FR2356420A2 - Nouvelles amino-3 3h-isobenzofurannones n-substituees et leur application therapeutique - Google Patents

Nouvelles amino-3 3h-isobenzofurannones n-substituees et leur application therapeutique

Info

Publication number: FR2356420A2
Authority: FR; France
Prior art keywords: substd; cr1r2; alkyl; isobenzofuanones; antiinflammatories
Prior art date: 1976-07-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

FR7620048A

Other languages

English (en)

French (fr)

Other versions

FR2356420B2 (2

Inventor

Fauran

Feniou

Prat

Thibault

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cortial SA

Original Assignee

Cortial SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-07-01

Filing date

1976-07-01

Publication date

1978-01-27

1976-07-01 Application filed by Cortial SA filed Critical Cortial SA

1976-07-01 Priority to FR7620048A priority Critical patent/FR2356420A2/fr

1976-07-08 Priority to DE2630764A priority patent/DE2630764C2/de

1976-07-08 Priority to PT65342A priority patent/PT65342B/pt

1976-07-08 Priority to US05/703,602 priority patent/US4122202A/en

1976-07-09 Priority to NL7607623A priority patent/NL7607623A/xx

1976-08-13 Priority to ZA770198A priority patent/ZA77198B/xx

1978-01-27 Publication of FR2356420A2 publication Critical patent/FR2356420A2/fr

1982-06-04 Application granted granted Critical

1982-06-04 Publication of FR2356420B2 publication Critical patent/FR2356420B2/fr

Status Granted legal-status Critical Current

Links

230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 title 2
DYNFCHNNOHNJFG-UHFFFAOYSA-N 2-formylbenzoic acid Chemical compound OC(=O)C1=CC=CC=C1C=O DYNFCHNNOHNJFG-UHFFFAOYSA-N 0.000 title 1
229940035676 analgesics Drugs 0.000 title 1
239000000730 antalgic agent Substances 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
229940121363 anti-inflammatory agent Drugs 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000001424 substituent group Chemical group 0.000 abstract 2
WNZQDUSMALZDQF-UHFFFAOYSA-N 2-benzofuran-1(3H)-one Chemical class C1=CC=C2C(=O)OCC2=C1 WNZQDUSMALZDQF-UHFFFAOYSA-N 0.000 abstract 1
125000002015 acyclic group Chemical group 0.000 abstract 1
125000002723 alicyclic group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003501 anti-edematous effect Effects 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
231100000053 low toxicity Toxicity 0.000 abstract 1
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
-1 pref. OH Chemical group 0.000 abstract 1
125000006413 ring segment Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001562 ulcerogenic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FR7620048A 1975-07-09 1976-07-01 Nouvelles amino-3 3h-isobenzofurannones n-substituees et leur application therapeutique Granted FR2356420A2 (fr)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
FR7620048A FR2356420A2 (fr)	1976-07-01	1976-07-01	Nouvelles amino-3 3h-isobenzofurannones n-substituees et leur application therapeutique
DE2630764A DE2630764C2 (de)	1975-07-09	1976-07-08	N-Substituierte 3-Amino-3H-isobenzofuranone und diese Verbindungen enthaltende Arzneimittel
PT65342A PT65342B (fr)	1975-07-09	1976-07-08	Proces de preparation de nouvelles amino-3 3h-isobenzo-furanones n-substituees
US05/703,602 US4122202A (en)	1975-07-09	1976-07-08	Amino-3H-isobenzofuranones N-substitutes and their therapeutic application
NL7607623A NL7607623A (nl)	1975-07-09	1976-07-09	Werkwijze voor de bereiding van verbindingen en preparaten met pijnstillende en anti-oedeem-wer- king.
ZA770198A ZA77198B (en)	1976-07-01	1976-08-13	New n-substituted 3-amino 3h-1-isobenzofuranones and their use as medicines

