FI925731A0 - Polycykliska guaninderivat - Google Patents

Polycykliska guaninderivat

Info

Publication number: FI925731A0
Authority: FI; Finland
Prior art keywords: aryl; alkyl; heteroaryl; hydrogen; pct
Prior art date: 1990-06-21

Application number

FI925731A

Other languages

English (en)

Finnish (fi)

Other versions

FI925731A7 (fi

Inventor

Bernard R Neustadt

Neil A Lindo

Brian A Mckittrick

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-21

Filing date

1992-12-17

Publication date

1992-12-17

1992-12-17 Application filed by Schering Corp filed Critical Schering Corp

1992-12-17 Publication of FI925731A0 publication Critical patent/FI925731A0/fi

1992-12-17 Publication of FI925731A7 publication Critical patent/FI925731A7/fi

Links

125000000217 alkyl group Chemical group 0.000 abstract 8
125000003118 aryl group Chemical group 0.000 abstract 6
125000001072 heteroaryl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical group 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004663 dialkyl amino group Chemical group 0.000 abstract 3
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000005122 aminoalkylamino group Chemical group 0.000 abstract 1
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
230000003182 bronchodilatating effect Effects 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 1
-1 monoalkylamino Chemical group 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Filtering Materials (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

FI925731A 1990-06-21 1992-12-17 Polycykliska guaninderivat FI925731A7 (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US54156890A	1990-06-21	1990-06-21
PCT/US1991/004154 WO1991019717A1 (en)	1990-06-21	1991-06-20	Polycyclic guanine derivatives

Publications (2)

Publication Number	Publication Date
FI925731A0 true FI925731A0 (fi)	1992-12-17
FI925731A7 FI925731A7 (fi)	1992-12-17

Family

ID=24160139

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI925731A FI925731A7 (fi)	1990-06-21	1992-12-17	Polycykliska guaninderivat

Country Status (21)

Country	Link
US (1)	US5393755A (de)
EP (1)	EP0538332B1 (de)
JP (1)	JPH0747589B2 (de)
KR (1)	KR960004532B1 (de)
AT (1)	ATE155786T1 (de)
AU (1)	AU651607B2 (de)
CA (1)	CA2085733C (de)
CZ (1)	CZ281920B6 (de)
DE (1)	DE69126980T2 (de)
FI (1)	FI925731A7 (de)
HU (1)	HUT65623A (de)
IE (1)	IE912126A1 (de)
IL (1)	IL98559A0 (de)
NO (1)	NO924940L (de)
NZ (1)	NZ238609A (de)
OA (1)	OA09723A (de)
PL (1)	PL169481B1 (de)
RU (1)	RU2080322C1 (de)
TW (1)	TW197441B (de)
WO (1)	WO1991019717A1 (de)
ZA (1)	ZA914727B (de)

