK144443C/da not_active IP Right Cessation
- 1976-03-10 CH CH296376A patent/CH627000A5/de not_active IP Right Cessation
- 1976-03-10 HU HU76BO00001602A patent/HU172450B/hu unknown
- 1976-03-10 LU LU74519A patent/LU74519A1/xx unknown
- 1976-03-11 IE IE772561A patent/IE42507L/xx unknown
- 1976-03-11 GB GB9734/76A patent/GB1487717A/en not_active Expired
- 1976-03-11 GB GB27421/76A patent/GB1487718A/en not_active Expired
- 1976-03-11 AU AU11895/76A patent/AU501932B2/en not_active Expired
- 1976-03-11 PL PL1976187846A patent/PL103510B1/pl unknown
- 1976-03-11 IE IE504/76A patent/IE42506B1/en unknown
- 1976-03-11 AT AT180576A patent/AT349153B/de not_active IP Right Cessation
- 1976-03-11 IE IE2561/77A patent/IE42507B1/en unknown
- 1976-03-11 FR FR7606937A patent/FR2304084A1/fr active Granted
- 1976-03-12 JP JP51027019A patent/JPS5278866A/ja active Granted
- 1976-03-12 CA CA248,333A patent/CA1055824A/en not_active Expired
- 1976-11-10 US US05/740,462 patent/US4260777A/en not_active Expired - Lifetime
1977
- 1977-05-23 SU SU772482007A patent/SU625610A3/ru active

Also Published As

Publication number	Publication date
FR2304084A1 (fr)	1976-10-08
SE7602134L (sv)	1976-09-13
ATA180576A (de)	1978-08-15
IT1056947B (it)	1982-02-20
FR2304084B1 (da)	1981-06-26
CH627000A5 (da)	1981-12-15
NL7602442A (nl)	1976-09-14
DE2510633B2 (de)	1977-11-10
SU625610A3 (ru)	1978-09-25
LU74519A1 (da)	1976-09-01
SU633501A3 (ru)	1978-11-15
DE2510633C3 (de)	1978-07-13
AU501932B2 (en)	1979-07-05
DE2510633A1 (de)	1976-09-16
ES445808A1 (es)	1977-06-01
HU172450B (hu)	1978-09-28
NL164966C (nl)	1981-02-16
IE42506L (en)	1976-09-12
IE42507B1 (en)	1980-08-27
SE423754B (sv)	1982-05-24
BE839363A (fr)	1976-09-09
CS190526B2 (en)	1979-05-31
DK103276A (da)	1976-09-13
US4013416A (en)	1977-03-22
AT349153B (de)	1979-03-26
IE42507L (en)	1976-09-12
DK144443B (da)	1982-03-08
NL164966B (nl)	1980-09-15
AU1189576A (en)	1977-09-15
YU59476A (en)	1988-10-31
CA1055824A (en)	1979-06-05
IL49167A0 (en)	1976-05-31
FI760578A7 (da)	1976-09-13
DD129788A5 (de)	1978-02-08
PL103510B1 (pl)	1979-06-30
JPS5278866A (en)	1977-07-02
IL49167A (en)	1978-08-31
DK144443C (da)	1982-08-23
IE42506B1 (en)	1980-08-27
DD125021A5 (da)	1977-03-23
US4260777A (en)	1981-04-07
FI59678B (fi)	1981-05-29
GB1487718A (en)	1977-10-05
GB1487717A (en)	1977-10-05
JPS5751627B2 (da)	1982-11-02

Legal Events

Date	Code	Title	Description
1976-03-05	MA	Patent expired
2004-08-31	MA	Patent expired	Owner name: BOEHRINGER MANNHEIM GMBH

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