FI894541A7 - Aids-laekemedel baserade pao hiv-proteasinhibitorer. - Google Patents

Aids-laekemedel baserade pao hiv-proteasinhibitorer. Download PDF

Info

Publication number
FI894541A7
FI894541A7 FI894541A FI894541A FI894541A7 FI 894541 A7 FI894541 A7 FI 894541A7 FI 894541 A FI894541 A FI 894541A FI 894541 A FI894541 A FI 894541A FI 894541 A7 FI894541 A7 FI 894541A7
Authority
FI
Finland
Prior art keywords
proteasinhibitorer
laekemedel
hiv
aids
baserade
Prior art date
Application number
FI894541A
Other languages
English (en)
Finnish (fi)
Other versions
FI894541A0 (fi
Inventor
Rudolf H Hanko
George A Scangos
Heeja Yoo-Warren
Triprayar V Ramabhadran
Arnold Paessens
Rolf Henning
Paul Perry Tamburini
Dieter Hoppe
Jutta Hansen
Klaus Rabe
Original Assignee
Molecular Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Therapeutics Inc filed Critical Molecular Therapeutics Inc
Publication of FI894541A0 publication Critical patent/FI894541A0/fi
Publication of FI894541A7 publication Critical patent/FI894541A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI894541A 1988-09-28 1989-09-26 Aids-laekemedel baserade pao hiv-proteasinhibitorer. FI894541A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25047288A 1988-09-28 1988-09-28
US38619489A 1989-08-01 1989-08-01

Publications (2)

Publication Number Publication Date
FI894541A0 FI894541A0 (fi) 1989-09-26
FI894541A7 true FI894541A7 (fi) 1990-03-29

Family

ID=26940904

Family Applications (1)

Application Number Title Priority Date Filing Date
FI894541A FI894541A7 (fi) 1988-09-28 1989-09-26 Aids-laekemedel baserade pao hiv-proteasinhibitorer.

Country Status (8)