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US5939419A (en) *	1993-02-26	1999-08-17	Schering-Plough Corporation	2-benzyl-polycyclic guanine derivatives and process for preparing them
US5929046A (en) *	1994-06-08	1999-07-27	Cancer Research Campaign Technology Limited	Pyrimidine and purine derivatives and their use in treating tumour cells
US5661153A (en) *	1994-07-19	1997-08-26	Japan Energy Corporation	1-arylpyrimidine derivatives and pharmaceutical use thereof
US5824683A (en) *	1995-11-28	1998-10-20	Schering Corporation	2'- 4'-halo- 1,1'-biphenyl!-4-yl!methyl!-5'-methyl-spiro cyclopentane-1,7' (8'H)- 3H! imidazo 2,1-b!purin!-4' (5'H)-ones
AR004752A1 (es) *	1995-11-28	1999-03-10	Schering Corp	2'-[[4'-halo-[1,1'-bifenil]-4-il]metil]-5'-metil-espiro[ciclopentano-1,7' (8'h)-[3h imidazo[2,1-b]purin]-4'(5'h)-onas, uso del mismo para la preparacionde un medicamento, composicion farmaceutica y un proceso para su preparacion.
CA2238283C (en) *	1997-05-30	2002-08-20	Cell Pathways, Inc.	Method for identifying compounds for inhibition of neoplastic lesions, pharmaceutical compositions from such compounds and uses of such compounds and compositions for treating neoplastic lesions
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US6133271A (en) *	1998-11-19	2000-10-17	Cell Pathways, Inc.	Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
US6187779B1 (en)	1998-11-20	2001-02-13	Cell Pathways, Inc.	Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
US6369092B1 (en)	1998-11-23	2002-04-09	Cell Pathways, Inc.	Method for treating neoplasia by exposure to substituted benzimidazole derivatives
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US6486155B1 (en)	1998-11-24	2002-11-26	Cell Pathways Inc	Method of inhibiting neoplastic cells with isoquinoline derivatives
US6034099A (en) *	1998-11-24	2000-03-07	Cell Pathways, Inc.	Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
US6025394A (en)	1999-01-29	2000-02-15	Cell Pathways, Inc.	Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
US6020379A (en) *	1999-02-19	2000-02-01	Cell Pathways, Inc.	Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
ES2166270B1 (es) *	1999-07-27	2003-04-01	Almirall Prodesfarma Sa	Derivados de 8-fenil-6,9-dihidro-(1,2,4,)triazolo(3,4-i)purin-5-ona.
US6555547B1 (en)	2000-02-28	2003-04-29	Cell Pathways, Inc.	Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative
US6569638B1 (en)	2000-03-03	2003-05-27	Cell Pathways, Inc	Method for screening compounds for the treatment of neoplasia
US6821978B2 (en)	2000-09-19	2004-11-23	Schering Corporation	Xanthine phosphodiesterase V inhibitors
ATE395349T1 (de) *	2001-08-28	2008-05-15	Schering Corp	Polycyclische guanin phosphodiesterase inhibitoren
EP1790652A1 (de) *	2001-08-28	2007-05-30	Schering Corporation	Polycyclische Guanin Phosphodiesterase V Inhibitoren
IL160307A0 (en)	2001-08-31	2004-07-25	Univ Rockefeller	Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain
EP1312363A1 (de) *	2001-09-28	2003-05-21	Pfizer Products Inc.	Behandlungsverfahren und kits bestehend aus Wachstumshormonsekretionsförderern
CA2465893A1 (en) *	2001-11-09	2003-05-22	Schering Corporation	Polycyclic guanine derivative phosphodiesterase v inhibitors
US7342884B2 (en) *	2002-03-13	2008-03-11	Harmonic, Inc.	Method and apparatus for one directional communications in bidirectional communications channel
SI1509525T1 (sl)	2002-05-31	2006-12-31	Schering Corp	Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
DE60307628T2 (de) *	2002-05-31	2007-08-09	Schering Corporation	Verfahren zur herstellung von xanthin phosphodiesterase v inhibitoren und deren vorstufen
WO2005012303A1 (en) *	2003-07-31	2005-02-10	Schering Corporation	Metabolite of xanthine phosphodiesterase 5 inhibitor and derivatives thereof useful for treatment of erectile dysfunction
WO2005012293A1 (ja) *	2003-08-01	2005-02-10	Nippon Soda Co., Ltd.	フェニルアゾール化合物、製造法および抗酸化薬
KR20060101762A (ko) *	2003-11-21	2006-09-26	쉐링 코포레이션	포스포디에스테라제 ｖ 억제제 제형
US20070004745A1 (en) *	2005-03-25	2007-01-04	Schering-Plough Corporation	Methods of treating benign prostatic hyperplasia or lower urinary tract symptoms by using PDE 5 inhibitors
AU2006255028B2 (en) *	2005-06-06	2012-04-19	Intra-Cellular Therapies, Inc.	Organic compounds
US20080194592A1 (en) *	2005-08-23	2008-08-14	Intra-Cellular Therapies, Inc.	Organic Compounds
US7884202B2 (en)	2005-11-09	2011-02-08	Tosoh Corporation	Nucleobase having perfluoroalkyl group and process for producing the same
GB0601951D0 (en)	2006-01-31	2006-03-15	Novartis Ag	Organic compounds
