FR2108456A5 - Antibacterial azetidin-2-ones - prepd from related sulphonoxy cpds and nucleophiles - Google Patents

Antibacterial azetidin-2-ones - prepd from related sulphonoxy cpds and nucleophiles

Info

Publication number: FR2108456A5
Authority: FR; France
Prior art keywords: alkyl; opt; substd; alkoxy; benzyl
Prior art date: 1970-09-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

FR7134243A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hoechst AG

Original Assignee

Hoechst AG

Farbwerke Hoechst AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1970-09-23

Filing date

1971-09-23

Publication date

1972-05-19

1971-09-23 Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG

1972-05-19 Application granted granted Critical

1972-05-19 Publication of FR2108456A5 publication Critical patent/FR2108456A5/fr

Status Expired legal-status Critical Current

Links

230000000844 anti-bacterial effect Effects 0.000 title 1
MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title 1
239000012038 nucleophile Substances 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 4
-1 sulphamoyl Chemical group 0.000 abstract 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
229910052794 bromium Inorganic materials 0.000 abstract 3
229910052801 chlorine Inorganic materials 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
125000004428 fluoroalkoxy group Chemical group 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000005035 acylthio group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000005108 alkenylthio group Chemical group 0.000 abstract 1
125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
125000005093 alkyl carbonyl alkyl group Chemical group 0.000 abstract 1
125000005109 alkynylthio group Chemical group 0.000 abstract 1
125000005097 aminocarbonylalkyl group Chemical group 0.000 abstract 1
239000000010 aprotic solvent Substances 0.000 abstract 1
125000005110 aryl thio group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
125000004967 formylalkyl group Chemical group 0.000 abstract 1
125000000262 haloalkenyl group Chemical group 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FR7134243A 1970-09-23 1971-09-23 Antibacterial azetidin-2-ones - prepd from related sulphonoxy cpds and nucleophiles Expired FR2108456A5 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19702046822 DE2046822A1 (de)	1970-09-23	1970-09-23	Neue Azetidinone-(2) und Verfahren zu deren Herstellung

Publications (1)

Publication Number	Publication Date
FR2108456A5 true FR2108456A5 (en)	1972-05-19

Family

ID=5783147

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR7134243A Expired FR2108456A5 (en)	1970-09-23	1971-09-23	Antibacterial azetidin-2-ones - prepd from related sulphonoxy cpds and nucleophiles

Country Status (5)

Country	Link
AT (1)	AT313912B (fr)
BE (1)	BE772990A (fr)
DE (1)	DE2046822A1 (fr)
FR (1)	FR2108456A5 (fr)
NL (1)	NL7112824A (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4162250A (en) *	1976-09-08	1979-07-24	Smithkline Corporation	3-Aminoazetidinone derivatives
JPS56125360A (en) *	1980-03-07	1981-10-01	Sagami Chem Res Center	Beta-lactam compound
US4680391A (en) *	1983-12-01	1987-07-14	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229510A (en) *	1983-12-01	1993-07-20	Merck & Co., Inc.	β-lactams useful in determining the amount of elastase in a clinical sample
US5229381A (en) *	1983-12-01	1993-07-20	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5104862A (en) *	1991-03-20	1992-04-14	Merck & Co., Inc.	Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5100880A (en) *	1991-03-20	1992-03-31	Merck & Co., Inc.	Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5348953A (en) *	1991-06-25	1994-09-20	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
CA2147129A1 (fr) *	1992-10-27	1994-05-11	James B. Doherty	Nouvelles azetidinones substituees utilisees comme agents anti-inflammatoires et anti-degeneratifs
US5591737A (en) *	1992-12-17	1997-01-07	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5747485A (en) *	1995-04-13	1998-05-05	Merck & Co., Inc.	Substituted azetidiones as anti-inflammatory and antidegenerative agents

1970
- 1970-09-23 DE DE19702046822 patent/DE2046822A1/de active Pending
1971
- 1971-09-17 NL NL7112824A patent/NL7112824A/xx unknown
- 1971-09-22 AT AT821771A patent/AT313912B/de not_active IP Right Cessation
- 1971-09-23 FR FR7134243A patent/FR2108456A5/fr not_active Expired
- 1971-09-23 BE BE772990A patent/BE772990A/fr unknown

Also Published As

Publication number	Publication date
AT313912B (de)	1974-03-11
DE2046822A1 (de)	1972-03-30
NL7112824A (fr)	1972-03-27
BE772990A (fr)	1972-03-23

Legal Events

Date	Code	Title	Description
1975-11-14	ST	Notification of lapse

Publication	Publication Date	Title
FR2108457A5 (en)	1972-05-19	Antibacterial azetidin-2-one derivs - prepd by ozonolysis of other derivs contg unsatd gps
GB1412886A (en)	1975-11-05	Penicillin and cephalosporin compounds
FR2337554A1 (fr)	1977-08-05	Nouveaux derives de la pyrazolidinedione
SE8305009D0 (sv)	1983-09-19	Sett att framstella antibakteriella amidforeningar
ES463737A1 (es)	1979-01-01	Metodo para producir cefalosporinas y similares
US4505894A (en)	1985-03-19	Therapeutic compounds containing β-lactams
ES420869A1 (es)	1976-04-01	Un procedimiento para la preparacion de alfa-aminoacilcefa-losporinas.
FR2108458A5 (en)	1972-05-19	Antibacterial azetidin-2-ones - from schiff bases and substd-acetyl halides
EP0061313A3 (en)	1982-12-08	Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics
ES8100278A1 (es)	1980-11-01	Un procedimiento para la preparacion de derivados de 5-triazina
FR2148362A1 (en)	1973-03-23	2-amino-(4,5-b)-oxazolopyridine cpds - with analgesic,anti-inflammato anticonvulsant,muscle relaxant and diuretic activity
IE33571L (en)	1970-02-23	Preparation of cephalosporins
GB1074331A (en)	1967-07-05	Penicillins
ES389076A1 (es)	1974-04-01	Un metodo para la preparacion de 6-(d-alfa-amino -p- hidro-xifenilacetamido) penicilanato sodico o potasico.
SE7702370L (sv)	1977-09-17	Tienamycinderivat
IE34651L (en)	1971-04-28	Heterocyclic compounds.
GR75654B (fr)	1984-08-02
GB1138745A (en)	1969-01-01	Penicillins
SE7702558L (sv)	1977-09-09	Forfarande for framstellning av cefalosporiner
GB1141621A (en)	1969-01-29	Penicillins
FR2177252A5 (en)	1973-11-02	Cyanoalkoxy carbonylthio acetonitriles - insecticides and fungicides
NL7314205A (en)	1973-12-27	Substd thenyl chrysanthemate - insecticides
FR2253504A2 (en)	1975-07-04	1-(3,4-Methylenedioxyphenyl)-4,4-dimethyl-pent-1-en-3-ol esters - modifiers of hexobarbital narcosis
FR2091450A5 (en)	1972-01-14	O-ethyl-5n-propyl-5-alkyl-or aryl thiomethyl phosphorodithiolates - pesticides
FR2210383A1 (en)	1974-07-12	Alpha aldimino-penicillins prepn. - from an amino penicillin and 5-nitro furfural or 5-nitro thien aldehyde