FI930220L - Oligonukleotidsanaloger, deras framstaellning och anvaendning - Google Patents

Oligonukleotidsanaloger, deras framstaellning och anvaendning Download PDF

Info

Publication number
FI930220L
FI930220L FI930220A FI930220A FI930220L FI 930220 L FI930220 L FI 930220L FI 930220 A FI930220 A FI 930220A FI 930220 A FI930220 A FI 930220A FI 930220 L FI930220 L FI 930220L
Authority
FI
Finland
Prior art keywords
analoger
oligonucleotide
deras framstaellning
framstaellning och
och anvaendning
Prior art date
Application number
FI930220A
Other languages
English (en)
Other versions
FI930220A0 (fi
FI115214B (fi
Inventor
Eugen Uhlmann
Anuschirwan Peyman
Gerard O'malley
Matthias Helsberg
Irvin Winkler
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI930220A0 publication Critical patent/FI930220A0/fi
Publication of FI930220L publication Critical patent/FI930220L/fi
Application granted granted Critical
Publication of FI115214B publication Critical patent/FI115214B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
FI930220A 1992-01-22 1993-01-20 Menetelmä oligonukleotidianalogien valmistamiseksi ja niiden käyttö FI115214B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4201662 1992-01-22
DE4201662 1992-01-22

Publications (3)

Publication Number Publication Date
FI930220A0 FI930220A0 (fi) 1993-01-20
FI930220L true FI930220L (fi) 1993-07-23
FI115214B FI115214B (fi) 2005-03-31

Family

ID=6450030

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930220A FI115214B (fi) 1992-01-22 1993-01-20 Menetelmä oligonukleotidianalogien valmistamiseksi ja niiden käyttö

Country Status (17)

