FR2276830A1 - Fractionating non-voltatile solids by partial precipitation - esp for recovering condensed tannins having circulatory activity from cypress berries - Google Patents
Fractionating non-voltatile solids by partial precipitation - esp for recovering condensed tannins having circulatory activity from cypress berriesInfo
- Publication number
- FR2276830A1 FR2276830A1 FR7422898A FR7422898A FR2276830A1 FR 2276830 A1 FR2276830 A1 FR 2276830A1 FR 7422898 A FR7422898 A FR 7422898A FR 7422898 A FR7422898 A FR 7422898A FR 2276830 A1 FR2276830 A1 FR 2276830A1
- Authority
- FR
- France
- Prior art keywords
- pptate
- pref
- fractionating
- esp
- solids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000218691 Cupressaceae Species 0.000 title abstract 2
- 229920002770 condensed tannin Polymers 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title abstract 2
- 235000021028 berry Nutrition 0.000 title 1
- 238000001556 precipitation Methods 0.000 title 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 229920001864 tannin Polymers 0.000 abstract 2
- 239000001648 tannin Substances 0.000 abstract 2
- 235000018553 tannin Nutrition 0.000 abstract 2
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 abstract 1
- 206010042618 Surgical procedure repeated Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000004856 capillary permeability Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000009109 curative therapy Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 abstract 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 abstract 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 abstract 1
- 235000005493 rutin Nutrition 0.000 abstract 1
- 229960004555 rutoside Drugs 0.000 abstract 1
- 239000005526 vasoconstrictor agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Method for fractionating mixts. contg. >=2 solids of low volatility by dissolving the mixt. in a first solvent (I) to a predetermined concn. (c), then adding a second solvent (II) able to modify solubility of the components aso as to cause pptation, and set up and equilibrium (E1) between dissolved matl. (S1) and pptate. (P1) is improved when (i) P1 is redissolved in (I), pref. at concn. C, then same amt. of (II) added to establish a second equilibrium, and procedure repeated to give finally a pptate; Pm, strongly enriched in the least soluble component, and solute Sm; and (ii) S1 is conc. by evaporation, pref. to conc. C, then (II) added to the concentrate (pref. same amt. as used initially) to establish a new equilibrium between solute (s2) and pptate. (p2) and this process is repeated until sm is produced strongly enriched in the least soluble component (sic) together with pm. Esp. for fractionating the condensed tannins (a catechol tannin T1 and 2 proanthocyanidol tannins T2 and T3) obtd. by extracting fresh cypress cones. T2, and much less so T3, have vasoconstrictor activity and both reduce capillary permeability at doses lower than rutin; R2 has highly selective action against the pain associated with acute haemorrhoidal crises (prophylactic or curative treatment of circulatory disorders of the legs) and T3 is useful for treating disordered vision caused by chronic circulatory disturbances. T2 and T3 have i.p. LD5o >1.5 g/kg.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7422898A FR2276830A1 (en) | 1974-07-01 | 1974-07-01 | Fractionating non-voltatile solids by partial precipitation - esp for recovering condensed tannins having circulatory activity from cypress berries |
| DE19752559722 DE2559722A1 (en) | 1974-07-01 | 1975-07-01 | DRUG |
| DE19752529294 DE2529294A1 (en) | 1974-07-01 | 1975-07-01 | NEW PROCESS FOR FRACTIONATION OF MIXTURES OF VOLATILE SOLIDS AND APPLICATION OF THE PROCESS TO THE FRACTIONATION OF CONDENSED TANNINS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7422898A FR2276830A1 (en) | 1974-07-01 | 1974-07-01 | Fractionating non-voltatile solids by partial precipitation - esp for recovering condensed tannins having circulatory activity from cypress berries |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2276830A1 true FR2276830A1 (en) | 1976-01-30 |
| FR2276830B1 FR2276830B1 (en) | 1978-07-21 |
Family
ID=9140750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7422898A Granted FR2276830A1 (en) | 1974-07-01 | 1974-07-01 | Fractionating non-voltatile solids by partial precipitation - esp for recovering condensed tannins having circulatory activity from cypress berries |
Country Status (2)
| Country | Link |
|---|---|
| DE (2) | DE2559722A1 (en) |
| FR (1) | FR2276830A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0269545A1 (en) * | 1986-10-17 | 1988-06-01 | Bar Ilan University | Food supplements containing a Vitamine E antioxidant activity simulator |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994023732A1 (en) * | 1993-04-08 | 1994-10-27 | Kambourakis Medicinal Solutions Pty. Limited | Therapeutic preparations containing cypress tree extracts and methods of using same |
-
1974
- 1974-07-01 FR FR7422898A patent/FR2276830A1/en active Granted
-
1975
- 1975-07-01 DE DE19752559722 patent/DE2559722A1/en not_active Withdrawn
- 1975-07-01 DE DE19752529294 patent/DE2529294A1/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0269545A1 (en) * | 1986-10-17 | 1988-06-01 | Bar Ilan University | Food supplements containing a Vitamine E antioxidant activity simulator |
| US4976960A (en) * | 1986-10-17 | 1990-12-11 | Bar Ilan University | Food supplements |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2529294A1 (en) | 1976-01-15 |
| FR2276830B1 (en) | 1978-07-21 |
| DE2559722A1 (en) | 1977-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| ST | Notification of lapse |