FR2365570A1 - Monohydrate cristallin de cefadroxile et son procede de preparation - Google Patents

Monohydrate cristallin de cefadroxile et son procede de preparation

Info

Publication number
FR2365570A1
FR2365570A1 FR7738820A FR7738820A FR2365570A1 FR 2365570 A1 FR2365570 A1 FR 2365570A1 FR 7738820 A FR7738820 A FR 7738820A FR 7738820 A FR7738820 A FR 7738820A FR 2365570 A1 FR2365570 A1 FR 2365570A1
Authority
FR
France
Prior art keywords
preparation process
cefadroxil
crystalline monohydrate
gram
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7738820A
Other languages
English (en)
Other versions
FR2365570B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10087928&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2365570(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2365570A1 publication Critical patent/FR2365570A1/fr
Application granted granted Critical
Publication of FR2365570B1 publication Critical patent/FR2365570B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne le monohydrate cristallin de céfadroxile et son procédé de préparation. Le nouveau composé de l'invention est un antibiotique oral du type de la céphalosporine, doué d'activité antibactérienne contre des microorganismes Gram-positifs et Gram-négatifs.
FR7738820A 1976-04-27 1977-12-22 Monohydrate cristallin de cefadroxile et son procede de preparation Granted FR2365570A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB17028/76A GB1532682A (en) 1976-04-27 1976-04-27 Process for the preparation of cephadroxil

Publications (2)

Publication Number Publication Date
FR2365570A1 true FR2365570A1 (fr) 1978-04-21
FR2365570B1 FR2365570B1 (fr) 1980-06-06

Family

ID=10087928

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7712622A Granted FR2349589A1 (fr) 1976-04-27 1977-04-26 Procede de preparation d'une cephalosporine et produit obtenu
FR7738820A Granted FR2365570A1 (fr) 1976-04-27 1977-12-22 Monohydrate cristallin de cefadroxile et son procede de preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7712622A Granted FR2349589A1 (fr) 1976-04-27 1977-04-26 Procede de preparation d'une cephalosporine et produit obtenu

Country Status (26)

Country Link
US (3) US4234721A (fr)
JP (2) JPS6022717B2 (fr)
AT (1) AT350183B (fr)
AU (1) AU510338B2 (fr)
BE (1) BE853974A (fr)
CA (1) CA1115268A (fr)
CH (1) CH632270A5 (fr)
CY (1) CY1066A (fr)
DE (1) DE2718741C2 (fr)
DK (1) DK157026C (fr)
ES (1) ES458241A1 (fr)
FI (1) FI67704C (fr)
FR (2) FR2349589A1 (fr)
GB (1) GB1532682A (fr)
GR (1) GR72788B (fr)
HK (1) HK39780A (fr)
IE (1) IE44872B1 (fr)
IT (1) IT8049917A0 (fr)
KE (1) KE3064A (fr)
LU (1) LU77202A1 (fr)
MY (1) MY8100135A (fr)
NL (1) NL7704618A (fr)
PH (2) PH16581A (fr)
SE (1) SE437521B (fr)
YU (2) YU39801B (fr)
ZA (1) ZA772485B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0302145A3 (en) * 1987-08-03 1989-08-23 Rifar S.R.L. Method for preparing crystalline cefadroxil monohydrate
EP0295333A3 (en) * 1987-06-17 1989-10-18 Rifar S.R.L. Substantially anhydrous crystalline cefadroxil and method for producing it
EP0287751A3 (en) * 1987-04-24 1990-05-02 Rifar Srl Novel crystalline cefadroxil and method for producing it
EP0528941A4 (en) * 1990-05-10 1994-07-06 Biocraft Laboratories Inc Process for preparing cephalexin monohydrate