Country Link
EP (1) EP0552766B1 (fi)
JP (1) JP3717081B2 (fi)
KR (1) KR930016437A (fi)
AT (1) ATE217880T1 (fi)
AU (1) AU661365B2 (fi)
CA (1) CA2087818C (fi)
DE (1) DE59310285D1 (fi)
DK (1) DK0552766T3 (fi)
ES (1) ES2177532T3 (fi)
FI (1) FI115214B (fi)
HU (1) HU227794B1 (fi)
IL (1) IL104461A (fi)
NO (1) NO308215B1 (fi)
NZ (1) NZ245720A (fi)
PL (1) PL172257B1 (fi)
PT (1) PT552766E (fi)
ZA (1) ZA93422B (fi)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378825A (en) * 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use
ATE151773T1 (de) * 1992-09-24 1997-05-15 Hoechst Ag Oligoribonucleotid- und ribozym-analoga mit terminalen 3'-3'-bzw.5'-5'-verknüpfungen
EP0602524A1 (de) * 1992-12-15 1994-06-22 Hoechst Aktiengesellschaft Chemilumineszenzmarkierte Gensonden und ihre Verwendung in Gensondentesten
US6087491A (en) * 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
JPH08507752A (ja) * 1993-01-08 1996-08-20 ハイブライドン インコーポレイテッド 二量体ブロックの合成と二量体ブロックを使ったオリゴヌクレオチド結合法
AU6165494A (en) * 1993-01-25 1994-08-15 Hybridon, Inc. Oligonucleotide alkylphosphonates and alkylphosphonothioates
CA2114355A1 (en) * 1993-01-29 1994-07-30 Hidehiko Furukawa Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
US5532130A (en) * 1993-07-20 1996-07-02 Dyad Pharmaceutical Corporation Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides
DE4331670A1 (de) * 1993-09-17 1995-03-23 Hoechst Ag Neue Antisense-Oligonucleotide gegen HSV-1 sowie deren Herstellung
DE4338704A1 (de) 1993-11-12 1995-05-18 Hoechst Ag Stabilisierte Oligonucleotide und deren Verwendung
US6919441B2 (en) 1994-03-14 2005-07-19 Aventis Pharma Deutschland Gmbh Polyamide-oligonucleotide derivatives, their preparation and use
DE4408528A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
US5726297A (en) * 1994-03-18 1998-03-10 Lynx Therapeutics, Inc. Oligodeoxyribonucleotide N3' P5' phosphoramidates
JP3482209B2 (ja) * 1994-03-18 2003-12-22 ジェロン・コーポレーション オリゴヌクレオチドｎ３’→ｐ５’ホスホルアミデート：合成および化合物；ハイブリダイゼーションおよびヌクレアーゼ耐性特性
US5599922A (en) * 1994-03-18 1997-02-04 Lynx Therapeutics, Inc. Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties
DE4415370A1 (de) * 1994-05-02 1995-11-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
US5986076A (en) * 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
US5696248A (en) * 1994-06-15 1997-12-09 Hoechst Aktiengesellschaft 3'-modified oligonucleotide derivatives
DE4438918A1 (de) * 1994-11-04 1996-05-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
US6150510A (en) 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
DE19502912A1 (de) * 1995-01-31 1996-08-01 Hoechst Ag G-Cap Stabilisierte Oligonucleotide
PT739898E (pt) * 1995-03-13 2002-03-28 Aventis Pharma Gmbh Mono-esteres de acidos fosfonucleicos processo para a sua preparacao e sua utilizacao
US6326487B1 (en) 1995-06-05 2001-12-04 Aventis Pharma Deutschland Gmbh 3 modified oligonucleotide derivatives
US5684143A (en) * 1996-02-21 1997-11-04 Lynx Therapeutics, Inc. Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
US5859233A (en) * 1996-02-21 1999-01-12 Lynx Therapeutics, Inc. Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
GB9606158D0 (en) * 1996-03-23 1996-05-29 Ciba Geigy Ag Chemical compounds
EP0808898B1 (en) * 1996-05-24 2004-05-19 Aventis Pharma Deutschland GmbH Reagent and method for inhibition of N-ras expression
DE19627898A1 (de) * 1996-07-11 1998-01-15 Hoechst Ag Festphasensynthese von Oligonucleotiden
CA2288946A1 (en) 1997-05-05 1998-11-12 Hoechst Marion Roussel Deutschland Gmbh Modified antisense nucleotides complementary to a section of the human ha-ras gene
AU9460898A (en) * 1997-10-14 1999-05-03 Sankyo Company Limited Modified oligodeoxyribonucleotides having tggg sequence
EP1004661A1 (de) 1998-11-11 2000-05-31 DALLI-WERKE WÄSCHE- und KÖRPERPFLEGE GmbH & Co. KG Verdichtetes Granulat, Herstellungsverfahren und Verwendung als Sprengmittel für gepresste Formkörper (2)
DE19935302A1 (de) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Konjugate und Verfahren zu deren Herstellung sowie deren Verwendung zum Transport von Molekülen über biologische Membranen
DE19935303A1 (de) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Oligonukleotide zur Inhibierung der Expression von humanem eg5
DE10133915A1 (de) 2001-07-12 2003-02-06 Aventis Pharma Gmbh Neue Oligoribonucleotid-Derivate zur gezielten Hemmung der Genexpression
NZ545360A (en) 2003-08-28 2009-06-26 Novartis Ag Interfering RNA duplex having blunt-ends and 3'-modifications
GB0608838D0 (en) 2006-05-04 2006-06-14 Novartis Ag Organic compounds
US10131904B2 (en) 2008-02-11 2018-11-20 Rxi Pharmaceuticals Corporation Modified RNAi polynucleotides and uses thereof
US8815818B2 (en) 2008-07-18 2014-08-26 Rxi Pharmaceuticals Corporation Phagocytic cell delivery of RNAI
US8796443B2 (en) 2008-09-22 2014-08-05 Rxi Pharmaceuticals Corporation Reduced size self-delivering RNAi compounds
WO2010059226A2 (en) 2008-11-19 2010-05-27 Rxi Pharmaceuticals Corporation Inhibition of map4k4 through rnai
WO2010090762A1 (en) 2009-02-04 2010-08-12 Rxi Pharmaceuticals Corporation Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
IL265674B2 (en) 2010-03-24 2024-05-01 Phio Pharm Corp Rana disorder in cutaneous and fibrotic symptoms
RU2615143C2 (ru) 2010-03-24 2017-04-04 Адвирна Самодоставляющие PHKi соединения уменьшенного размера
US9095504B2 (en) 2010-03-24 2015-08-04 Rxi Pharmaceuticals Corporation RNA interference in ocular indications
CN106061488B (zh) 2013-12-02 2021-04-09 菲奥医药公司 癌症的免疫治疗
WO2015125845A1 (ja) * 2014-02-20 2015-08-27 塩野義製薬株式会社 含窒素非芳香族複素環を含む核酸のリン酸部位修飾
CA2947270A1 (en) 2014-04-28 2015-11-05 Rxi Pharmaceuticals Corporation Methods for treating cancer using nucleic acids targeting mdm2 or mycn
KR102506169B1 (ko) 2014-09-05 2023-03-08 피오 파마슈티칼스 코프. Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법
US10808247B2 (en) 2015-07-06 2020-10-20 Phio Pharmaceuticals Corp. Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
KR20180026739A (ko) 2015-07-06 2018-03-13 알엑스아이 파마슈티칼스 코포레이션 슈퍼옥시드 디스뮤타제 1 (sod1)을 표적화하는 핵산 분자
US11021707B2 (en) 2015-10-19 2021-06-01 Phio Pharmaceuticals Corp. Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA
EP3612152A4 (en) 2017-04-19 2021-02-17 Phio Pharmaceuticals Corp. TOPICAL ADMINISTRATION OF NUCLEIC ACID COMPOUNDS
MX2020011570A (es) 2018-05-07 2020-11-24 Alnylam Pharmaceuticals Inc Administracion extrahepatica.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3239888A1 (de) * 1982-10-28 1984-05-03 Hubert Prof. Dr. 2000 Hamburg Köster Verfahren zur herstellung von oligonucleosidphosphonaten
US4739044A (en) * 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
US4950745A (en) * 1986-10-30 1990-08-21 Daicel Chemical Industries, Ltd. Process for synthesis of oligonucleotides and compound for forming polymeric protecting group
US4816571A (en) * 1987-06-04 1989-03-28 Applied Biosystems, Inc. Chemical capping by phosphitylation during oligonucleotide synthesis
EP0497875B1 (en) * 1989-10-24 2000-03-22 Isis Pharmaceuticals, Inc. 2' modified oligonucleotides
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
GB9021625D0 (en) * 1990-10-04 1990-11-21 Ici Plc Synthesis of oligonucleotides

