FR2407204A1 - Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments - Google Patents

Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments

Info

Publication number
FR2407204A1
FR2407204A1 FR7829752A FR7829752A FR2407204A1 FR 2407204 A1 FR2407204 A1 FR 2407204A1 FR 7829752 A FR7829752 A FR 7829752A FR 7829752 A FR7829752 A FR 7829752A FR 2407204 A1 FR2407204 A1 FR 2407204A1
Authority
FR
France
Prior art keywords
preparation
amino acid
cyclic amino
group
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7829752A
Other languages
English (en)
Inventor
Erik Wiskott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2407204A1 publication Critical patent/FR2407204A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

L'INVENTION CONCERNE DE NOUVEAUX AMIDES D'AMINO-ACIDES CYCLIQUES ET LEUR PREPARATION. LES COMPOSES DE L'INVENTION REPONDENT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE UN ATOME D'HYDROGENE, UN GROUPE CYCLOALKYLE, UN GROUPE ALKYLE SUBSTITUE, UN GROUPE PHENYLE OU PHENYL-ALKYLE SUBSTITUES OU UN RESTE HETEROCYCLIQUE, R ET R SIGNIFIENT CHACUN UN ATOME D'HYDROGENE OU UN GROUPE ALKYLE, A REPRESENTE UN GROUPE METHYLENE OU TRIMETHYLENE OU UN GROUPE ETHYLENE EVENTUELLEMENT SUBSTITUE ET N SIGNIFIE 0, 1 OU 2. CES COMPOSES PEUVENT ETRE UTILISES EN THERAPEUTIQUE A TITRE DE SUBSTANCES ACTIVES DE MEDICAMENTS.
FR7829752A 1977-10-28 1978-10-19 Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments Withdrawn FR2407204A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1315377 1977-10-28

Publications (1)

Publication Number Publication Date
FR2407204A1 true FR2407204A1 (fr) 1979-05-25

Family

ID=4389793

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7829752A Withdrawn FR2407204A1 (fr) 1977-10-28 1978-10-19 Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments

Country Status (16)

Country Link
US (1) US4261895A (fr)
JP (1) JPS5481266A (fr)
AU (1) AU4113878A (fr)
BE (1) BE871574A (fr)
DE (1) DE2845499A1 (fr)
DK (1) DK467378A (fr)
ES (1) ES474562A1 (fr)
FI (1) FI783189A7 (fr)
FR (1) FR2407204A1 (fr)
GB (1) GB2006781A (fr)
IL (1) IL55801A0 (fr)
IT (1) IT7851510A0 (fr)
NL (1) NL7810595A (fr)
PT (1) PT68707A (fr)
SE (1) SE7810893L (fr)
ZA (1) ZA786081B (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2438036A1 (fr) * 1978-10-05 1980-04-30 Yoshitomi Pharmaceutical Derives d'acides iminocarboxyliques cycliques et medicament contenant ces substances
FR2440365A1 (fr) * 1978-10-31 1980-05-30 Santen Pharmaceutical Co Ltd Nouveaux derives d'acides mercapto-azolidine-carboxyliques utiles comme hypertenseurs
FR2444669A1 (fr) * 1978-12-22 1980-07-18 Squibb & Sons Inc Acetals et thioacetals de mercap
FR2462428A1 (fr) * 1979-07-30 1981-02-13 Squibb & Sons Inc Derives d'acide dithioacyldihydropyrazole carboxylique, derives de dithioacylproline, et composes apparentes, a action antihypertensive
FR2467845A1 (fr) * 1979-10-22 1981-04-30 Squibb & Sons Inc Nouveaux derives mercapto-acyles de prolines 4,4-disubstituees et de dehydroprolines 4-substituees, utiles notamment comme medicaments hypotenseurs, compositions therapeutiques et formes pharmaceutiques les contenant, et intermediaires utiles pour leur synthese
EP0031104A1 (fr) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Composés de thiazolidine, procédés pour leur préparation et compositions pharmaceutiques les contenant
EP0060668A1 (fr) * 1981-03-12 1982-09-22 Beecham Group Plc Dérivés N-carboxyalcoyldipeptidiques et leurs compositions pharmaceutiques
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4745124A (en) * 1978-09-11 1988-05-17 University Of Miami Orally effective anti-hypertensive agents
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4565819A (en) * 1979-12-07 1986-01-21 Adir Substituted imino diacids, their preparation and pharmaceutical compositions which contain them
US4350704A (en) 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4344949A (en) 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
JPH06740B2 (ja) * 1984-08-16 1994-01-05 三菱レイヨン株式会社 光学活性カルボン酸アミドの製造法
IT1226796B (it) * 1988-07-15 1991-02-19 Simes Composizione farmaceutica utile per il trattamento di malattie cardiovascolari.
US5166361A (en) * 1988-09-13 1992-11-24 Sepracor, Inc. Methods for preparing captopril and its analogues
IL91581A (en) * 1988-09-13 1993-07-08 Sepracor Inc Methods for preparing optically active captopril and its analogues
IT1241415B (it) * 1990-03-05 1994-01-14 Yason Srl Derivato dell'acido s-(2-tenoil)-tiolattico ad attivita' farmacologica
US20020042377A1 (en) * 1995-06-07 2002-04-11 Steiner Joseph P. Rotamase enzyme activity inhibitors
US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2383171A1 (fr) * 1977-03-11 1978-10-06 Squibb & Sons Inc Derives de thiopropanoylaminoacides utiles comme hypotenseurs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
US4217458A (en) * 1978-12-08 1980-08-12 E. R. Squibb & Sons, Inc. Acylmercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2383171A1 (fr) * 1977-03-11 1978-10-06 Squibb & Sons Inc Derives de thiopropanoylaminoacides utiles comme hypotenseurs

