FR18C1038I2 - Procede de production et de purification d'alpha-mannosidase lysosomale recombinante - Google Patents

Procede de production et de purification d'alpha-mannosidase lysosomale recombinante

Info

Publication number
FR18C1038I2
FR18C1038I2 FR18C1038C FR18C1038C FR18C1038I2 FR 18C1038 I2 FR18C1038 I2 FR 18C1038I2 FR 18C1038 C FR18C1038 C FR 18C1038C FR 18C1038 C FR18C1038 C FR 18C1038C FR 18C1038 I2 FR18C1038 I2 FR 18C1038I2
Authority
FR
France
Prior art keywords
mannosidase
purification
production
recombinant lysosomal
lysosomal alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR18C1038C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Publication of FR18C1038I1 publication Critical patent/FR18C1038I1/fr
Application granted granted Critical
Publication of FR18C1038I2 publication Critical patent/FR18C1038I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477—Hemicellulases not provided in a preceding group
    • C12N9/2488—Mannanases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01024—Alpha-mannosidase (3.2.1.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
FR18C1038C 2010-02-24 2018-09-14 Procede de production et de purification d'alpha-mannosidase lysosomale recombinante Active FR18C1038I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30758710P 2010-02-24 2010-02-24
DKPA201070067 2010-02-24
PCT/DK2011/050054 WO2011103877A1 (fr) 2010-02-24 2011-02-23 Procédé de production et de purification d'alpha-mannosidase lysosomale recombinante

Publications (2)

Publication Number Publication Date
FR18C1038I1 FR18C1038I1 (fr) 2018-11-02
FR18C1038I2 true FR18C1038I2 (fr) 2019-10-11

Family

ID=43920349

Family Applications (1)

Application Number Title Priority Date Filing Date
FR18C1038C Active FR18C1038I2 (fr) 2010-02-24 2018-09-14 Procede de production et de purification d'alpha-mannosidase lysosomale recombinante

Country Status (24)

Country Link
US (3) US8974780B2 (fr)
EP (2) EP3281636B1 (fr)
JP (1) JP6021647B2 (fr)
KR (1) KR101856260B1 (fr)
CN (1) CN102834111B (fr)
AU (1) AU2011220163B2 (fr)
BR (1) BR112012020934B1 (fr)
CA (1) CA2790786C (fr)
CY (2) CY1123438T1 (fr)
DK (2) DK3281636T3 (fr)
EA (1) EA022220B1 (fr)
ES (1) ES2652330T3 (fr)
FR (1) FR18C1038I2 (fr)
HR (1) HRP20171736T1 (fr)
HU (2) HUE037943T2 (fr)
LT (2) LT2538968T (fr)
NL (1) NL300948I2 (fr)
NO (2) NO2538968T3 (fr)
NZ (1) NZ601790A (fr)
PL (2) PL2538968T3 (fr)
PT (1) PT2538968T (fr)
RS (1) RS60983B1 (fr)
SI (2) SI2538968T1 (fr)
WO (1) WO2011103877A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9310344B2 (en) 2013-06-14 2016-04-12 Dionex Corporation HILIC/anion-exchange/cation-exchange multimodal media
US9169331B2 (en) 2012-12-21 2015-10-27 Dionex Corporation Separation of glycans by mixed-mode liquid chromatography
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
AU2016329034B2 (en) * 2015-09-22 2019-05-23 Pfizer Inc. Method of preparing a therapeutic protein formulation and antibody formulation produced by such a method
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
CN111100196B (zh) * 2019-11-08 2021-07-13 上海交通大学 一种生物活性多肽qilsvpgwtysr及其制备方法和应用
WO2024233992A2 (fr) * 2023-05-11 2024-11-14 Trophogen, Inc. Procédés de fabrication d'hormones de glycoprotéine hautement glycosylées et leurs analogues

