FR2320302A1 - Procede de preparation de 11-aminovincamine dextrogyre, de 11-aminovincamine levogyre, de 11-aminovincamine racemique et derives indoliques nouveaux - Google Patents
Procede de preparation de 11-aminovincamine dextrogyre, de 11-aminovincamine levogyre, de 11-aminovincamine racemique et derives indoliques nouveauxInfo
- Publication number
- FR2320302A1 FR2320302A1 FR7524390A FR7524390A FR2320302A1 FR 2320302 A1 FR2320302 A1 FR 2320302A1 FR 7524390 A FR7524390 A FR 7524390A FR 7524390 A FR7524390 A FR 7524390A FR 2320302 A1 FR2320302 A1 FR 2320302A1
- Authority
- FR
- France
- Prior art keywords
- vincamine
- redn
- nitration
- prepd
- vasoregulator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 title abstract 5
- 229960002726 vincamine Drugs 0.000 title abstract 4
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 title abstract 3
- 238000006396 nitration reaction Methods 0.000 title abstract 3
- 230000002490 cerebral effect Effects 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 2
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 2
- 229960000583 acetic acid Drugs 0.000 abstract 2
- 239000012362 glacial acetic acid Substances 0.000 abstract 2
- 229910017604 nitric acid Inorganic materials 0.000 abstract 2
- 239000007868 Raney catalyst Substances 0.000 abstract 1
- 229910000564 Raney nickel Inorganic materials 0.000 abstract 1
- 229910021626 Tin(II) chloride Inorganic materials 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 235000011150 stannous chloride Nutrition 0.000 abstract 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7524390A FR2320302A1 (fr) | 1975-08-05 | 1975-08-05 | Procede de preparation de 11-aminovincamine dextrogyre, de 11-aminovincamine levogyre, de 11-aminovincamine racemique et derives indoliques nouveaux |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7524390A FR2320302A1 (fr) | 1975-08-05 | 1975-08-05 | Procede de preparation de 11-aminovincamine dextrogyre, de 11-aminovincamine levogyre, de 11-aminovincamine racemique et derives indoliques nouveaux |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2320302A1 true FR2320302A1 (fr) | 1977-03-04 |
| FR2320302B3 FR2320302B3 (fr) | 1978-03-24 |
Family
ID=9158774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7524390A Granted FR2320302A1 (fr) | 1975-08-05 | 1975-08-05 | Procede de preparation de 11-aminovincamine dextrogyre, de 11-aminovincamine levogyre, de 11-aminovincamine racemique et derives indoliques nouveaux |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2320302A1 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2339618A1 (fr) * | 1976-01-30 | 1977-08-26 | Omnium Chimique Sa | Procede de preparation de (-)11-aminovincamone, de 11-aminoeburamonine, de 11-aminovincamone racemique et derives indoliques nouveaux |
| EP0170926A1 (fr) * | 1984-07-11 | 1986-02-12 | Richter Gedeon Vegyeszeti Gyar R.T. | Dérivés de l'acide éburnanecarboxylique ayant, sur la position 9 ou sur la position 11, un groupe amino qui est éventuellement substitué, procédé pour leur préparation et médicaments contenant ces dérivés |
| EP0173824A1 (fr) * | 1984-07-11 | 1986-03-12 | Richter Gedeon Vegyészeti Gyár R.T. | Dérivés de l'acide apovincaminique, racémiques ou optiquement actifs, substitués sur la position 9 et/ou sur la position 11 et procédé pour leur préparation |
| EP0307167A3 (fr) * | 1987-09-07 | 1990-01-24 | Taisho Pharmaceutical Co. Ltd | Dérivés de l'acide vincaminique |
-
1975
- 1975-08-05 FR FR7524390A patent/FR2320302A1/fr active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2339618A1 (fr) * | 1976-01-30 | 1977-08-26 | Omnium Chimique Sa | Procede de preparation de (-)11-aminovincamone, de 11-aminoeburamonine, de 11-aminovincamone racemique et derives indoliques nouveaux |
| EP0170926A1 (fr) * | 1984-07-11 | 1986-02-12 | Richter Gedeon Vegyeszeti Gyar R.T. | Dérivés de l'acide éburnanecarboxylique ayant, sur la position 9 ou sur la position 11, un groupe amino qui est éventuellement substitué, procédé pour leur préparation et médicaments contenant ces dérivés |
| EP0173824A1 (fr) * | 1984-07-11 | 1986-03-12 | Richter Gedeon Vegyészeti Gyár R.T. | Dérivés de l'acide apovincaminique, racémiques ou optiquement actifs, substitués sur la position 9 et/ou sur la position 11 et procédé pour leur préparation |
| EP0307167A3 (fr) * | 1987-09-07 | 1990-01-24 | Taisho Pharmaceutical Co. Ltd | Dérivés de l'acide vincaminique |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2320302B3 (fr) | 1978-03-24 |
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