FI960856L - Uudet retinoidit - Google Patents

Uudet retinoidit Download PDF

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Publication number
FI960856L
FI960856L FI960856A FI960856A FI960856L FI 960856 L FI960856 L FI 960856L FI 960856 A FI960856 A FI 960856A FI 960856 A FI960856 A FI 960856A FI 960856 L FI960856 L FI 960856L
Authority
FI
Finland
Prior art keywords
new retinoids
retinoids
new
Prior art date
Application number
FI960856A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI960856A7 (fi
FI960856A0 (fi
Inventor
Michael Klaus
Allen John Lovey
Peter Mohr
Michael Rosenberger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI960856A0 publication Critical patent/FI960856A0/fi
Publication of FI960856A7 publication Critical patent/FI960856A7/fi
Publication of FI960856L publication Critical patent/FI960856L/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/38Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/45Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings having unsaturation outside the rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/548Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings having unsaturation outside the six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09Geometrical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Vapour Deposition (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Cosmetics (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
FI960856A 1995-02-24 1996-02-23 Uudet retinoidit FI960856L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39398095A 1995-02-24 1995-02-24
US46828995A 1995-06-06 1995-06-06

Publications (3)

Publication Number Publication Date
FI960856A0 FI960856A0 (fi) 1996-02-23
FI960856A7 FI960856A7 (fi) 1996-08-25
FI960856L true FI960856L (fi) 1996-08-25

Family

ID=27014530

Family Applications (1)

Application Number Title Priority Date Filing Date
FI960856A FI960856L (fi) 1995-02-24 1996-02-23 Uudet retinoidit

Country Status (23)

Country Link
US (1) US5986131A (cs)
EP (1) EP0728742B1 (cs)
JP (1) JP2776787B2 (cs)
KR (1) KR100414342B1 (cs)
CN (1) CN1124260C (cs)
AT (1) ATE185799T1 (cs)
AU (1) AU703115B2 (cs)
CA (1) CA2170227A1 (cs)
CZ (1) CZ291352B6 (cs)
DE (1) DE69604713T2 (cs)
DK (1) DK0728742T3 (cs)
ES (1) ES2138765T3 (cs)
FI (1) FI960856L (cs)
GR (1) GR3032407T3 (cs)
HU (1) HU219538B (cs)
IL (1) IL117170A (cs)
MA (1) MA23813A1 (cs)
MY (1) MY113430A (cs)
NO (1) NO309189B1 (cs)
NZ (1) NZ286017A (cs)
RU (1) RU2166499C2 (cs)
SG (1) SG59945A1 (cs)
TW (1) TW343966B (cs)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1511519A (zh) 1997-11-12 2004-07-14 - 2型t辅助细胞介导的免疫病的治疗
US6326397B1 (en) 1998-11-10 2001-12-04 Hoffman-La Roche Inc. Retinoid antagonists and use thereof
JO2178B1 (en) * 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of emphysema using rar selective retinoid antagonists
JP4543513B2 (ja) * 2000-07-17 2010-09-15 ソニー株式会社 双方向通信システム、表示装置、ベース装置および双方向通信方法
EP1935869A1 (en) 2000-10-02 2008-06-25 F. Hoffmann-La Roche Ag Retinoids for the treatment of emphysema
US6495719B2 (en) 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7842727B2 (en) 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
WO2003099272A1 (en) 2002-05-22 2003-12-04 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
JP2006508986A (ja) 2002-11-20 2006-03-16 エルラント ゲネ セラペウチクス エルエルシー ヒストンデアセチラーゼ阻害剤による肺細胞の治療方法
RU2223751C1 (ru) * 2003-01-08 2004-02-20 Козлович Аркадий Викторович Лекарственное средство для лечения ожогов
RU2225202C1 (ru) * 2003-02-28 2004-03-10 Бородкина Татьяна Владимировна Гель гигиенический
RU2275907C2 (ru) * 2004-07-12 2006-05-10 Наталия Анатольевна Полонская Способ лечения угревой болезни
EP1621191A1 (en) * 2004-07-29 2006-02-01 Werner Bollag Treatment of inflammatory diseases by RXR Antagonists
EP1771163A1 (en) * 2004-07-29 2007-04-11 Werner Bollag Rxr antagonist treatment against multiple sclerosis
CA2622600A1 (en) * 2005-10-25 2007-05-03 Werner Bollag Rxr agonists and antagonists, alone or in combination with ppar ligands, in the treatment of metabolic and cardiovascular diseases
CN105646311B (zh) * 2016-03-31 2017-09-26 广州巨元生化有限公司 一种制备β‑阿朴‑8’‑胡萝卜醛的方法
EP3301085A1 (en) * 2016-09-29 2018-04-04 Biogem S.Ca.R.L. Retinoid derivatives with antitumor activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3277147A (en) * 1963-06-05 1966-10-04 Olin Mathieson Lower alkyl esters of beta-cyclocitrylidene fluoroacetic acid and beta-ionylidene fluoroacetic acid
US5514672A (en) * 1981-02-17 1996-05-07 Bazzano; Gail S. Use of retinoids and compositions containing same for hair growth
DE69324043T2 (de) * 1993-01-11 1999-07-01 Ligand Pharmaceuticals, Inc., San Diego, Calif. Verbindungen mit selektiver wirkung fuer retinoid x rezeptoren, und mittel fuer steuerung fuer durch retinoid x rezeptoren bedingte prozesse
IL116259A (en) * 1994-12-19 2000-07-16 American Cyanamid Co Analogs of 9-cis retinoic acid and their use

Also Published As

Publication number Publication date
CZ53796A3 (en) 1996-11-13
GR3032407T3 (en) 2000-05-31
DE69604713T2 (de) 2000-06-21
MA23813A1 (fr) 1996-10-01
RU2166499C2 (ru) 2001-05-10
FI960856A7 (fi) 1996-08-25
CN1136557A (zh) 1996-11-27
NO960751L (no) 1996-08-26
TW343966B (en) 1998-11-01
HU9600424D0 (en) 1996-04-29
FI960856A0 (fi) 1996-02-23
CA2170227A1 (en) 1996-08-25
EP0728742A3 (en) 1996-10-23
HUP9600424A2 (en) 1996-12-30
AU703115B2 (en) 1999-03-18
HUP9600424A3 (en) 1998-04-28
NO309189B1 (no) 2000-12-27
CZ291352B6 (cs) 2003-02-12
KR100414342B1 (ko) 2004-05-10
CN1124260C (zh) 2003-10-15
DK0728742T3 (da) 2000-04-17
AU4561796A (en) 1996-09-05
NZ286017A (en) 1997-12-19
ES2138765T3 (es) 2000-01-16
SG59945A1 (en) 1999-02-22
KR960031422A (ko) 1996-09-17
EP0728742B1 (en) 1999-10-20
NO960751D0 (no) 1996-02-23
MY113430A (en) 2002-02-28
HU219538B (hu) 2001-05-28
US5986131A (en) 1999-11-16
DE69604713D1 (de) 1999-11-25
IL117170A (en) 2000-11-21
ATE185799T1 (de) 1999-11-15
JPH08259527A (ja) 1996-10-08
EP0728742A2 (en) 1996-08-28
JP2776787B2 (ja) 1998-07-16
IL117170A0 (en) 1996-06-18
HK1012330A1 (en) 1999-07-30

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