FR2372635A1 - Nouvelle composition pharmaceutique contenant une huile auto-emulsionnante - Google Patents
Nouvelle composition pharmaceutique contenant une huile auto-emulsionnanteInfo
- Publication number
- FR2372635A1 FR2372635A1 FR7736418A FR7736418A FR2372635A1 FR 2372635 A1 FR2372635 A1 FR 2372635A1 FR 7736418 A FR7736418 A FR 7736418A FR 7736418 A FR7736418 A FR 7736418A FR 2372635 A1 FR2372635 A1 FR 2372635A1
- Authority
- FR
- France
- Prior art keywords
- capsules
- silicone
- self
- admin
- contg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002775 capsule Substances 0.000 title abstract 2
- 229920001296 polysiloxane Polymers 0.000 title abstract 2
- 230000002496 gastric effect Effects 0.000 title 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 108010006654 Bleomycin Proteins 0.000 abstract 1
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 abstract 1
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001857 anti-mycotic effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000002543 antimycotic Substances 0.000 abstract 1
- 229960001561 bleomycin Drugs 0.000 abstract 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 abstract 1
- 229960004782 chlordiazepoxide Drugs 0.000 abstract 1
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 abstract 1
- 229960003957 dexamethasone Drugs 0.000 abstract 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 abstract 1
- 229960003529 diazepam Drugs 0.000 abstract 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 229960003883 furosemide Drugs 0.000 abstract 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 229960002867 griseofulvin Drugs 0.000 abstract 1
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 abstract 1
- 229960000905 indomethacin Drugs 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 150000002960 penicillins Chemical class 0.000 abstract 1
- 229960005205 prednisolone Drugs 0.000 abstract 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne une nouvelle composition pharmaceutiquement active. La composition de l'invention contient une quantité posologique unitaire de composants pharmaceutiques en suspension ou en solution dans une huile auto-émulsionnante qui comprend un composant huile et un composant tensio-actif. Sous une forme de réalisation appréciée, la composition est renfermée dans une capsule de gélatine élastique molle, d'une seule pièce. L'ingrédient actif est par exemple un médicament stéroïde, un antifongique, un tranquillisant, un sédatif, un diurétique, un agent anti-in ammatoire, un agent analgésique, un antibiotique ou l'insuline.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5057776 | 1976-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2372635A1 true FR2372635A1 (fr) | 1978-06-30 |
Family
ID=10456450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7736418A Withdrawn FR2372635A1 (fr) | 1976-12-03 | 1977-12-02 | Nouvelle composition pharmaceutique contenant une huile auto-emulsionnante |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5372814A (fr) |
| AU (1) | AU3111677A (fr) |
| DE (1) | DE2753526A1 (fr) |
| FR (1) | FR2372635A1 (fr) |
| IT (1) | IT1090703B (fr) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2491333A1 (fr) * | 1980-10-06 | 1982-04-09 | Glaxo Group Ltd | Compositions pharmaceutiques administrables par voie topique et contenant des steroides anti-inflammatoires |
| FR2500302A1 (fr) * | 1981-02-25 | 1982-08-27 | Negma Laboratoires | Nouvelles compositions pharmaceutiques d'indometacine |
| FR2549371A1 (fr) * | 1983-07-20 | 1985-01-25 | Sanofi Sa | Nouvelle composition pharmaceutique contenant de l'acide valproique ou un de ses sels |
| EP0130514A3 (fr) * | 1983-07-05 | 1986-08-13 | Troponwerke GmbH & Co. KG | Compositions antiphlogistiques à effet dépôt |
| EP0343575A1 (fr) * | 1988-05-24 | 1989-11-29 | Günter Stephan | Capsule de gélatine molle |
| EP0517412A1 (fr) * | 1991-06-03 | 1992-12-09 | MERCK SHARP & DOHME LTD. | Formulations pharmaceutiques d'une benzodiazepine |
| WO1994007472A1 (fr) * | 1992-10-02 | 1994-04-14 | Pfizer Inc. | Compositions pharmaceutiques contenant des tensioactifs non ioniques |
| WO1995012384A1 (fr) * | 1993-11-02 | 1995-05-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Formulation auto-emulsionnable formant une huile dans eau |
