FR2244459A1 - 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics - Google Patents

2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics

Info

Publication number: FR2244459A1
Authority: FR; France
Prior art keywords: alkyl; broncho; vasodilating; sedatives; diuretics
Prior art date: 1973-09-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

FR7333831A

Other languages

English (en)

Other versions

FR2244459B1 (fr

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Synthelabo SA

Original Assignee

Delalande SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-09-20

Filing date

1973-09-20

Publication date

1975-04-18

1973-09-20 Application filed by Delalande SA filed Critical Delalande SA

1973-09-20 Priority to FR7333831A priority Critical patent/FR2244459A1/fr

1974-08-21 Priority to BE147794A priority patent/BE819057A/fr

1974-08-21 Priority to CH1140174A priority patent/CH593266A5/xx

1974-08-23 Priority to LU70791A priority patent/LU70791A1/xx

1974-08-28 Priority to GB3755074A priority patent/GB1430729A/en

1974-09-03 Priority to US05/502,285 priority patent/US3978055A/en

1974-09-07 Priority to ES429869A priority patent/ES429869A1/es

1974-09-10 Priority to ZA00745741A priority patent/ZA745741B/xx

1974-09-13 Priority to JP49105900A priority patent/JPS5088079A/ja

1974-09-17 Priority to DE19742444426 priority patent/DE2444426A1/de

1974-09-18 Priority to CA209,631A priority patent/CA1008074A/fr

1974-09-18 Priority to AU73441/74A priority patent/AU483869B2/en

1974-09-19 Priority to SU742062977A priority patent/SU645569A3/ru

1974-09-19 Priority to SE7411806A priority patent/SE410600B/xx

1974-09-19 Priority to IT69833/74A priority patent/IT1062796B/it

1974-09-20 Priority to NL7412494A priority patent/NL7412494A/xx

1975-04-18 Publication of FR2244459A1 publication Critical patent/FR2244459A1/fr

1976-08-16 Priority to US05/714,472 priority patent/US4025514A/en

1976-08-16 Priority to US05/714,473 priority patent/US4041030A/en

1977-09-02 Application granted granted Critical

1977-09-02 Publication of FR2244459B1 publication Critical patent/FR2244459B1/fr

1977-12-28 Priority to SU772558803A priority patent/SU698531A3/ru

Status Granted legal-status Critical Current

Links

230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
230000000767 anti-ulcer Effects 0.000 title abstract 2
239000002934 diuretic Substances 0.000 title abstract 2
229940030606 diuretics Drugs 0.000 title abstract 2
229940125723 sedative agent Drugs 0.000 title abstract 2
239000000932 sedative agent Substances 0.000 title abstract 2
230000000304 vasodilatating effect Effects 0.000 title abstract 2
230000001078 anti-cholinergic effect Effects 0.000 title 1
239000004044 bronchoconstricting agent Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
-1 pyrrolidino, morpholino, piperidino Chemical group 0.000 abstract 6
229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
239000000812 cholinergic antagonist Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000006237 oxymethylenoxy group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

FR7333831A 1973-09-20 1973-09-20 2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics Granted FR2244459A1 (en)

Priority Applications (19)