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1126544B (it) 1979-12-07 1986-05-21 Dobfar Spa Procedimento per la preparazione di derivati dell'acido 7-amino-desacetossi cefalosporanico
KR820001564B1 (ko) * 1981-05-09 1982-09-02 동신제약 주식회사 새로운 실릴화제를 이용한 세팔로스포린 유도체의 제조방법
FR2555989B1 (fr) * 1983-12-06 1987-02-20 Bristol Myers Sa Monohydrate de chlorocephadroxyle
JPS60169486A (ja) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
US4962195A (en) * 1987-04-24 1990-10-09 Rifar S.R.L. Solvate of cefadroxyl
US5023331A (en) * 1987-04-24 1991-06-11 Rifar S.R.L. Cefadroxil solvates
IT1233863B (it) * 1988-02-24 1992-04-21 Opos Biochimica Srl Procedimento per la preparazione dell'acido 7-(d(-)-alfa-amino-alfa- (p-idrossifenil)acetamido)-3-metil-3-cefem-4-carbossilico monoidrato
US5034522A (en) * 1988-08-02 1991-07-23 Biocraft Laboratories, Inc. Method for the production of 3-methyl cephem derivatives
ES2023560A6 (es) * 1989-07-10 1992-01-16 Gema Sa Procedimiento para la produccion de hidrato de cefradina y solvato de cefradina y dimetilformamida.
US6248881B1 (en) 1991-03-08 2001-06-19 Biochemie Gmbh Intermediates and process for the production of 3-vinyl cephalosporins
ES2157199T3 (es) 1991-03-08 2001-08-16 Biochemie Gmbh Nuevo procedimiento para la produccion de cefalosporinas y nuevos compuestos intermedios para este procedimiento.
AT396106B (de) * 1991-03-08 1993-06-25 Biochemie Gmbh Neues verfahren zur herstellung von 3-vinylcephalosporinverbindungen
US5721359A (en) * 1993-03-12 1998-02-24 Pharmacia & Upjohn Company Crystalline ceftiofur free acid
US5604222A (en) * 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
SK282424B6 (sk) 1994-04-15 2002-01-07 Pharmacia + Upjohn Company "S" a "T" kryštalické formy 1-[5-metánsulfónamidoindolyl-2- karbonyl]-4-[3-(1-metyl-etylamino)-2-pyridinyl] piperazínu
US5578721A (en) * 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
US5574154A (en) * 1994-09-29 1996-11-12 Alnejma Bulk Pharmaceutical Co. A.B.P.C. Process for the preparation of cephalosporanic compounds
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
IT1289955B1 (it) * 1997-02-21 1998-10-19 Solchem Italiana Spa Acyclovir sale sodico biidrato e sua preparazione
US6080427A (en) * 1997-04-17 2000-06-27 Bristol-Myers Squibb Company Cefadroxil monohydrate tablet formulation
WO2001004126A1 (fr) * 1999-07-14 2001-01-18 Ranbaxy Laboratories Limited Procede de preparation de semi-hydrate cefadroxil cristallin a partir d'un produit de solvatation cefadroxil dimethyl formamide
IN190389B (fr) 1999-07-14 2003-07-26 Ranbaxy Lab Ltd
US20060173064A1 (en) * 2001-08-24 2006-08-03 Lippa Arnold S (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders
US6569887B2 (en) * 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
US20040077849A1 (en) * 2002-10-16 2004-04-22 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefadroxil
PL376604A1 (pl) * 2002-11-08 2006-01-09 Dov Pharmaceuticals, Inc. Polimorfy chlorowodorku bicifadyny
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
US7230097B2 (en) 2003-03-10 2007-06-12 Lupin Ltd. Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid
US20070072945A1 (en) * 2004-03-31 2007-03-29 Pohoreski Anton Sulphur-containing oils for controlling plant pathogens and stimulating nutrient uptake
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
US20060100263A1 (en) * 2004-11-05 2006-05-11 Anthony Basile Antipyretic compositions and methods
NZ592836A (en) 2005-07-27 2013-01-25 Dov Pharmaceutical Inc Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
CN101448842A (zh) * 2006-05-19 2009-06-03 帝斯曼知识产权资产管理有限公司 一种用于结晶头孢羟氨苄的方法
US20080269348A1 (en) * 2006-11-07 2008-10-30 Phil Skolnick Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use
US8138377B2 (en) * 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
WO2008092231A1 (fr) 2007-02-01 2008-08-07 Resverlogix Corp. Composés destinés à la prévention et au traitement de maladies cardiovasculaires
US20090069374A1 (en) * 2007-06-06 2009-03-12 Phil Skolnick Novel 1-Heteroaryl-3-Azabicyclo[3.1.0]Hexanes, Methods For Their Preparation And Their Use As Medicaments
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
NZ755378A (en) 2009-03-18 2022-07-29 Resverlogix Corp Novel quinazolinones and related compounds for use as anti-inflammatory agents
CN102408438B (zh) * 2010-09-26 2015-01-07 石药集团中奇制药技术（石家庄）有限公司 一种头孢丙烯一水合物的制备方法
CN102134250B (zh) * 2011-01-19 2013-03-13 天津大学 一种头孢羟氨苄单水合物的结晶方法及结晶
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USB516047I5 (fr) * 1972-09-15 1976-02-10