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745124A (en) * 1978-09-11 1988-05-17 University Of Miami Orally effective anti-hypertensive agents
FR2438036A1 (fr) * 1978-10-05 1980-04-30 Yoshitomi Pharmaceutical Derives d'acides iminocarboxyliques cycliques et medicament contenant ces substances
FR2440365A1 (fr) * 1978-10-31 1980-05-30 Santen Pharmaceutical Co Ltd Nouveaux derives d'acides mercapto-azolidine-carboxyliques utiles comme hypertenseurs
FR2444669A1 (fr) * 1978-12-22 1980-07-18 Squibb & Sons Inc Acetals et thioacetals de mercap
FR2462428A1 (fr) * 1979-07-30 1981-02-13 Squibb & Sons Inc Derives d'acide dithioacyldihydropyrazole carboxylique, derives de dithioacylproline, et composes apparentes, a action antihypertensive
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
FR2467845A1 (fr) * 1979-10-22 1981-04-30 Squibb & Sons Inc Nouveaux derives mercapto-acyles de prolines 4,4-disubstituees et de dehydroprolines 4-substituees, utiles notamment comme medicaments hypotenseurs, compositions therapeutiques et formes pharmaceutiques les contenant, et intermediaires utiles pour leur synthese
EP0031104A1 (fr) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Composés de thiazolidine, procédés pour leur préparation et compositions pharmaceutiques les contenant
EP0060668A1 (fr) * 1981-03-12 1982-09-22 Beecham Group Plc Dérivés N-carboxyalcoyldipeptidiques et leurs compositions pharmaceutiques
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors

Also Published As

Publication number Publication date
NL7810595A (nl) 1979-05-02
BE871574A (fr) 1979-04-26
DE2845499A1 (de) 1979-05-03
US4261895A (en) 1981-04-14
AU4113878A (en) 1980-05-01
IT7851510A0 (it) 1978-10-16
ZA786081B (en) 1980-06-25
GB2006781A (en) 1979-05-10
ES474562A1 (es) 1979-10-16
PT68707A (fr) 1978-11-01
JPS5481266A (en) 1979-06-28
FI783189A7 (fi) 1979-04-29
DK467378A (da) 1979-04-29
IL55801A0 (en) 1978-12-17
SE7810893L (sv) 1979-04-29

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Legal Events

Date Code Title Description
RE Withdrawal of published application