FR2348932A1 - Corticosteroides et medicaments qui en contiennent - Google Patents

Corticosteroides et medicaments qui en contiennent

Info

Publication number: FR2348932A1
Authority: FR; France
Prior art keywords: difluoro; cortolone; prepd; corticoid; esterifying
Prior art date: 1976-04-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

FR7712003A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Schering AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-04-21

Filing date

1977-04-21

Publication date

1977-11-18

1977-04-21 Application filed by Schering AG filed Critical Schering AG

1977-11-18 Publication of FR2348932A1 publication Critical patent/FR2348932A1/fr

Status Withdrawn legal-status Critical Current

Links

LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title abstract 2
230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 title 1
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 title 1
239000003470 adrenal cortex hormone Substances 0.000 title 1
RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 title 1
229940070710 valerate Drugs 0.000 title 1
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 title 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
OGPWIDANBSLJPC-RFPWEZLHSA-N diflucortolone Chemical class C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@H](C(=O)CO)[C@@]2(C)C[C@@H]1O OGPWIDANBSLJPC-RFPWEZLHSA-N 0.000 abstract 3
229960004091 diflucortolone Drugs 0.000 abstract 2
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
238000010992 reflux Methods 0.000 abstract 2
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
YHASWHZGWUONAO-UHFFFAOYSA-N butanoyl butanoate Chemical compound CCCC(=O)OC(=O)CCC YHASWHZGWUONAO-UHFFFAOYSA-N 0.000 abstract 1
FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 abstract 1
DUCKXCGALKOSJF-UHFFFAOYSA-N pentanoyl pentanoate Chemical compound CCCCC(=O)OC(=O)CCCC DUCKXCGALKOSJF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
- C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
- C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)

FR7712003A 1976-04-21 1977-04-21 Corticosteroides et medicaments qui en contiennent Withdrawn FR2348932A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19762617655 DE2617655C2 (de)	1976-04-21	1976-04-21	Kortikoide, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate

Publications (1)

Publication Number	Publication Date
FR2348932A1 true FR2348932A1 (fr)	1977-11-18

Family

ID=5975969

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR7712003A Withdrawn FR2348932A1 (fr)	1976-04-21	1977-04-21	Corticosteroides et medicaments qui en contiennent

Country Status (5)

Country	Link
JP (1)	JPS52128364A (fr)
DE (1)	DE2617655C2 (fr)
ES (1)	ES457968A1 (fr)
FR (1)	FR2348932A1 (fr)
NL (1)	NL7704218A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2127739C1 (ru) *	1993-02-05	1999-03-20	Руссель Юклаф	СПОСОБ ПОЛУЧЕНИЯ 6α, 9α-ДИФТОРИРОВАННЫХ СТЕРОИДОВ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2829953A1 (de) *	1978-07-03	1980-01-24	Schering Ag	Pharmazeutische zubereitung zur behandlung der kolitis ulcerosa und kolitis granulomatosa
DE2920726A1 (de) *	1979-05-18	1980-11-27	Schering Ag	Neue kortikoide, ihre herstellung und verwendung
PT78973A (en) *	1984-07-25	1984-08-01	Joao Emerico Villax	New preparation process of the 9alpha-fluoro 17,21-acylates or hidroxilades in 17 and 21 chloro-corticosteroid
DE4433374A1 (de) *	1994-09-20	1996-03-21	Hoechst Ag	17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
IL125004A0 (en) *	1995-12-20	1999-01-26	Schering Corp	Process for the preparation of 9,11 beta-epoxide steroids
CN103130860B (zh) *	2011-11-30	2016-05-18	天津金耀集团有限公司	一种双氟可龙戊酸酯新晶型及其制备的局部外用制剂

1976
- 1976-04-21 DE DE19762617655 patent/DE2617655C2/de not_active Expired
- 1976-08-10 JP JP9533876A patent/JPS52128364A/ja active Pending
1977
- 1977-04-18 NL NL7704218A patent/NL7704218A/xx not_active Application Discontinuation
- 1977-04-20 ES ES457968A patent/ES457968A1/es not_active Expired
- 1977-04-21 FR FR7712003A patent/FR2348932A1/fr not_active Withdrawn

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2127739C1 (ru) *	1993-02-05	1999-03-20	Руссель Юклаф	СПОСОБ ПОЛУЧЕНИЯ 6α, 9α-ДИФТОРИРОВАННЫХ СТЕРОИДОВ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ

Also Published As

Publication number	Publication date
DE2617655C2 (de)	1984-11-08
JPS52128364A (en)	1977-10-27
NL7704218A (nl)	1977-10-25
DE2617655A1 (de)	1977-11-03
ES457968A1 (es)	1978-02-01

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Legal Events

Date	Code	Title	Description
1980-02-22	ST	Notification of lapse