Also Published As

Publication number Publication date
JP3717081B2 (ja) 2005-11-16
JPH05310779A (ja) 1993-11-22
DK0552766T3 (da) 2002-08-19
HUT63173A (en) 1993-07-28
NZ245720A (en) 1995-12-21
IL104461A (en) 2001-05-20
AU661365B2 (en) 1995-07-20
FI930220A0 (fi) 1993-01-20
AU3191093A (en) 1993-07-29
CA2087818C (en) 2007-07-10
DE59310285D1 (de) 2002-06-27
IL104461A0 (en) 1993-05-13
NO930199D0 (no) 1993-01-21
HU227794B1 (en) 2012-03-28
KR930016437A (ko) 1993-08-26
ES2177532T3 (es) 2002-12-16
PL297515A1 (en) 1993-09-06
EP0552766A3 (en) 1994-09-07
CA2087818A1 (en) 1993-07-23
FI115214B (fi) 2005-03-31
EP0552766A2 (de) 1993-07-28
PT552766E (pt) 2002-10-31
NO930199L (no) 1993-07-23
PL172257B1 (pl) 1997-08-29
ZA93422B (en) 1993-09-16
HU9300162D0 (en) 1993-04-28
NO308215B1 (no) 2000-08-14
ATE217880T1 (de) 2002-06-15
EP0552766B1 (de) 2002-05-22

Similar Documents

Publication Publication Date Title
FI930220L (fi) Oligonukleotidsanaloger, deras framstaellning och anvaendning
FI933857A7 (fi) Kondenserade heterocykliska foereningar, deras framstaellning och anvaendning
FI934274L (fi) N-sulfonyl-2-oxi-indolderivat, deras framstaellning och dessa innehaollande farmaceutiska kompositioner
FI931608L (fi) Foerfarande och anordning foer terapeutisk, elektromagnetisk behandling
FI931901L (fi) Azolfoereningar, deras framstaellning och anvaendning
FI931305A7 (fi) Imidazolfoereningar, deras framstaellning och bruk
FI933942L (fi) Cykliska ureaderivat, dessa foereningar innehaollande laekemedel och foerfarande foer deras framstaellning
FI930620A0 (fi) Bensimidazolylderivat, dessa foereningar innehaollande laekemedel och foerfarande foer deras framstaellning
FI931190A7 (fi) Triazolopyridazinfoereningar, deras framstaellning och anvaendning
FI930711L (fi) Naftalenderivat, foerfarande foer deras framstaellning och deras syntetiska mellanprodukter
FI932660L (fi) Vaermefoerseglingsbara, antistatiska belagda folier och folielaminat, foerfarande foer framstaellning av dessa och anvaendning av dessa
FI930977L (fi) Taxanderivat, deras framstaellning och onkologiska anvaendning
FI932649L (fi) Bifenylderivat, dessa foereningar innehaollande laekemedel och foerfarandefoer deras framstaellning
FI933903A7 (fi) Substituerade cyklohexanderivat, foerfarande foer framstaellning daerav och anvaendning av foereningar foer behandling av sjukdomar
FI930974L (fi) Substituerade aminofosfonatderivat, foerfarande foer framstaellning av desamma och farmaceutiska kompositioner innehaollande desamma
FI931291L (fi) Indol- och indazolderivat foer behandling och foerebyggande av hjaernsjukdomar, deras framstaellning och anvaendning
FI922004A0 (fi) Maetningsfoerfarande och maetanordning.
FI935829A0 (fi) Anlaeggning och foerfarande foer uttnyttjning av braennbara aemnen, speciellt industri- och hushaollsavfall
FI931599L (fi) Bensimidazoler, dessa foereningar innehaollande laekemedel och foerfarandefoer deras framstaellning
FI930130L (fi) Bundet fiberknippe, foerfarande foer framstaellning av detta och daerav erhaollna textilytstrukturer
FI930717A7 (fi) 4-amino-2-ureido-pyrimidin-5-karboxylsyraamider, foerfarande foer framstaellning av dessa, laekemedel innehaollande dessa och deras anvaendning
FI931682L (fi) Tackykininreceptorantagonister, isokinoloner och deras framstaellning
FI934221A0 (fi) Piperidinderivat, framstaellning och terapeutisk anvaendning daerav
FI932951L (fi) Tillsatskonsentrat innehaollande sulfurerat jordalkalimetallhydrokarbylfenat, foerfarande foer framstaellning av detta och anvaendning av detta
FI930236L (fi) Bensimidazoler, dessa foereningar innehaollande laekemedel och foerfarandefoer deras framstaellning

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 115214

Country of ref document: FI

MA Patent expired