DK3717488T3 - Substituerede furanopyrimidinforbindelser som pde1-inhibitorer - Google Patents
Substituerede furanopyrimidinforbindelser som pde1-inhibitorer Download PDFInfo
- Publication number
- DK3717488T3 DK3717488T3 DK18819287.6T DK18819287T DK3717488T3 DK 3717488 T3 DK3717488 T3 DK 3717488T3 DK 18819287 T DK18819287 T DK 18819287T DK 3717488 T3 DK3717488 T3 DK 3717488T3
- Authority
- DK
- Denmark
- Prior art keywords
- furanopyrimidi
- substituted
- compounds
- pde1 inhibitors
- pde1
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762591105P | 2017-11-27 | 2017-11-27 | |
| PCT/US2018/062493 WO2019104285A1 (en) | 2017-11-27 | 2018-11-26 | Substituted furanopyrimidine compounds as pde1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3717488T3 true DK3717488T3 (da) | 2021-12-13 |
Family
ID=64665119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18819287.6T DK3717488T3 (da) | 2017-11-27 | 2018-11-26 | Substituerede furanopyrimidinforbindelser som pde1-inhibitorer |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11434247B1 (da) |
| EP (1) | EP3717488B1 (da) |
| JP (1) | JP7254078B2 (da) |
| KR (1) | KR102794907B1 (da) |
| CN (1) | CN111655695B (da) |
| AU (1) | AU2018373258B2 (da) |
| CA (1) | CA3120971A1 (da) |
| DK (1) | DK3717488T3 (da) |
| ES (1) | ES2902365T3 (da) |
| MX (2) | MX2020005447A (da) |
| WO (1) | WO2019104285A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102590848B1 (ko) | 2016-12-28 | 2023-10-19 | 다트 뉴로사이언스, 엘엘씨 | Pde2 억제제로서 치환된 피라졸로피리미디논 화합물 |
| ES2902365T3 (es) | 2017-11-27 | 2022-03-28 | Dart Neuroscience Llc | Compuestos de furanopirimidina sustituidos como inhibidores de PDE1 |
| US20220289751A1 (en) * | 2019-07-17 | 2022-09-15 | Ono Pharmaceutical Co., Ltd. | Compound having kdm5 inhibitory activity and pharmaceutical use thereof |
| TWI901650B (zh) | 2020-03-26 | 2025-10-21 | 匈牙利商羅特格登公司 | 啶及吡啶并〔３，４－ｃ〕嗒衍生物 |
| US20240043400A1 (en) * | 2020-12-03 | 2024-02-08 | UCB Biopharma SRL | Octahydroisoquinolinyl Derivatives |
| EP4380561A4 (en) * | 2021-08-06 | 2025-06-25 | Rayzebio, Inc. | Conjugates comprising covalent binders for targeting intracellular kras g12c proteins |
| US20250049748A1 (en) * | 2021-12-16 | 2025-02-13 | Terran Biosciences Inc. | Analogs of 4-bromo-2,5-dimethoxyphenethylamine |
| CN117263843A (zh) * | 2023-06-16 | 2023-12-22 | 常州大学 | 一种多巴胺d2样受体双位配体化合物及其应用 |
| WO2025036472A1 (en) * | 2023-08-16 | 2025-02-20 | Pharmaengine, Inc. | Spirocyclic mta-cooperative prmts inhibitor |
| WO2025255013A1 (en) * | 2024-06-03 | 2025-12-11 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CN121159506A (zh) * | 2024-06-17 | 2025-12-19 | 青岛清原化合物有限公司 | 取代的芳基酰胺化合物或其盐及其制备方法、组合物和应用 |
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| KR102590848B1 (ko) | 2016-12-28 | 2023-10-19 | 다트 뉴로사이언스, 엘엘씨 | Pde2 억제제로서 치환된 피라졸로피리미디논 화합물 |
| US20190177327A1 (en) | 2017-10-13 | 2019-06-13 | Dart Neuroscience, Llc | Substituted methyl pyrazolopyrimidinone and methyl imidazopyrazinone compounds as pde1 inhibitors |
| ES2902365T3 (es) | 2017-11-27 | 2022-03-28 | Dart Neuroscience Llc | Compuestos de furanopirimidina sustituidos como inhibidores de PDE1 |
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2018
- 2018-11-26 ES ES18819287T patent/ES2902365T3/es active Active
- 2018-11-26 DK DK18819287.6T patent/DK3717488T3/da active
- 2018-11-26 US US16/766,258 patent/US11434247B1/en active Active
- 2018-11-26 EP EP18819287.6A patent/EP3717488B1/en active Active
- 2018-11-26 CN CN201880087700.5A patent/CN111655695B/zh active Active
- 2018-11-26 AU AU2018373258A patent/AU2018373258B2/en active Active
- 2018-11-26 JP JP2020528933A patent/JP7254078B2/ja active Active
- 2018-11-26 MX MX2020005447A patent/MX2020005447A/es unknown
- 2018-11-26 WO PCT/US2018/062493 patent/WO2019104285A1/en not_active Ceased
- 2018-11-26 KR KR1020207018585A patent/KR102794907B1/ko active Active
- 2018-11-26 CA CA3120971A patent/CA3120971A1/en active Pending
-
2020
- 2020-07-13 MX MX2023004603A patent/MX2023004603A/es unknown
-
2022
- 2022-09-02 US US17/902,730 patent/US12006325B2/en active Active
-
2024
- 2024-06-07 US US18/737,420 patent/US20250145633A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR102794907B1 (ko) | 2025-04-14 |
| AU2018373258A1 (en) | 2020-07-16 |
| KR20200108419A (ko) | 2020-09-18 |
| ES2902365T3 (es) | 2022-03-28 |
| EP3717488B1 (en) | 2021-09-29 |
| MX2023004603A (es) | 2023-05-08 |
| WO2019104285A1 (en) | 2019-05-31 |
| AU2018373258B2 (en) | 2023-03-02 |
| JP2021504380A (ja) | 2021-02-15 |
| US20230295178A1 (en) | 2023-09-21 |
| EP3717488A1 (en) | 2020-10-07 |
| US20250145633A1 (en) | 2025-05-08 |
| US12006325B2 (en) | 2024-06-11 |
| CN111655695B (zh) | 2025-05-27 |
| MX2020005447A (es) | 2020-12-03 |
| US11434247B1 (en) | 2022-09-06 |
| CA3120971A1 (en) | 2019-05-31 |
| CN111655695A (zh) | 2020-09-11 |
| JP7254078B2 (ja) | 2023-04-07 |
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