| WO1995024893A1 (fr) * | 1994-03-16 | 1995-09-21 | R.P. Scherer Limited | Systemes d'administration s'appliquant a des medicaments hydrophobes |
| WO1996019195A1 (fr) * | 1994-12-22 | 1996-06-27 | Laboratoire Innothera | Forme galenique unitaire destinee a la voie vaginale utilisable comme contraceptif local et/ou pour combattre les maladies sexuellement transmissibles et/ou les vih |
| WO1999056727A3 (fr) * | 1998-05-07 | 2000-03-02 | Elan Corp Plc | Systemes d'apport de medicament de preconcentre de microemulsion et d'emulsion depourvues de solvant/cosolvant |
| EP1420767A4 (fr) * | 2001-08-27 | 2004-11-24 | Won Jin Biopharma Co Ltd | Compositions contenant de l'itraconazole et leurs procedes de preparation |
| WO2020157675A1 (fr) * | 2019-01-31 | 2020-08-06 | Gdański Uniwersytet Medyczny Z Siedzibą W Gdańsku | Composition pharmaceutique auto-émulsifiante sous forme liquide, contenant comme substance active une substance médicamenteuse instable dans un environnement aqueux |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8904182D0 (en) * | 1989-02-23 | 1989-04-05 | Glaxo Canada | Pharmaceutical compositions |
| DE4322826A1 (de) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmazeutisches Präparat |
| JP2006521366A (ja) * | 2003-03-28 | 2006-09-21 | シグモイド・バイオテクノロジーズ・リミテッド | シームレスマイクロカプセルを含む固形経口剤形 |
| JP5300477B2 (ja) * | 2006-08-01 | 2013-09-25 | 大塚製薬株式会社 | 薬理活性物質の吸収性が改善された医薬組成物 |
| EP2061440A2 (fr) | 2007-04-04 | 2009-05-27 | Sigmoid Pharma Limited | Composition pharmaceutique à base de tacrolimus |
| ES2963291T3 (es) | 2007-04-26 | 2024-03-26 | Sublimity Therapeutics Ltd | Fabricación de múltiples minicápsulas |
| ES2530049T3 (es) | 2009-05-18 | 2015-02-26 | Sigmoid Pharma Limited | Composición que comprende gotas de aceite |
| BR112012002963A2 (pt) | 2009-08-12 | 2017-10-24 | Sigmoid Pharma Ltd | composições imunomoduladoras compreendendo uma matriz de polímero e uma fase oleosa |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| US9320690B2 (en) * | 2010-12-20 | 2016-04-26 | Colgate-Palmolive Company | Gelatin encapsulated oral care composition containing hydrophilic active, hydrophobic structuring agent and oil carrier |
| WO2012144943A1 (fr) * | 2011-04-18 | 2012-10-26 | Lipidor Ab | Véhicule liquide pour administration orale d'un agent pharmacologiquement actif |
| MX393195B (es) * | 2012-06-18 | 2025-03-24 | Therapeuticsmd Inc | Capsula de estradiol soluble para insercion por via vaginal |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| GB201304662D0 (en) | 2013-03-14 | 2013-05-01 | Sigmoid Pharma Ltd | Compositions |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| EA036036B1 (ru) | 2014-11-07 | 2020-09-16 | Сигмойд Фарма Лимитед | Композиции, содержащие циклоспорин |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE567598A (fr) * | ||||
| GB817241A (en) * | 1957-08-21 | 1959-07-29 | Vismara Francesco Spa | Oily solutions for parenteral administration containing adreno-cortical hormones |
| FR5530M (fr) * | 1965-02-18 | 1967-12-18 | ||
| DE2027325A1 (de) * | 1969-06-03 | 1970-12-17 | Sumitomo Chemical Company Ltd., Osaka (Japan) | Pharmazeutische Zusammensetzung und Verfahren zu ihrer Herstellung |
| US3708583A (en) * | 1970-04-03 | 1973-01-02 | Vitamin Premixers Of Omaha Inc | Stabilized vitamin a additive |
| FR2266512A1 (fr) * | 1974-04-04 | 1975-10-31 | Crinos Industria Farmaco | |
| US3920819A (en) * | 1974-12-02 | 1975-11-18 | Lilly Co Eli | Nonaqueous vehicle for oral pharmaceutical suspensions |
| NL7507745A (nl) * | 1974-07-04 | 1976-01-06 | Sandoz Ag | Werkwijze voor het bereiden van een galenisch ge- neesmiddel en de onder toepassing van deze werk- wijze verkregen gevormde geneesmiddelen. |
-
1977
- 1977-11-25 IT IT5195677A patent/IT1090703B/it active
- 1977-12-01 DE DE19772753526 patent/DE2753526A1/de active Pending
- 1977-12-01 AU AU31116/77A patent/AU3111677A/en active Pending
- 1977-12-02 JP JP14492177A patent/JPS5372814A/ja active Pending
- 1977-12-02 FR FR7736418A patent/FR2372635A1/fr not_active Withdrawn
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE567598A (fr) * | ||||
| GB817241A (en) * | 1957-08-21 | 1959-07-29 | Vismara Francesco Spa | Oily solutions for parenteral administration containing adreno-cortical hormones |
| FR5530M (fr) * | 1965-02-18 | 1967-12-18 | ||