Application Number	Priority Date	Filing Date	Title
FR7333831A FR2244459A1 (en)	1973-09-20	1973-09-20	2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics
BE147794A BE819057A (fr)	1973-09-20	1974-08-21	Nouveaux derives arylamino pyrimidiniques
CH1140174A CH593266A5 (fr)	1973-09-20	1974-08-21
LU70791A LU70791A1 (fr)	1973-09-20	1974-08-23
GB3755074A GB1430729A (en)	1973-09-20	1974-08-28	Arylamino pyrimidinic derivatives their process ff preparation and their therapeutic application
US05/502,285 US3978055A (en)	1973-09-20	1974-09-03	Arylamino pyrimidinic derivatives
ES429869A ES429869A1 (es)	1973-09-20	1974-09-07	Procedimiento de preparacion de derivados arilamino-pirimi-dinicos.
ZA00745741A ZA745741B (en)	1973-09-20	1974-09-10	Novel arylamino pyrimidinic derivatives
JP49105900A JPS5088079A (fr)	1973-09-20	1974-09-13
DE19742444426 DE2444426A1 (de)	1973-09-20	1974-09-17	Arylaminopyrimidinverbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
CA209,631A CA1008074A (fr)	1973-09-20	1974-09-18	Derives arylamino pyrimidiniques, leur procede de preparation et leur application en therapeutique
AU73441/74A AU483869B2 (en)	1973-09-20	1974-09-18	Novel arylamino pyrimidinic derivatives their process of preparation and their therapeutic application
SU742062977A SU645569A3 (ru)	1973-09-20	1974-09-19	Способ получени производных 4-ариламино-6-метилпиримидина
SE7411806A SE410600B (sv)	1973-09-20	1974-09-19	Sett att framstella nya arylaminopyrimidinderivat
IT69833/74A IT1062796B (it)	1973-09-20	1974-09-19	Derivati arilamino pirimidinici,loro procedimento di preparazione e loro applicazione in terapia
NL7412494A NL7412494A (nl)	1973-09-20	1974-09-20	Werkwijze voor de bereiding van nieuwe aryl- aminopyrimidineverbindingen.
US05/714,472 US4025514A (en)	1973-09-20	1976-08-16	Arylamino pyrimidinic derivatives
US05/714,473 US4041030A (en)	1973-09-20	1976-08-16	Arylamino pyrimidinic derivatives
SU772558803A SU698531A3 (ru)	1973-09-20	1977-12-28	Способ получени производных 4-ариламино-6-метилпиримидина

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR7333831A FR2244459A1 (en)	1973-09-20	1973-09-20	2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics

Publications (2)

Publication Number	Publication Date
FR2244459A1 true FR2244459A1 (en)	1975-04-18
FR2244459B1 FR2244459B1 (fr)	1977-09-02

Family

ID=9125341

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR7333831A Granted FR2244459A1 (en)	1973-09-20	1973-09-20	2-Arylamino-pyrimidines - useful as sedatives, antiinflammatory, anti-ulcer, vasodilating, anticholinergic and anti-broncho- constricting agents and diuretics

Country Status (4)

Country	Link
BE (1)	BE819057A (fr)
FR (1)	FR2244459A1 (fr)
SU (1)	SU698531A3 (fr)
ZA (1)	ZA745741B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2357252A2 (fr) *	1976-07-07	1978-02-03	Delalande Sa	Nouveaux derives arylaminopyrimidiniques, leur procede de preparation et leur application en therapeutique
EP1549316A4 (fr) *	2002-09-10	2008-04-09	Scios Inc	Inhibiteurs de tgf-$g(b)
WO2017068070A1 (fr) *	2015-10-20	2017-04-27	Vassilatis Demetrios K	Composés activant nurr1:rxr pour le traitement simultané des symptômes et de la pathologie de la maladie de parkinson

1973
- 1973-09-20 FR FR7333831A patent/FR2244459A1/fr active Granted
1974
- 1974-08-21 BE BE147794A patent/BE819057A/fr unknown
- 1974-09-10 ZA ZA00745741A patent/ZA745741B/xx unknown
1977
- 1977-12-28 SU SU772558803A patent/SU698531A3/ru active

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2357252A2 (fr) *	1976-07-07	1978-02-03	Delalande Sa	Nouveaux derives arylaminopyrimidiniques, leur procede de preparation et leur application en therapeutique
EP1549316A4 (fr) *	2002-09-10	2008-04-09	Scios Inc	Inhibiteurs de tgf-$g(b)
WO2017068070A1 (fr) *	2015-10-20	2017-04-27	Vassilatis Demetrios K	Composés activant nurr1:rxr pour le traitement simultané des symptômes et de la pathologie de la maladie de parkinson
LU92852B1 (en) *	2015-10-20	2017-05-02	Athanasios Spathis	NURR1:RXR activating compounds for simultaneous treatment of symptoms and pathology of Parkinsons disease
US10946019B2 (en)	2015-10-20	2021-03-16	Vassilatis Demetrios K	Nurr1:RXR activating compounds for simultaneous treatment of symptoms and pathology of Parkinson's disease

Also Published As

Publication number	Publication date
SU698531A3 (ru)	1979-11-15
FR2244459B1 (fr)	1977-09-02
BE819057A (fr)	1975-02-21
ZA745741B (en)	1975-10-29

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Legal Events

Date	Code	Title	Description
1981-07-31	ST	Notification of lapse