KR20090042227A (ko)	2006-06-06	2009-04-29	인트라-셀룰라 써래피스, 인코퍼레이티드.	유기 화합물
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WO2008070095A1 (en)	2006-12-05	2008-06-12	Intra-Cellular Therapies, Inc.	Novel uses
KR20100023040A (ko) *	2007-06-21	2010-03-03	쉐링 코포레이션	폴리사이클릭 구아닌 유도체 및 이의 용도
KR20120012831A (ko)	2007-12-06	2012-02-10	인트라-셀룰라 써래피스, 인코퍼레이티드.	유기 화합물
EP2240028B1 (de) *	2007-12-06	2016-07-20	Intra-Cellular Therapies, Inc.	Pyrazolopyrimidine-4,6-dione derivate und deren Anwendung als Pharmaceutika
KR20110103949A (ko) *	2008-12-06	2011-09-21	인트라-셀룰라 써래피스, 인코퍼레이티드.	유기 화합물
MA32942B1 (fr)	2008-12-06	2012-01-02	Intra Cellular Therapies Inc	Composes organiques
JP5778582B2 (ja)	2008-12-06	2015-09-16	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	有機化合物
EP2367430B1 (de)	2008-12-06	2014-08-13	Intra-Cellular Therapies, Inc.	Organische verbindungen
EP2367431B1 (de)	2008-12-06	2015-08-05	Intra-Cellular Therapies, Inc.	Organische verbindungen
BRPI0922809A2 (pt)	2008-12-06	2018-05-29	Intracellular Therapies Inc	compostos orgânicos
WO2010098839A1 (en)	2009-02-25	2010-09-02	Intra-Cellular Therapies, Inc.	Pde 1 inhibitors for ophthalmic disorders
AU2010222289B2 (en)	2009-03-13	2013-07-11	Advinus Therapeutics Private Limited	Substituted fused pyrimidine compounds
JP2012526810A (ja)	2009-05-13	2012-11-01	イントラ−セルラー・セラピーズ・インコーポレイテッド	有機化合物
JP6166534B2 (ja)	2009-08-05	2017-07-19	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	新規調節タンパク質および阻害剤
WO2011081915A2 (en) *	2009-12-15	2011-07-07	Cebix Inc.	Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
TW201206937A (en)	2010-05-31	2012-02-16	Intra Cellular Therapies Inc	Organic compounds
WO2011153135A1 (en)	2010-05-31	2011-12-08	Intra-Cellular Therapies, Inc.	Organic compounds
EP2576551A4 (de)	2010-05-31	2014-04-16	Intra Cellular Therapies Inc	Organische verbindungen
WO2011153136A1 (en)	2010-05-31	2011-12-08	Intra-Cellular Therapies, Inc.	Organic compounds
JP6051210B2 (ja)	2011-06-10	2016-12-27	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	有機化合物
US9801882B2 (en)	2013-02-17	2017-10-31	Intra-Cellular Therapies, Inc.	Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases
EP2968338B1 (de)	2013-03-15	2019-01-09	Intra-Cellular Therapies, Inc.	Pde1-inhibitoren zur verwendung bei der behandlung und/oder prävention von zns-verletzungen und pns-krankheiten, störungen oder verletzungen
KR102240326B1 (ko)	2013-03-15	2021-04-13	인트라-셀룰라 써래피스, 인코퍼레이티드.	유기 화합물
JP6696904B2 (ja)	2014-01-08	2020-05-20	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	製剤および医薬組成物
EP3157926B1 (de)	2014-06-20	2019-05-15	Intra-Cellular Therapies, Inc.	Organische verbindungen
US10285992B2 (en)	2014-08-07	2019-05-14	Intra-Cellular Therapies, Inc.	Combinations of PDE1 inhibitors and NEP inhibitors and associated methods
US10131671B2 (en)	2014-08-07	2018-11-20	Intra-Cellular Therapies, Inc.	Organic compounds
US9546175B2 (en)	2014-08-07	2017-01-17	Intra-Cellular Therapies, Inc.	Organic compounds
CA2961212C (en)	2014-09-17	2024-02-06	Intra-Cellular Therapies, Inc.	Compounds and methods
CA2969594A1 (en)	2014-12-06	2016-06-09	Intra-Cellular Therapies, Inc.	Pde2 inhibiting organic compounds
HK1244427A1 (zh)	2014-12-06	2018-08-10	Intra-Cellular Therapies, Inc.	有机化合物
US10682354B2 (en)	2016-03-28	2020-06-16	Intra-Cellular Therapies, Inc.	Compositions and methods
JP7134168B6 (ja)	2016-09-12	2024-02-02	イントラ－セルラー・セラピーズ・インコーポレイテッド	新規使用
KR102590848B1 (ko)	2016-12-28	2023-10-19	다트 뉴로사이언스, 엘엘씨	Pde2 억제제로서 치환된 피라졸로피리미디논 화합물
DK3717488T3 (da)	2017-11-27	2021-12-13	Dart Neuroscience Llc	Substituerede furanopyrimidinforbindelser som pde1-inhibitorer
JP7401442B2 (ja)	2018-01-31	2023-12-19	イントラ－セルラー・セラピーズ・インコーポレイテッド	新規使用
EP4413980A3 (de)	2019-09-03	2024-10-30	Intra-Cellular Therapies, Inc.	Neue verbindungen
US12364695B2 (en)	2020-06-02	2025-07-22	Intra-Cellular Therapies, Inc.	Methods of treating inflammatory disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1095906A (en) *	1977-02-14	1981-02-17	Davis L. Temple, Jr.	Heterocyclopyrimidines, compositions and therapeutic process
BE863525A (fr) *	1977-02-14	1978-07-31	Bristol Myers Co	Heterocyclopyrimidines
AU623755B2 (en) *	1989-03-29	1992-05-21	Merrell Pharmaceuticals Inc.	Selective adenosine receptor compounds
US5064947A (en) *	1989-03-29	1991-11-12	Merrell Dow Pharmaceuticals Inc.	Selective adenosine reseptor compounds
US5173492A (en) *	1989-09-14	1992-12-22	Kyowa Hakko Kogyo Co., Ltd.	s-Triazolo(3,4-I)purine derivatives
DE69033614T2 (de) *	1989-10-20	2001-04-19	Kyowa Hakko Kogyo K.K., Tokio/Tokyo	Kondensierte Purinderivate