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US29164A (en) * 1860-07-17 Improvement in fish-oils
US3489751A (en) 1967-09-05 1970-01-13 Bristol Myers Co 7-amino-cephalosporanic and decephalosporanic acid derivatives
USRE29164E (en) 1967-09-05 1977-03-29 Bristol-Myers Company 7-Amino-cephalosporanic and decephalosporanic acid derivatives
US3655656A (en) * 1970-06-04 1972-04-11 Lilly Co Eli Crystalline cephalexin monohydrate
US3694437A (en) * 1970-08-19 1972-09-26 Lilly Co Eli Process for preparing cephalosporin compounds
US3781282A (en) * 1971-01-20 1973-12-25 W Garbrecht Cephalosporin process and product
DE2163514A1 (de) * 1971-12-21 1973-07-05 Toyama Chemical Co Ltd Verfahren zur herstellung von cephalosporinen
FR2166316A1 (en) * 1972-01-07 1973-08-17 Toyama Chemical Co Ltd 7-acylcephalosporins - prepd via a silylated inter
GB1472746A (en) * 1973-07-05 1977-05-04 Glaxo Lab Ltd Cephalosporin compounds
US4091215A (en) * 1974-06-05 1978-05-23 Bristol-Myers Company 7-D-α-Amino-.alpha.-(p-acetoxyphenyl)acetamido-3-methyl-3-cephem-4-carboxylic acid
GB1476981A (en) 1974-06-05 1977-06-16 Bristol Myers Co Substituted penicillanic acids
AU2550077A (en) * 1976-06-14 1978-11-30 Merck Patent Gmbh Penicillins and cephalosporins
US4160863A (en) * 1977-04-07 1979-07-10 Bristol-Myers Company Process for the preparation of the crystalline monohydrate of 7-[D-α-aα-(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acid
NL162387C (nl) * 1977-09-06 1980-05-16 Gist Brocades Nv Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur.
IT1126544B (it) * 1979-12-07 1986-05-21 Dobfar Spa Procedimento per la preparazione di derivati dell'acido 7-amino-desacetossi cefalosporanico

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USB516047I5 (fr) * 1972-09-15 1976-02-10

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0287751A3 (en) * 1987-04-24 1990-05-02 Rifar Srl Novel crystalline cefadroxil and method for producing it
EP0295333A3 (en) * 1987-06-17 1989-10-18 Rifar S.R.L. Substantially anhydrous crystalline cefadroxil and method for producing it
US5329001A (en) * 1987-06-17 1994-07-12 Rifar S.R.L. Substantially anhydrous crystalline cefadroxil and method for producing it
EP0302145A3 (en) * 1987-08-03 1989-08-23 Rifar S.R.L. Method for preparing crystalline cefadroxil monohydrate
EP0528941A4 (en) * 1990-05-10 1994-07-06 Biocraft Laboratories Inc Process for preparing cephalexin monohydrate

Also Published As

Publication number Publication date
CY1066A (en) 1980-10-24
DE2718741C2 (de) 1985-03-21
NL7704618A (nl) 1977-10-31
IE44872B1 (en) 1982-04-21
GR72788B (fr) 1983-12-05
CH632270A5 (de) 1982-09-30
IT8049917A0 (it) 1980-10-16
BE853974A (fr) 1977-10-26
HK39780A (en) 1980-08-08
SE7704739L (sv) 1977-12-01
PH16581A (en) 1983-11-22
JPH0246009B2 (fr) 1990-10-12
DK157026B (da) 1989-10-30
FI67704C (fi) 1985-05-10
US4504657A (en) 1985-03-12
YU108677A (en) 1982-10-31
GB1532682A (en) 1978-11-22
USRE31730E (en) 1984-11-13
FR2365570B1 (fr) 1980-06-06
ATA296277A (de) 1978-10-15
AU510338B2 (en) 1980-06-19
AT350183B (de) 1979-05-10
SE437521B (sv) 1985-03-04
FR2349589B1 (fr) 1981-11-20
YU137982A (en) 1983-04-30
DK183277A (da) 1977-10-28
YU43081B (en) 1989-02-28
PH17254A (en) 1984-07-03
AU2460777A (en) 1978-11-02
FI771339A7 (fr) 1977-10-28
ES458241A1 (es) 1978-11-01
US4234721A (en) 1980-11-18
IE44872L (en) 1977-10-27
FR2349589A1 (fr) 1977-11-25
ZA772485B (en) 1978-03-29
FI67704B (fi) 1985-01-31
LU77202A1 (fr) 1977-11-22
CA1115268A (fr) 1981-12-29
MY8100135A (en) 1981-12-31
JPS6022717B2 (ja) 1985-06-03
DE2718741A1 (de) 1977-11-17
DK157026C (da) 1990-04-02
KE3064A (en) 1980-07-25
JPS60185718A (ja) 1985-09-21
YU39801B (en) 1985-04-30
JPS52142091A (en) 1977-11-26

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