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL63327A (en) * 1981-07-16 1985-11-29 Yeda Res & Dev Production of interferon beta1 and alpha-phage recombinants for its production in host bacteria
US5705364A (en) * 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
JP4320870B2 (ja) 1999-10-18 2009-08-26 住友化学株式会社 （＋）−トランス第一菊酸の製造方法
GB0007651D0 (en) * 2000-03-29 2000-05-17 Ascorbex Ltd Gene sequence
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
WO2002099092A2 (fr) * 2001-06-07 2002-12-12 Hemebiotech A/S Production de l'alpha-mannosidase lysosomique humaine recombinee
JP4742191B2 (ja) * 2001-06-14 2011-08-10 独立行政法人産業技術総合研究所 糖蛋白質およびその製造方法
US7507573B2 (en) * 2003-11-14 2009-03-24 Vib, Vzw Modification of protein glycosylation in methylotrophic yeast
JP4586027B2 (ja) * 2004-01-30 2010-11-24 シャイア ファーマシューティカルズ アイルランド リミテッド 組換えアリールスルファターゼａの製造及び精製
AU2005211775B2 (en) * 2004-02-06 2009-10-08 Biomarin Pharmaceutical Inc. Manufacture of highly phosphorylated lysosomal enzymes and uses thereof
WO2005094874A1 (fr) * 2004-04-01 2005-10-13 Zymenex A/S Utilisation medicale de l'alpha-mannosidase
CN101410408A (zh) 2006-04-04 2009-04-15 希尔制药爱尔兰有限责任公司 用于浓缩多肽的方法
MX2008012748A (es) 2006-04-04 2009-01-07 Shire Pharmaceuticals Ireland Un proceso para la concentracion de un polipeptido.
WO2009007451A1 (fr) * 2007-07-11 2009-01-15 Novo Nordisk A/S Purification du facteur viii à l'aide d'une résine en mode mixte ou multimodal

Also Published As

Publication number Publication date
AU2011220163B2 (en) 2015-05-28
RS60983B1 (sr) 2020-11-30
AU2011220163A1 (en) 2012-08-30
SI3281636T1 (sl) 2020-11-30
BR112012020934A2 (pt) 2017-02-21
NO2018032I1 (no) 2018-09-14
JP6021647B2 (ja) 2016-11-09
PT2538968T (pt) 2018-01-23
WO2011103877A1 (fr) 2011-09-01
CA2790786A1 (fr) 2011-09-01
EA201270715A1 (ru) 2013-01-30
CY1123438T1 (el) 2021-05-05
KR101856260B1 (ko) 2018-05-09
EP2538968B1 (fr) 2017-11-01
LTPA2018512I1 (lt) 2018-10-10
NO2538968T3 (fr) 2018-03-31
PL2538968T3 (pl) 2018-04-30
EP3281636B1 (fr) 2020-08-05
CN102834111B (zh) 2014-11-12
EA022220B1 (ru) 2015-11-30
FR18C1038I1 (fr) 2018-11-02
CN102834111A (zh) 2012-12-19
US8974780B2 (en) 2015-03-10
HUS1800037I1 (hu) 2018-09-28
ES2652330T3 (es) 2018-02-01
HUE037943T2 (hu) 2018-09-28
US20120308549A1 (en) 2012-12-06
EP3281636A1 (fr) 2018-02-14
LTC2538968I2 (lt) 2019-11-11
CA2790786C (fr) 2019-09-24
US20150306186A1 (en) 2015-10-29
BR112012020934B1 (pt) 2021-07-13
KR20120128647A (ko) 2012-11-27
PL3281636T3 (pl) 2021-03-08
DK3281636T3 (da) 2020-09-21
HRP20171736T1 (hr) 2018-01-26
HK1179869A1 (en) 2013-10-11
LT2538968T (lt) 2018-01-10
JP2013520184A (ja) 2013-06-06
NZ601790A (en) 2014-03-28
EP2538968A1 (fr) 2013-01-02
DK2538968T3 (en) 2017-12-11
US20180036387A1 (en) 2018-02-08
CY2021002I1 (el) 2021-05-05
BR112012020934A8 (pt) 2018-02-06
NL300948I2 (nl) 2019-02-27
US10159718B2 (en) 2018-12-25
SI2538968T1 (en) 2018-04-30

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