| DE2027325A1 (de) * | 1969-06-03 | 1970-12-17 | Sumitomo Chemical Company Ltd., Osaka (Japan) | Pharmazeutische Zusammensetzung und Verfahren zu ihrer Herstellung |
| US3708583A (en) * | 1970-04-03 | 1973-01-02 | Vitamin Premixers Of Omaha Inc | Stabilized vitamin a additive |
| FR2266512A1 (fr) * | 1974-04-04 | 1975-10-31 | Crinos Industria Farmaco | |
| NL7507745A (nl) * | 1974-07-04 | 1976-01-06 | Sandoz Ag | Werkwijze voor het bereiden van een galenisch ge- neesmiddel en de onder toepassing van deze werk- wijze verkregen gevormde geneesmiddelen. |
| US3920819A (en) * | 1974-12-02 | 1975-11-18 | Lilly Co Eli | Nonaqueous vehicle for oral pharmaceutical suspensions |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2491333A1 (fr) * | 1980-10-06 | 1982-04-09 | Glaxo Group Ltd | Compositions pharmaceutiques administrables par voie topique et contenant des steroides anti-inflammatoires |
| FR2500302A1 (fr) * | 1981-02-25 | 1982-08-27 | Negma Laboratoires | Nouvelles compositions pharmaceutiques d'indometacine |
| EP0130514A3 (fr) * | 1983-07-05 | 1986-08-13 | Troponwerke GmbH & Co. KG | Compositions antiphlogistiques à effet dépôt |
| FR2549371A1 (fr) * | 1983-07-20 | 1985-01-25 | Sanofi Sa | Nouvelle composition pharmaceutique contenant de l'acide valproique ou un de ses sels |
| EP0343575A1 (fr) * | 1988-05-24 | 1989-11-29 | Günter Stephan | Capsule de gélatine molle |
| EP0517412A1 (fr) * | 1991-06-03 | 1992-12-09 | MERCK SHARP & DOHME LTD. | Formulations pharmaceutiques d'une benzodiazepine |
| WO1992021348A1 (fr) * | 1991-06-03 | 1992-12-10 | Merck Sharp & Dohme Limited | Compositions pharmaceutiques contenant une benzodiazepine |
| WO1994007472A1 (fr) * | 1992-10-02 | 1994-04-14 | Pfizer Inc. | Compositions pharmaceutiques contenant des tensioactifs non ioniques |
| WO1995012384A1 (fr) * | 1993-11-02 | 1995-05-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Formulation auto-emulsionnable formant une huile dans eau |
| US6096338A (en) * | 1994-03-16 | 2000-08-01 | R. P. Scherer Corporation | Delivery systems for hydrophobic drugs |
| WO1995024893A1 (fr) * | 1994-03-16 | 1995-09-21 | R.P. Scherer Limited | Systemes d'administration s'appliquant a des medicaments hydrophobes |
| EP1205180A3 (fr) * | 1994-03-16 | 2002-11-27 | R.P. Scherer Technologies, Inc. | Système d'administration d'actifs hydrophobes |
| WO1996019195A1 (fr) * | 1994-12-22 | 1996-06-27 | Laboratoire Innothera | Forme galenique unitaire destinee a la voie vaginale utilisable comme contraceptif local et/ou pour combattre les maladies sexuellement transmissibles et/ou les vih |
| LT4304B (lt) | 1994-12-22 | 1998-03-25 | Laboratoire Innothera | Dozuota galeninė kompozicija vaginaliniam naudojimui kaip vietinis kontraceptikas ir/arba prieš lytiniu keliu plintančias ligas ir/arba živ |
| RU2155582C2 (ru) * | 1994-12-22 | 2000-09-10 | Лаборатуар Иннотера | Дозированная галенова композиция для вагинального применения в качестве местного контрацептивного средства и/или для борьбы с заболеваниями, передающимися половым путем, и/или вич |
| FR2728464A1 (fr) * | 1994-12-22 | 1996-06-28 | Innothera Lab Sa | Forme galenique unitaire, son procede d'obtention et ses utilisations |
| US6664296B1 (en) | 1994-12-22 | 2003-12-16 | Laboratoire Innothera Societe Anonyme | Unit galenical formulation for vaginal use as a local contraceptive and/or to combat sexually-transmitted diseases and/or HIV |
| WO1999056727A3 (fr) * | 1998-05-07 | 2000-03-02 | Elan Corp Plc | Systemes d'apport de medicament de preconcentre de microemulsion et d'emulsion depourvues de solvant/cosolvant |
| EP1420767A4 (fr) * | 2001-08-27 | 2004-11-24 | Won Jin Biopharma Co Ltd | Compositions contenant de l'itraconazole et leurs procedes de preparation |
| WO2020157675A1 (fr) * | 2019-01-31 | 2020-08-06 | Gdański Uniwersytet Medyczny Z Siedzibą W Gdańsku | Composition pharmaceutique auto-émulsifiante sous forme liquide, contenant comme substance active une substance médicamenteuse instable dans un environnement aqueux |
Also Published As
| Publication number | Publication date |
|---|---|
| AU3111677A (en) | 1979-06-07 |
| JPS5372814A (en) | 1978-06-28 |
| IT1090703B (it) | 1985-06-26 |
| DE2753526A1 (de) | 1978-06-08 |
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