1991
- 1991-06-19 NZ NZ238609A patent/NZ238609A/en unknown
- 1991-06-19 ZA ZA914727A patent/ZA914727B/xx unknown
- 1991-06-19 IL IL98559A patent/IL98559A0/xx unknown
- 1991-06-20 CA CA002085733A patent/CA2085733C/en not_active Expired - Fee Related
- 1991-06-20 IE IE212691A patent/IE912126A1/en unknown
- 1991-06-20 AU AU81992/91A patent/AU651607B2/en not_active Ceased
- 1991-06-20 AT AT91912779T patent/ATE155786T1/de not_active IP Right Cessation
- 1991-06-20 WO PCT/US1991/004154 patent/WO1991019717A1/en not_active Ceased
- 1991-06-20 PL PL91297299A patent/PL169481B1/pl unknown
- 1991-06-20 DE DE69126980T patent/DE69126980T2/de not_active Expired - Fee Related
- 1991-06-20 JP JP3512084A patent/JPH0747589B2/ja not_active Expired - Fee Related
- 1991-06-20 CZ CS923749A patent/CZ281920B6/cs unknown
- 1991-06-20 US US07/949,811 patent/US5393755A/en not_active Expired - Lifetime
- 1991-06-20 EP EP91912779A patent/EP0538332B1/de not_active Expired - Lifetime
- 1991-06-20 RU RU9192016466A patent/RU2080322C1/ru active
- 1991-06-20 HU HU9204032A patent/HUT65623A/hu unknown
- 1991-06-20 TW TW080104761A patent/TW197441B/zh active
- 1991-06-20 KR KR1019920703316A patent/KR960004532B1/ko not_active Expired - Fee Related
1992
- 1992-12-17 FI FI925731A patent/FI925731A7/fi not_active Application Discontinuation
- 1992-12-18 NO NO92924940A patent/NO924940L/no unknown
- 1992-12-21 OA OA60319A patent/OA09723A/en unknown