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR7620048A FR2356420A2 (fr)	1976-07-01	1976-07-01	Nouvelles amino-3 3h-isobenzofurannones n-substituees et leur application therapeutique

Publications (2)

Publication Number	Publication Date
FR2356420A2 true FR2356420A2 (fr)	1978-01-27
FR2356420B2 FR2356420B2 (2)	1982-06-04

Family

ID=9175098

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR7620048A Granted FR2356420A2 (fr)	1975-07-09	1976-07-01	Nouvelles amino-3 3h-isobenzofurannones n-substituees et leur application therapeutique

Country Status (2)

Country	Link
FR (1)	FR2356420A2 (2)
ZA (1)	ZA77198B (2)

1976
- 1976-07-01 FR FR7620048A patent/FR2356420A2/fr active Granted
- 1976-08-13 ZA ZA770198A patent/ZA77198B/xx unknown

Also Published As

Publication number	Publication date
ZA77198B (en)	1977-11-30
FR2356420B2 (2)	1982-06-04

Publication	Publication Date	Title
GB1433774A (en)	1976-04-28	Heterocyclic compounds apparatus for conveying articles
DK245888D0 (da)	1988-05-05	4-aminoquinolinderivater
DK543787A (da)	1988-04-21	Naphthyridin-, quinolin- og benzoxazincarboxylsyreforbindelser med antibakteriel aktivitet
AR247732A1 (es)	1995-03-31	Procedimiento para obtener amidas de acido piridin-2, 4- y -2, 5-dicarboxilico
GB1277153A (en)	1972-06-07	N-phenylsulfamoyl and n-phenylsulfonyl-amino salicylic acids and their derivatives
GB1083193A (en)	1967-09-13	Guanidine derivatives and process for their manufacture
ES450881A1 (es)	1977-12-16	Un procedimiento de preparacion de acidos heteroarilbenzoxe-pin-aceticos y sus derivados.
ES472588A1 (es)	1980-04-16	Un procedimiento para la preparacion de un nuevo derivado deacido cicloalquilidenmetilfenilacetico
GB1446484A (en)	1976-08-18	Penicillins their preparation and use
ES453309A1 (es)	1977-11-16	Un procedimiento de preparacion de derivados de acidos dife-noxi-2-alcanocarboxilicos.
ES461399A1 (es)	1978-05-16	Procedimiento para preparar esteres de epinina con acidos carboxilicos de cadena ramificada.
ES445994A1 (es)	1977-10-01	Procedimiento para la obtencion de derivados de acido para- aminobenzoico.
GB1459065A (en)	1976-12-22	Therapeutic thiophene derivatives
ES443616A1 (es)	1977-05-01	Procedimiento para la fabricacion de nuevos derivados 1,3- disustituidos del propanol-(2) y sus esteres de acido nico- tinico.
ES8701752A1 (es)	1986-12-01	Un procedimiento para preparar derivados de bencimidazol
ES463240A1 (es)	1978-09-01	Procedimiento para la preparacion de acidos pirazol-1-il-fe-nilaceticos.
FR2316938A1 (fr)	1977-02-04	Nouvelles amino-3 3h-isobenzofurannones-1 n-substituees et leur application therapeutique
FR2356420A2 (fr)	1978-01-27	Nouvelles amino-3 3h-isobenzofurannones n-substituees et leur application therapeutique
FR2356421A2 (fr)	1978-01-27	Nouvelles amino-3 3h-isobenzofurannones n-substituees et leur application therapeutique
GB1363195A (en)	1974-08-14	Propenylamine derivatives and process for the production thereof
IE781078L (en)	1978-12-01	Amino acids.
GB1394504A (en)	1975-05-14	1,2-bis-4-phenyl-1-piperazinyl-ethane derivatives
GB1425578A (en)	1976-02-18	Piperidine derivatives
GB1349138A (en)	1974-03-27	Quinazoline derivative
GB1460936A (en)	1977-01-06	Benzodiazepines