FR2273009A1 - 1-(L-(-)-gamma-amino-alpha-hydroxybutyryl)-kanamycine A prepn - by selective acylation with an N-hydroxy-norbornene-2,3-dicarboximide ester - Google Patents

1-(L-(-)-gamma-amino-alpha-hydroxybutyryl)-kanamycine A prepn - by selective acylation with an N-hydroxy-norbornene-2,3-dicarboximide ester

Info

Publication number: FR2273009A1
Authority: FR; France
Prior art keywords: kanamycine; gamma; alpha; norbornene; hydroxy
Prior art date: 1974-05-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

FR7512552A

Other languages

English (en)

French (fr)

Other versions

FR2273009B1 (de

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Co

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-05-23

Filing date

1975-04-22

Publication date

1975-12-26

1975-04-22 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1975-12-26 Publication of FR2273009A1 publication Critical patent/FR2273009A1/fr

1978-09-22 Application granted granted Critical

1978-09-22 Publication of FR2273009B1 publication Critical patent/FR2273009B1/fr

Status Granted legal-status Critical Current

Links

-1 N-hydroxy-norbornene-2,3-dicarboximide ester Chemical class 0.000 title abstract 2
230000010933 acylation Effects 0.000 title 1
238000005917 acylation reaction Methods 0.000 title 1
ULKOBRDRCYROKY-JTQLQIEISA-N (2s)-2-hydroxy-4-(phenylmethoxycarbonylamino)butanoic acid Chemical compound OC(=O)[C@@H](O)CCNC(=O)OCC1=CC=CC=C1 ULKOBRDRCYROKY-JTQLQIEISA-N 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

FR7512552A 1974-05-23 1975-04-22 1-(L-(-)-gamma-amino-alpha-hydroxybutyryl)-kanamycine A prepn - by selective acylation with an N-hydroxy-norbornene-2,3-dicarboximide ester Granted FR2273009A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US47278074A	1974-05-23	1974-05-23

Publications (2)

Publication Number	Publication Date
FR2273009A1 true FR2273009A1 (en)	1975-12-26
FR2273009B1 FR2273009B1 (de)	1978-09-22

Family

ID=23876917

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR7512552A Granted FR2273009A1 (en)	1974-05-23	1975-04-22	1-(L-(-)-gamma-amino-alpha-hydroxybutyryl)-kanamycine A prepn - by selective acylation with an N-hydroxy-norbornene-2,3-dicarboximide ester

Country Status (9)

Country	Link
AR (1)	AR205114A1 (de)
AT (1)	AT339478B (de)
BE (1)	BE828192A (de)
CS (1)	CS212755B2 (de)
DE (1)	DE2514817C2 (de)
FR (1)	FR2273009A1 (de)
IL (1)	IL46995A (de)
PL (1)	PL102734B1 (de)
SU (1)	SU1190988A3 (de)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5025442B2 (de) *	1972-03-14	1975-08-23

1975
- 1975-01-01 AR AR258166A patent/AR205114A1/es active
- 1975-03-28 AT AT243175A patent/AT339478B/de active
- 1975-04-01 IL IL46995A patent/IL46995A/en unknown
- 1975-04-04 DE DE2514817A patent/DE2514817C2/de not_active Expired
- 1975-04-17 CS CS752681A patent/CS212755B2/cs unknown
- 1975-04-21 BE BE155621A patent/BE828192A/xx not_active IP Right Cessation
- 1975-04-22 FR FR7512552A patent/FR2273009A1/fr active Granted
- 1975-05-22 PL PL1975180591A patent/PL102734B1/pl unknown
- 1975-05-22 SU SU752137425A patent/SU1190988A3/ru active

Also Published As

Publication number	Publication date
AT339478B (de)	1977-10-25
CS212755B2 (en)	1982-03-26
DE2514817C2 (de)	1982-06-16
DE2514817A1 (de)	1975-12-04
PL102734B1 (pl)	1979-04-30
BE828192A (fr)	1975-10-21
ATA243175A (de)	1977-02-15
IL46995A0 (en)	1975-06-25
AR205114A1 (es)	1976-04-05
SU1190988A3 (ru)	1985-11-07
FR2273009B1 (de)	1978-09-22
IL46995A (en)	1977-12-30

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