Country Link
EP (1) EP0361341A3 (fr)
JP (1) JPH02191243A (fr)
AU (1) AU633017B2 (fr)
DK (1) DK476089A (fr)
FI (1) FI894541A7 (fr)
IL (1) IL91768A0 (fr)
NO (1) NO893834L (fr)
PT (1) PT91828A (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
US5539122A (en) * 1989-05-23 1996-07-23 Abbott Laboratories Retroviral protease inhibiting compounds
WO1991008221A1 (fr) * 1989-12-04 1991-06-13 Wisconsin Alumni Research Foundation Inhibiteurs de peptides de protease d'hiv
EP0665215A1 (fr) * 1990-06-01 1995-08-02 The Du Pont Merck Pharmaceutical Company 1,4-diamino-2,3-dihydroxybutanes
EP0572547A1 (fr) * 1991-02-22 1993-12-08 The Du Pont Merck Pharmaceutical Company $g(a)-AMINOALDEHYDES SUBSTITUES ET LEURS DERIVES
CN1071930A (zh) * 1991-07-10 1993-05-12 伊莱利利公司 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂
US5508407A (en) * 1991-07-10 1996-04-16 Eli Lilly And Company Retroviral protease inhibitors
US5554728A (en) * 1991-07-23 1996-09-10 Nexstar Pharmaceuticals, Inc. Lipid conjugates of therapeutic peptides and protease inhibitors
WO1993008404A1 (fr) * 1991-10-14 1993-04-29 Cash Engineering Research Pty. Ltd. Combinaison de commande d'admission pour systeme de compresseur
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
JPH07504654A (ja) * 1992-03-11 1995-05-25 ナルヘックス リミテッド オキソ及びヒドロキシ置換炭化水素のアミン誘導体
ZA931777B (en) * 1992-03-13 1993-09-23 Bio Mega Boehringer Ingelheim Substituted pyrrolidine derivatives as HIV protease inhibitors.
ES2066623T3 (es) * 1992-03-13 1995-03-01 Bio Mega Boehringer Ingelheim Derivados sustituidos del acido pipecolinico como inhibidores de la vih-proteasa.
NZ247837A (en) * 1992-06-19 1995-04-27 Lilly Co Eli Cyclic oxirane derivatives, medicaments and precursors
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5846993A (en) * 1992-12-22 1998-12-08 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
ES2150933T3 (es) * 1992-12-22 2000-12-16 Lilly Co Eli Inhibidores de la proteasa vih utiles para el tratamiento del sida.
US5484926A (en) 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
MX9308025A (es) * 1992-12-22 1994-08-31 Lilly Co Eli Compuestos inhibidores de la proteasa del virus dela inmunodeficiencia humana, procedimiento para supreparacion y formulacion farmaceutica que los contiene.
MX9308016A (es) * 1992-12-22 1994-08-31 Lilly Co Eli Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene.
US5733906A (en) * 1993-10-12 1998-03-31 Eli Lilly And Company Inhibitors of HIV Protease useful for the treatment of Aids
US5434265A (en) * 1992-12-22 1995-07-18 Eli Lilly And Company Inhibitors of HIV protease
US5475136A (en) * 1992-12-22 1995-12-12 Eli Lilly And Company Inhibitors of HIV protease useful for the treatment of AIDS
US5491166A (en) * 1992-12-22 1996-02-13 Eli Lilly And Company Inhibitors of HIV protease useful for the treatment of AIDS
US5554653A (en) * 1992-12-22 1996-09-10 Eli Lilly And Company Inhibitors of HIV protease useful for the treatment of AIDS
US5686469A (en) * 1993-02-09 1997-11-11 Miles Inc. Aminomethylene derivaties as immunosuppressants
US5385918A (en) * 1993-02-09 1995-01-31 Miles Inc. Aminomethylene-peptides as immunosuppressants
EP0610745A3 (en) * 1993-02-09 1994-09-28 Miles Inc Novel aminomethylene derivatives as immunosuppressants.
ES2124327T3 (es) * 1993-02-09 1999-02-01 Bayer Ag Derivados de sulfonamida aminometileno como inmunosupresores.
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
KR0125117B1 (ko) 1994-06-15 1997-12-05 성재갑 항 에이즈(aids)효과를 갖는 신규한 인간 면역 결핍 바이러스(hiv)프로테아제 억제 화합물 및 그의 제조방법
US5480887A (en) * 1994-02-02 1996-01-02 Eli Lilly And Company Protease inhibitors
CA2182090A1 (fr) * 1994-02-02 1995-08-10 William Joseph Hornback Inhibiteurs de la protease du vih et leurs intermediaires
US5527829A (en) * 1994-05-23 1996-06-18 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5962725A (en) 1996-09-05 1999-10-05 Agouron Pharmaceuticals, Inc. Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir
US5705647A (en) * 1996-09-05 1998-01-06 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US5925759A (en) 1996-09-05 1999-07-20 Agouron Pharmaceuticals, Inc. Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
US6001851A (en) * 1997-03-13 1999-12-14 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US6084107A (en) * 1997-09-05 2000-07-04 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
FR2834989B1 (fr) * 2002-01-18 2005-05-20 Commissariat Energie Atomique Derives de pseudo-peptides phosphiniques inhibant selectivement le site actif c-terminal de l'enzyme de conversion de l'angiotensine i(ace)
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
EP1702916A1 (fr) * 2005-03-18 2006-09-20 Santhera Pharmaceuticals (Schweiz) GmbH Inhibiteurs de DPP-IV
US8106090B2 (en) 2005-07-20 2012-01-31 Eli Lilly And Company 1-amino linked compounds
JP2010512389A (ja) 2006-12-12 2010-04-22 シェーリング コーポレイション アスパルチルプロテアーゼ阻害剤
CN116948019A (zh) * 2011-05-17 2023-10-27 洛克菲勒大学 人类免疫缺陷病毒中和抗体及其使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02502457A (ja) * 1987-03-09 1990-08-09 ジ・アップジョン・カンパニー シクロプロピル含有レニン抑制ペプチド
WO1989003842A1 (fr) * 1987-10-21 1989-05-05 The Upjohn Company Inhibiteurs de renine contenant une fraction de (1-amino-2-hydroxy-2-heterocyclique) ethyle
CA1340588C (fr) * 1988-06-13 1999-06-08 Balraj Krishan Handa Derive d'aminoacides
IL90872A0 (en) * 1988-07-08 1990-02-09 Smithkline Beckman Corp Retroviral protease binding peptides