Also Published As

Publication number	Publication date
US5393755A (en)	1995-02-28
HU9204032D0 (en)	1993-03-29
ATE155786T1 (de)	1997-08-15
HUT65623A (en)	1994-07-28
FI925731A7 (fi)	1992-12-17
IE912126A1 (en)	1992-01-01
EP0538332B1 (de)	1997-07-23
CA2085733C (en)	1996-03-05
CA2085733A1 (en)	1991-12-22
AU651607B2 (en)	1994-07-28
TW197441B (de)	1993-01-01
NO924940D0 (no)	1992-12-18
WO1991019717A1 (en)	1991-12-26
CZ281920B6 (cs)	1997-04-16
NO924940L (no)	1992-12-18
EP0538332A1 (de)	1993-04-28
RU2080322C1 (ru)	1997-05-27
NZ238609A (en)	1993-12-23
JPH0747589B2 (ja)	1995-05-24
JPH05508647A (ja)	1993-12-02
PL169481B1 (pl)	1996-07-31
DE69126980D1 (de)	1997-09-04
DE69126980T2 (de)	1998-01-08
AU8199291A (en)	1992-01-07
IL98559A0 (en)	1992-07-15
ZA914727B (en)	1992-03-25
CZ374992A3 (en)	1993-10-13
OA09723A (en)	1993-08-30
PL297299A1 (de)	1992-07-13
KR960004532B1 (ko)	1996-04-06

Legal Events

Date	Code	Title	Description
1997-01-19	FD	Application lapsed

Publication	Publication Date	Title
FI925731A0 (fi)	1992-12-17	Polycykliska guaninderivat
ATE275134T1 (de)	2004-09-15	4-oxo-1,4-dihydro-3-chinolincarboxamide als antivirale mittel
ATE155133T1 (de)	1997-07-15	Piperazinderivate als 5-ht antagonisten
ES2164666T3 (es)	2002-03-01	Compuestos plaguicidas de pirimidina.
DE69327913D1 (de)	2000-04-06	1,2,4-Oxadiazolyl-Phenoxyalkyl-isoxazole und ihre Anwendung als antivirale Mittel
DE69321609D1 (de)	1998-11-19	Piperazinderivate
DE69431471D1 (de)	2002-11-07	Amide derivate als 5-ht1a liganden
DE69104475D1 (de)	1994-11-10	Harnstoffderivate, ihre herstellung und deren enthaltende arzneimittel.
DE69416311D1 (de)	1999-03-11	Verwendung von cephem-derivaten als antimetastatische mittel
ATE172724T1 (de)	1998-11-15	Anthelmintische benzimidazole
KR970706280A (ko)	1997-11-03	5-HT1A 길항제로서의 비사이클릭 카복스아미드(Bicyclic carboxamides as 5-HT1 antagonists)
DE69403896D1 (de)	1997-07-24	4-amino-2-(hetero)aryl-butanamide verwenbar als 5-ht1a-antagonisten
DK0719271T3 (da)	1997-12-29	5-(1-Fluorvinyl)-1H-pyrimidin-2,4-dion-derivater som antineoplastiske midler
ATE119883T1 (de)	1995-04-15	Thioformamidderivate.