FR2421904A2 - Nouvelles oximes derivees de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur ap - Google Patents
Nouvelles oximes derivees de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur apInfo
- Publication number
- FR2421904A2 FR2421904A2 FR7726059A FR7726059A FR2421904A2 FR 2421904 A2 FR2421904 A2 FR 2421904A2 FR 7726059 A FR7726059 A FR 7726059A FR 7726059 A FR7726059 A FR 7726059A FR 2421904 A2 FR2421904 A2 FR 2421904A2
- Authority
- FR
- France
- Prior art keywords
- thiazolyl
- reaction
- enzymatic
- antibiotics
- hydrolysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 title abstract 2
- 230000002255 enzymatic effect Effects 0.000 title abstract 2
- 238000006640 acetylation reaction Methods 0.000 title 1
- 239000012948 isocyanate Substances 0.000 title 1
- 150000002513 isocyanates Chemical class 0.000 title 1
- -1 alkaline earth Substances 0.000 abstract 2
- 125000002668 chloroacetyl group Chemical group ClCC(=O)* 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 241000295644 Staphylococcaceae Species 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 230000006196 deacetylation Effects 0.000 abstract 1
- 238000003381 deacetylation reaction Methods 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Produit suivant répondant à la formule du brevet principal : le sel de sodium de l'acide 3-carbamoyloxyméthyl 7-/2-(2-amino 4-thiazolyl) 2-méthoxyimino acétamido/céph-3** e 4-carboxylique, isomère syn, et application à titre de medicament de ce produit. Procédés selon le brevet principal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7726059A FR2421904A2 (fr) | 1977-08-26 | 1977-08-26 | Nouvelles oximes derivees de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur ap |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7726059A FR2421904A2 (fr) | 1977-08-26 | 1977-08-26 | Nouvelles oximes derivees de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur ap |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2421904A2 true FR2421904A2 (fr) | 1979-11-02 |
| FR2421904B2 FR2421904B2 (fr) | 1983-04-29 |
Family
ID=9194805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7726059A Granted FR2421904A2 (fr) | 1977-08-26 | 1977-08-26 | Nouvelles oximes derivees de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur ap |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2421904A2 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0155103A3 (en) * | 1984-02-24 | 1986-07-23 | Kureha Kagaku Kogyo Kabushiki Kaisha | Cephalosporin derivatives |
-
1977
- 1977-08-26 FR FR7726059A patent/FR2421904A2/fr active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0155103A3 (en) * | 1984-02-24 | 1986-07-23 | Kureha Kagaku Kogyo Kabushiki Kaisha | Cephalosporin derivatives |
| US4734409A (en) * | 1984-02-24 | 1988-03-29 | Kureha Kagaku Kogyo Kabushiki Kaisha | Cephalosporin derivative, process for producing the same and pharmaceutical composition containing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2421904B2 (fr) | 1983-04-29 |
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