Also Published As

Publication number Publication date
JPH02191243A (ja) 1990-07-27
NO893834L (no) 1990-03-29
EP0361341A3 (fr) 1991-07-03
PT91828A (pt) 1990-03-30
EP0361341A2 (fr) 1990-04-04
DK476089D0 (da) 1989-09-27
AU633017B2 (en) 1993-01-21
FI894541A0 (fi) 1989-09-26
IL91768A0 (en) 1990-06-10
NO893834D0 (no) 1989-09-27
DK476089A (da) 1990-03-29
AU4230889A (en) 1990-08-16

Similar Documents

Publication Publication Date Title
FI895343A0 (fi) Pao multivaoglaengd arbetande medicinskt lasersystem.
FI882907A7 (fi) Lekadetektor och -lokalisator baserad pao tidreflektometri- och provtagningsteknik.
FI881669A7 (fi) Infaestning pao ihaoligt underlag.
DE68917891D1 (de) Hörgerätewandler.
FI921077A0 (fi) Pao monocyklopentadienyloevergaongsmetaller baserade olefinpolymerisationskatalysatorer.
FI893962L (fi) Vid vaord av aids anvaendbara hiv-proteas -inhibitorer.
FI885971L (fi) Antiskummedel baserad pao olja-i vatten-emulsioner.
FI895190A0 (fi) Ask av falskartong foer uppbevaring av pao varandra staplade hygiendukar.
FI902795A0 (fi) Immunogenkonjugat foer aids.
FI884908L (fi) Elledande mikroemulsioner baserade pao perfluorpolyetrar.
FI880091L (fi) Vaermehaerdbara sammansaettningar baserade pao imid- och epoxygrupper.
DE58906141D1 (de) Hörgerät.
FI885379L (fi) Faestanordning foer glasskivefoerpackningar pao en transportvagn.
DE69000385D1 (de) Verfahrenshilfsmittel.
FI915683A0 (fi) Foerfarande foer att producera manganinnehaollande fosfatbelaeggningar pao metallytor.
FI880096L (fi) Taetningsfoerfande foer membran pao vattenavskiljare i gasanalysapparat.
FI900269A0 (fi) Framstaellningsfoerfarande foer skida pao dettta saett framstaelld skida.
FI892104A7 (fi) Foerfarande foer identifiering av aluminiumlegeringar pao elektrokemisk vaeg.
FI885475A0 (fi) Pao vaegg glidande foervaringssystem foer cyklar.
FI872377A7 (fi) Laosanordning foer skivor pao en tyngdlyftningsstaong.
FI882230A0 (fi) Stabiliseringsaemnen foer plaster pao glutaratbasis.
FI884743A7 (fi) Saett att foerhindra aelgar fraon att traeda pao landsvaeg.
FI883520A0 (fi) Anordning pao skida.
FI885658A0 (fi) Pao telefonsystem baserat kontrollfoerfarande.
FI77077B (fi) Oljeuppsamlingsanordning foer oljebekaempning pao vattenomraoden.

Legal Events

Date Code Title Description
FA Application withdrawn [patent]

Owner name: MOLECULAR THERAPEUTICS, INC.